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Linking bronchopulmonary dysplasia to adult chronic lung diseases : role of WNT signaling

Ota, Chiharu; Baarsma, Hoeke A.; Wagner, Darcy E LU ; Hilgendorff, Anne and Königshoff, Melanie (2016) In Molecular and cellular pediatrics 3. p.1-13
Abstract

Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung... (More)

Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.

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author
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publication status
published
subject
keywords
Review, Journal Article
in
Molecular and cellular pediatrics
volume
3
pages
1 - 13
ISSN
2194-7791
DOI
10.1186/s40348-016-0062-6
language
English
LU publication?
no
id
3ce680e2-b2c0-473a-bf5c-76033e8336bb
date added to LUP
2017-08-15 15:19:18
date last changed
2017-08-15 16:00:19
@article{3ce680e2-b2c0-473a-bf5c-76033e8336bb,
  abstract     = {<p>Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in infants caused by pre- and/or postnatal lung injury. BPD is characterized by arrested alveolarization and vascularization due to extracellular matrix remodeling, inflammation, and impaired growth factor signaling. WNT signaling is a critical pathway for normal lung development, and its altered signaling has been shown to be involved in the onset and progression of incurable chronic lung diseases in adulthood, such as chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibrosis (IPF). In this review, we summarize the impact of WNT signaling on different stages of lung development and its potential contribution to developmental lung diseases, especially BPD, and chronic lung diseases in adulthood.</p>},
  articleno    = {34},
  author       = {Ota, Chiharu and Baarsma, Hoeke A. and Wagner, Darcy E and Hilgendorff, Anne and Königshoff, Melanie},
  issn         = {2194-7791},
  keyword      = {Review,Journal Article},
  language     = {eng},
  pages        = {1--13},
  series       = {Molecular and cellular pediatrics},
  title        = {Linking bronchopulmonary dysplasia to adult chronic lung diseases : role of WNT signaling},
  url          = {http://dx.doi.org/10.1186/s40348-016-0062-6},
  volume       = {3},
  year         = {2016},
}