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Identification of Immune Responses Against Aldehyde-Modified Peptide Sequences in ApoB Associated With Cardiovascular Disease.

Nordin Fredrikson, Gunilla LU ; Hedblad, Bo LU ; Berglund, Göran LU ; Alm, Ragnar LU ; Ares, Mikko LU ; Cercek, Bojan ; Chyu, Kuang-Yuh ; Shah, Prediman K. and Nilsson, Jan LU (2003) In Arteriosclerosis, Thrombosis and Vascular Biology 23(5). p.872-878
Abstract
Objective— Atherosclerosis is associated with an immune response against oxidized LDL, which modulates the progression of the disease process.



Methods and Results— Using a library of polypeptides covering the complete sequence of apoB-100, the only major protein of LDL, we have identified over 100 different human antibodies reacting against aldehyde-modified apoB-100 sequences. IgM antibody titer levels decreased with age and were associated with the intima-media thickness of the carotid artery in subjects younger than 60 years. There were also inverse associations between IgM levels and oxidized LDL in plasma. In prospective clinical studies, antibody levels against several aldehyde-modified apoB-100 sites were... (More)
Objective— Atherosclerosis is associated with an immune response against oxidized LDL, which modulates the progression of the disease process.



Methods and Results— Using a library of polypeptides covering the complete sequence of apoB-100, the only major protein of LDL, we have identified over 100 different human antibodies reacting against aldehyde-modified apoB-100 sequences. IgM antibody titer levels decreased with age and were associated with the intima-media thickness of the carotid artery in subjects younger than 60 years. There were also inverse associations between IgM levels and oxidized LDL in plasma. In prospective clinical studies, antibody levels against several aldehyde-modified apoB-100 sites were associated with cardiovascular disease in this age group. Whether this immune response is adaptive (protective) or maladaptive (causal) in atherosclerosis requires further investigation.



Conclusions— We have characterized a large number of epitopes within the apoB-100 component of oxidized LDL that provoke an immune response in humans. These findings will make it possible to study the role of immune responses against specific sites in oxidized LDL and to determine whether these immune responses influence the risk for future cardiac events. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
responses, cardiovascular diseases, apolipoproteins, atherosclerosis, peptide sequences, immune
in
Arteriosclerosis, Thrombosis and Vascular Biology
volume
23
issue
5
pages
872 - 878
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000182742500027
  • pmid:12649091
  • scopus:0038222531
ISSN
1524-4636
DOI
10.1161/01.ATV.0000067935.02679.B0
language
English
LU publication?
yes
id
3cf64dd6-64fd-4b5e-b6bc-1a2366c60be1 (old id 112663)
alternative location
http://dx.doi.org/10.1161/01.ATV.0000067935.02679.B0
date added to LUP
2016-04-01 12:32:12
date last changed
2022-02-11 08:20:35
@article{3cf64dd6-64fd-4b5e-b6bc-1a2366c60be1,
  abstract     = {{Objective— Atherosclerosis is associated with an immune response against oxidized LDL, which modulates the progression of the disease process.<br/><br>
<br/><br>
Methods and Results— Using a library of polypeptides covering the complete sequence of apoB-100, the only major protein of LDL, we have identified over 100 different human antibodies reacting against aldehyde-modified apoB-100 sequences. IgM antibody titer levels decreased with age and were associated with the intima-media thickness of the carotid artery in subjects younger than 60 years. There were also inverse associations between IgM levels and oxidized LDL in plasma. In prospective clinical studies, antibody levels against several aldehyde-modified apoB-100 sites were associated with cardiovascular disease in this age group. Whether this immune response is adaptive (protective) or maladaptive (causal) in atherosclerosis requires further investigation.<br/><br>
<br/><br>
Conclusions— We have characterized a large number of epitopes within the apoB-100 component of oxidized LDL that provoke an immune response in humans. These findings will make it possible to study the role of immune responses against specific sites in oxidized LDL and to determine whether these immune responses influence the risk for future cardiac events.}},
  author       = {{Nordin Fredrikson, Gunilla and Hedblad, Bo and Berglund, Göran and Alm, Ragnar and Ares, Mikko and Cercek, Bojan and Chyu, Kuang-Yuh and Shah, Prediman K. and Nilsson, Jan}},
  issn         = {{1524-4636}},
  keywords     = {{responses; cardiovascular diseases; apolipoproteins; atherosclerosis; peptide sequences; immune}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{872--878}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Arteriosclerosis, Thrombosis and Vascular Biology}},
  title        = {{Identification of Immune Responses Against Aldehyde-Modified Peptide Sequences in ApoB Associated With Cardiovascular Disease.}},
  url          = {{http://dx.doi.org/10.1161/01.ATV.0000067935.02679.B0}},
  doi          = {{10.1161/01.ATV.0000067935.02679.B0}},
  volume       = {{23}},
  year         = {{2003}},
}