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Abnormal fetal aortic velocity waveform and minor neurological dysfunction at 7 years of age

Ley, D LU ; Laurin, J ; Bjerre, I and Marsal, K LU (1996) In Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 8(3). p.9-152
Abstract

Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of the more severe form of minor neurological dysfunction, MND-2, was higher in the group with blood flow class (BFC) III (absent or reversed end-diastolic flow velocity (8/21) than in the group with BFC 0 (normal velocity waveform) (14/105). Logistic regression analysis revealed that abnormal blood flow class, both independently and in... (More)

Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was > or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of the more severe form of minor neurological dysfunction, MND-2, was higher in the group with blood flow class (BFC) III (absent or reversed end-diastolic flow velocity (8/21) than in the group with BFC 0 (normal velocity waveform) (14/105). Logistic regression analysis revealed that abnormal blood flow class, both independently and in combination with other factors, was the most significant predictor of MND-2. The association found between abnormal fetal aortic velocity waveforms and adverse outcome in terms of minor neurological dysfunction suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal neurological development.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Analysis of Variance, Aorta, Thoracic/diagnostic imaging, Blood Flow Velocity, Child, Child Development, Female, Fetal Growth Retardation/complications, Fetal Heart/physiopathology, Hemodynamics/physiology, Humans, Infant, Newborn, Infant, Small for Gestational Age, Logistic Models, Longitudinal Studies, Nervous System Diseases/diagnosis, Predictive Value of Tests, Pregnancy, Prospective Studies, Risk Factors, Ultrasonography, Prenatal
in
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
volume
8
issue
3
pages
9 - 152
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:8915083
  • scopus:0030228802
ISSN
0960-7692
DOI
10.1046/j.1469-0705.1996.08030152.x
language
English
LU publication?
yes
id
3c85017b-8721-4dcc-b726-0b6eae688e77
date added to LUP
2021-02-15 18:55:08
date last changed
2024-02-17 16:58:14
@article{3c85017b-8721-4dcc-b726-0b6eae688e77,
  abstract     = {{<p>Measurements of fetal aortic blood flow velocity and fetal growth were performed in 178 pregnancies. In 87 cases, the estimated fetal weight was &gt; or = 2 SD below the gestational age-related mean of the population. Three fetuses died in utero. In 149 children (85%), a neurological examination was performed at 7 years of age with special emphasis on minor neurological dysfunction. The frequency of the more severe form of minor neurological dysfunction, MND-2, was higher in the group with blood flow class (BFC) III (absent or reversed end-diastolic flow velocity (8/21) than in the group with BFC 0 (normal velocity waveform) (14/105). Logistic regression analysis revealed that abnormal blood flow class, both independently and in combination with other factors, was the most significant predictor of MND-2. The association found between abnormal fetal aortic velocity waveforms and adverse outcome in terms of minor neurological dysfunction suggests that hemodynamic evaluation of the fetus has a predictive value regarding postnatal neurological development.</p>}},
  author       = {{Ley, D and Laurin, J and Bjerre, I and Marsal, K}},
  issn         = {{0960-7692}},
  keywords     = {{Analysis of Variance; Aorta, Thoracic/diagnostic imaging; Blood Flow Velocity; Child; Child Development; Female; Fetal Growth Retardation/complications; Fetal Heart/physiopathology; Hemodynamics/physiology; Humans; Infant, Newborn; Infant, Small for Gestational Age; Logistic Models; Longitudinal Studies; Nervous System Diseases/diagnosis; Predictive Value of Tests; Pregnancy; Prospective Studies; Risk Factors; Ultrasonography, Prenatal}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{9--152}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology}},
  title        = {{Abnormal fetal aortic velocity waveform and minor neurological dysfunction at 7 years of age}},
  url          = {{http://dx.doi.org/10.1046/j.1469-0705.1996.08030152.x}},
  doi          = {{10.1046/j.1469-0705.1996.08030152.x}},
  volume       = {{8}},
  year         = {{1996}},
}