Abnormal fetal aortic velocity waveform and minor neurological dysfunction at 7 years of age
(1996) In Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 8(3). p.9-152- Abstract
Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of the more severe form of minor neurological dysfunction, MND-2, was higher in the group with blood flow class (BFC) III (absent or reversed end-diastolic flow velocity (8/21) than in the group with BFC 0 (normal velocity waveform) (14/105). Logistic regression analysis revealed that abnormal blood flow class, both independently and in... (More)
Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of the more severe form of minor neurological dysfunction, MND-2, was higher in the group with blood flow class (BFC) III (absent or reversed end-diastolic flow velocity (8/21) than in the group with BFC 0 (normal velocity waveform) (14/105). Logistic regression analysis revealed that abnormal blood flow class, both independently and in combination with other factors, was the most significant predictor of MND-2. The association found between abnormal fetal aortic velocity waveforms and adverse outcome in terms of minor neurological dysfunction suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal neurological development.
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- author
- Ley, D LU ; Laurin, J ; Bjerre, I and Marsal, K LU
- organization
- publishing date
- 1996-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Analysis of Variance, Aorta, Thoracic/diagnostic imaging, Blood Flow Velocity, Child, Child Development, Female, Fetal Growth Retardation/complications, Fetal Heart/physiopathology, Hemodynamics/physiology, Humans, Infant, Newborn, Infant, Small for Gestational Age, Logistic Models, Longitudinal Studies, Nervous System Diseases/diagnosis, Predictive Value of Tests, Pregnancy, Prospective Studies, Risk Factors, Ultrasonography, Prenatal
- in
- Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
- volume
- 8
- issue
- 3
- pages
- 9 - 152
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:8915083
- scopus:0030228802
- ISSN
- 0960-7692
- DOI
- 10.1046/j.1469-0705.1996.08030152.x
- language
- English
- LU publication?
- yes
- id
- 3c85017b-8721-4dcc-b726-0b6eae688e77
- date added to LUP
- 2021-02-15 18:55:08
- date last changed
- 2024-02-17 16:58:14
@article{3c85017b-8721-4dcc-b726-0b6eae688e77, abstract = {{<p>Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of the more severe form of minor neurological dysfunction, MND-2, was higher in the group with blood flow class (BFC) III (absent or reversed end-diastolic flow velocity (8/21) than in the group with BFC 0 (normal velocity waveform) (14/105). Logistic regression analysis revealed that abnormal blood flow class, both independently and in combination with other factors, was the most significant predictor of MND-2. The association found between abnormal fetal aortic velocity waveforms and adverse outcome in terms of minor neurological dysfunction suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal neurological development.</p>}}, author = {{Ley, D and Laurin, J and Bjerre, I and Marsal, K}}, issn = {{0960-7692}}, keywords = {{Analysis of Variance; Aorta, Thoracic/diagnostic imaging; Blood Flow Velocity; Child; Child Development; Female; Fetal Growth Retardation/complications; Fetal Heart/physiopathology; Hemodynamics/physiology; Humans; Infant, Newborn; Infant, Small for Gestational Age; Logistic Models; Longitudinal Studies; Nervous System Diseases/diagnosis; Predictive Value of Tests; Pregnancy; Prospective Studies; Risk Factors; Ultrasonography, Prenatal}}, language = {{eng}}, number = {{3}}, pages = {{9--152}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology}}, title = {{Abnormal fetal aortic velocity waveform and minor neurological dysfunction at 7 years of age}}, url = {{http://dx.doi.org/10.1046/j.1469-0705.1996.08030152.x}}, doi = {{10.1046/j.1469-0705.1996.08030152.x}}, volume = {{8}}, year = {{1996}}, }