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Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis

Julia, Eva; Montalban, Xavier; Al-zayat, Hanimad; Issazadeh, Shohreh LU ; Goertsches, Robert; Martin, Roland and Comabella, Manuel (2006) In Journal of Neuroimmunology 180(1-2). p.147-158
Abstract
Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
multiple sclerosis, T cells, apoptosis
in
Journal of Neuroimmunology
volume
180
issue
1-2
pages
147 - 158
publisher
Elsevier
external identifiers
  • wos:000242694500016
  • scopus:33750618350
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2006.07.001
language
English
LU publication?
yes
id
3ca6914e-4148-439a-a83d-17e17acc6a5d (old id 682454)
date added to LUP
2007-12-20 09:25:32
date last changed
2019-02-20 03:56:09
@article{3ca6914e-4148-439a-a83d-17e17acc6a5d,
  abstract     = {Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.},
  author       = {Julia, Eva and Montalban, Xavier and Al-zayat, Hanimad and Issazadeh, Shohreh and Goertsches, Robert and Martin, Roland and Comabella, Manuel},
  issn         = {1872-8421},
  keyword      = {multiple sclerosis,T cells,apoptosis},
  language     = {eng},
  number       = {1-2},
  pages        = {147--158},
  publisher    = {Elsevier},
  series       = {Journal of Neuroimmunology},
  title        = {Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis},
  url          = {http://dx.doi.org/10.1016/j.jneuroim.2006.07.001},
  volume       = {180},
  year         = {2006},
}