Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus

Nakawesi, J LU ; This, S ; Hütter, J ; Boucard-Jourdin, M ; Barateau, V ; Muleta, K Getachew ; Gooday, L J ; Thomsen, K Fog ; López, A Garcias and Ulmert, I LU , et al. (2021) In Mucosal Immunology 9(2). p.53-67
Abstract

Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGFβ-activating integrin αvβ8 by cDC1. In contrast, αvβ8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are crucial in driving IgA during steady state but are dispensable for RV-specific IgA responses, we... (More)

Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGFβ-activating integrin αvβ8 by cDC1. In contrast, αvβ8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are crucial in driving IgA during steady state but are dispensable for RV-specific IgA responses, we propose that the capacity of DC subsets to induce intestinal IgA responses reflects the context, as opposed to an intrinsic property of individual DC subsets.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mucosal Immunology
volume
9
issue
2
pages
53 - 67
publisher
Nature Publishing Group
external identifiers
  • scopus:85081900595
  • pmid:32161355
ISSN
1933-0219
DOI
10.1038/s41385-020-0276-8
language
English
LU publication?
yes
id
3c582c0c-fd0f-4f2f-a0da-e38f62a7605c
date added to LUP
2020-05-18 21:30:47
date last changed
2024-06-26 15:24:40
@article{3c582c0c-fd0f-4f2f-a0da-e38f62a7605c,
  abstract     = {{<p>Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGFβ-activating integrin αvβ8 by cDC1. In contrast, αvβ8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are crucial in driving IgA during steady state but are dispensable for RV-specific IgA responses, we propose that the capacity of DC subsets to induce intestinal IgA responses reflects the context, as opposed to an intrinsic property of individual DC subsets.</p>}},
  author       = {{Nakawesi, J and This, S and Hütter, J and Boucard-Jourdin, M and Barateau, V and Muleta, K Getachew and Gooday, L J and Thomsen, K Fog and López, A Garcias and Ulmert, I and Poncet, D and Malissen, B and Greenberg, H and Thaunat, O and Defrance, T and Paidassi, H and Lahl, K}},
  issn         = {{1933-0219}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{53--67}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Mucosal Immunology}},
  title        = {{αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus}},
  url          = {{http://dx.doi.org/10.1038/s41385-020-0276-8}},
  doi          = {{10.1038/s41385-020-0276-8}},
  volume       = {{9}},
  year         = {{2021}},
}