Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions : Of Use in Targeted Rehabilitative Approaches?
(2022) In Journal of Clinical Medicine 11(2).- Abstract
Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of postinjury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC were included ≥6 months post-injury, and 10 (age-matched) healthy controls (HC) were analyzed. The Repeatable Battery for the Assessment of Neuropsychological Status was performed at the time of DTI. Major white matter pathways were tracked using q-space diffeomorphic reconstruction and analyzed for global and regional changes with a controlled... (More)
Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of postinjury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC were included ≥6 months post-injury, and 10 (age-matched) healthy controls (HC) were analyzed. The Repeatable Battery for the Assessment of Neuropsychological Status was performed at the time of DTI. Major white matter pathways were tracked using q-space diffeomorphic reconstruction and analyzed for global and regional changes with a controlled false discovery rate. TBI patients displayed multiple classic white matter injuries compared with HC (p < 0.01). At the regional white matter analysis, the left frontal aslant tract, anterior thalamic radiation, and the genu of the corpus callosum displayed focal changes in both groups compared with HC but with different trends. Both TBI and rSRC displayed worse memory performance compared with HC (p < 0.05). While global analysis of DTI-based parameters did not reveal common abnormalities in TBI and rSRC, abnormalities to the fronto-thalamic network were observed in both groups using regional analysis of the white matter pathways. These results may be valuable to tailor individualized rehabilitative approaches for post-injury cognitive impairment in both TBI and rSRC patients.
(Less)
- author
- Latini, Francesco
; Fahlström, Markus
; Vedung, Fredrik
; Stensson, Staffan
; Larsson, Elna Marie
LU
; Lubberink, Mark
; Tegner, Yelverton
; Haller, Sven
; Johansson, Jakob
; Wall, Anders
; Antoni, Gunnar
and Marklund, Niklas
LU
(Less) - organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diffusion tensor imaging, Memory impairment, Rehabilitative approaches, Sport related concussion, Traumatic brain injury, White matter lesions
- in
- Journal of Clinical Medicine
- volume
- 11
- issue
- 2
- article number
- 358
- publisher
- MDPI AG
- external identifiers
-
- pmid:35054052
- scopus:85122680071
- ISSN
- 2077-0383
- DOI
- 10.3390/jcm11020358
- language
- English
- LU publication?
- yes
- id
- 3c4b2649-0922-45e6-89bd-9fc5f031758a
- date added to LUP
- 2022-03-01 08:48:41
- date last changed
- 2024-06-14 13:35:56
@article{3c4b2649-0922-45e6-89bd-9fc5f031758a,
abstract = {{<p>Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of postinjury regional white matter changes after TBI and rSRC. Six patients with moderate/severe TBI, and 12 athletes with rSRC were included ≥6 months post-injury, and 10 (age-matched) healthy controls (HC) were analyzed. The Repeatable Battery for the Assessment of Neuropsychological Status was performed at the time of DTI. Major white matter pathways were tracked using q-space diffeomorphic reconstruction and analyzed for global and regional changes with a controlled false discovery rate. TBI patients displayed multiple classic white matter injuries compared with HC (p < 0.01). At the regional white matter analysis, the left frontal aslant tract, anterior thalamic radiation, and the genu of the corpus callosum displayed focal changes in both groups compared with HC but with different trends. Both TBI and rSRC displayed worse memory performance compared with HC (p < 0.05). While global analysis of DTI-based parameters did not reveal common abnormalities in TBI and rSRC, abnormalities to the fronto-thalamic network were observed in both groups using regional analysis of the white matter pathways. These results may be valuable to tailor individualized rehabilitative approaches for post-injury cognitive impairment in both TBI and rSRC patients.</p>}},
author = {{Latini, Francesco and Fahlström, Markus and Vedung, Fredrik and Stensson, Staffan and Larsson, Elna Marie and Lubberink, Mark and Tegner, Yelverton and Haller, Sven and Johansson, Jakob and Wall, Anders and Antoni, Gunnar and Marklund, Niklas}},
issn = {{2077-0383}},
keywords = {{Diffusion tensor imaging; Memory impairment; Rehabilitative approaches; Sport related concussion; Traumatic brain injury; White matter lesions}},
language = {{eng}},
number = {{2}},
publisher = {{MDPI AG}},
series = {{Journal of Clinical Medicine}},
title = {{Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions : Of Use in Targeted Rehabilitative Approaches?}},
url = {{http://dx.doi.org/10.3390/jcm11020358}},
doi = {{10.3390/jcm11020358}},
volume = {{11}},
year = {{2022}},
}