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Type 1diabetes in parents and risk of attention deficit/hyperactivity disorder in offspring : A population-based study in Sweden

Ji, Jianguang LU ; Chen, Tianhui LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2018) In Diabetes Care 41(4). p.770-774
Abstract

OBJECTIVE To explore whether a family history of type 1 diabetes (T1D) is associated with an increased incidence of attention deficit/hyperactivity disorder (ADHD) in offspring. RESEARCH DESIGN AND METHODS Individuals with T1D were identified from the nationwide Swedish National Hospital Discharge Register and Swedish Outpatient Register in Sweden and were linked to the SwedishMulti-Generation Register to identify their offspring. Cox regression was used to calculate the hazard ratio (HR) of ADHD in offspring of patients with T1D compared with the general population. RESULTS A total of 15,615 individuals were born after their parents were diagnosed with T1D. After a set of confounDing factors was controlled for, offspring of T1D... (More)

OBJECTIVE To explore whether a family history of type 1 diabetes (T1D) is associated with an increased incidence of attention deficit/hyperactivity disorder (ADHD) in offspring. RESEARCH DESIGN AND METHODS Individuals with T1D were identified from the nationwide Swedish National Hospital Discharge Register and Swedish Outpatient Register in Sweden and were linked to the SwedishMulti-Generation Register to identify their offspring. Cox regression was used to calculate the hazard ratio (HR) of ADHD in offspring of patients with T1D compared with the general population. RESULTS A total of 15,615 individuals were born after their parents were diagnosed with T1D. After a set of confounDing factors was controlled for, offspring of T1D patients had a significantly increased risk of ADHD with an HR of 1.29 (95% CI 1.15-1.42). Maternal T1D was associated with an enhanced risk of ADHD (HR 1.35 [95% CI 1.18-1.55]) comparedwith paternal T1D (HR 1.20 [95% CI 1.03-1.41]), but the differencewas not statistically significant. CONCLUSIONS In this retrospective cohort study, we found that a parental history of T1D was associated with a 29% increased risk of being diagnosed with ADHD. However, the underlying mechanisms need to be explored in future studies.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
41
issue
4
pages
5 pages
publisher
American Diabetes Association
external identifiers
  • scopus:85044517882
  • pmid:29374069
ISSN
0149-5992
DOI
10.2337/dc17-0592
language
English
LU publication?
yes
id
3c0f9ab1-b2a7-435c-9c8e-c80d0c50d4ee
date added to LUP
2018-04-10 12:33:30
date last changed
2020-01-16 03:19:04
@article{3c0f9ab1-b2a7-435c-9c8e-c80d0c50d4ee,
  abstract     = {<p>OBJECTIVE To explore whether a family history of type 1 diabetes (T1D) is associated with an increased incidence of attention deficit/hyperactivity disorder (ADHD) in offspring. RESEARCH DESIGN AND METHODS Individuals with T1D were identified from the nationwide Swedish National Hospital Discharge Register and Swedish Outpatient Register in Sweden and were linked to the SwedishMulti-Generation Register to identify their offspring. Cox regression was used to calculate the hazard ratio (HR) of ADHD in offspring of patients with T1D compared with the general population. RESULTS A total of 15,615 individuals were born after their parents were diagnosed with T1D. After a set of confounDing factors was controlled for, offspring of T1D patients had a significantly increased risk of ADHD with an HR of 1.29 (95% CI 1.15-1.42). Maternal T1D was associated with an enhanced risk of ADHD (HR 1.35 [95% CI 1.18-1.55]) comparedwith paternal T1D (HR 1.20 [95% CI 1.03-1.41]), but the differencewas not statistically significant. CONCLUSIONS In this retrospective cohort study, we found that a parental history of T1D was associated with a 29% increased risk of being diagnosed with ADHD. However, the underlying mechanisms need to be explored in future studies.</p>},
  author       = {Ji, Jianguang and Chen, Tianhui and Sundquist, Jan and Sundquist, Kristina},
  issn         = {0149-5992},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {770--774},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Type 1diabetes in parents and risk of attention deficit/hyperactivity disorder in offspring : A population-based study in Sweden},
  url          = {http://dx.doi.org/10.2337/dc17-0592},
  doi          = {10.2337/dc17-0592},
  volume       = {41},
  year         = {2018},
}