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Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes

Maldonado, Mario ; Hampe, Christiane S ; Gaur, Lakshmi K ; D'Amico, Susana ; Iyer, Dinakar ; Hammerle, Lisa P ; Bolgiano, Douglas ; Rodriguez, Lucille ; Rajan, Arun and Lernmark, Åke LU , et al. (2003) In Journal of Clinical Endocrinology and Metabolism 88(11). p.5090-5098
Abstract
Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell functional defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated for beta-cell autoimmunity and human leukocyte antigen (HLA) class II alleles, with longitudinal measurements of beta-cell function and biochemical and clinical parameters. They were classified into four A beta groups, based on the presence of glutamic acid decarboxylase (GAD)65, GAD67, or IA-2 autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ or beta-). The group distribution was: 18 A+beta-, 23 A-beta-, 11 A+beta+, and 51 A-beta+. Collectively, the two beta- groups differed from the two beta+ groups in earlier onset and longer duration of... (More)
Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell functional defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated for beta-cell autoimmunity and human leukocyte antigen (HLA) class II alleles, with longitudinal measurements of beta-cell function and biochemical and clinical parameters. They were classified into four A beta groups, based on the presence of glutamic acid decarboxylase (GAD)65, GAD67, or IA-2 autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ or beta-). The group distribution was: 18 A+beta-, 23 A-beta-, 11 A+beta+, and 51 A-beta+. Collectively, the two beta- groups differed from the two beta+ groups in earlier onset and longer duration of diabetes, lower body mass index, less glycemic improvement, and persistent insulin requirement. HLA class II genotyping showed that the A-beta- group differed from the A+beta- group in having lower frequencies of two alleles strongly associated with (Less)
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publication status
published
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in
Journal of Clinical Endocrinology and Metabolism
volume
88
issue
11
pages
5090 - 5098
publisher
The Endocrine Society
external identifiers
  • scopus:10744227156
  • pmid:14602731
ISSN
1945-7197
DOI
10.1210/jc.2003-030180
language
English
LU publication?
yes
id
3d5a9e09-a8f7-4548-afe4-6752b7e33e8b (old id 1127391)
date added to LUP
2016-04-01 17:01:11
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2019-12-04 05:31:10
@article{3d5a9e09-a8f7-4548-afe4-6752b7e33e8b,
  abstract     = {Ketosis-prone diabetes is heterogeneous. Its causes could include novel beta-cell functional defects. To characterize such defects, 103 patients with diabetic ketoacidosis were evaluated for beta-cell autoimmunity and human leukocyte antigen (HLA) class II alleles, with longitudinal measurements of beta-cell function and biochemical and clinical parameters. They were classified into four A beta groups, based on the presence of glutamic acid decarboxylase (GAD)65, GAD67, or IA-2 autoantibodies (A+ or A-) and beta-cell functional reserve (beta+ or beta-). The group distribution was: 18 A+beta-, 23 A-beta-, 11 A+beta+, and 51 A-beta+. Collectively, the two beta- groups differed from the two beta+ groups in earlier onset and longer duration of diabetes, lower body mass index, less glycemic improvement, and persistent insulin requirement. HLA class II genotyping showed that the A-beta- group differed from the A+beta- group in having lower frequencies of two alleles strongly associated with},
  author       = {Maldonado, Mario and Hampe, Christiane S and Gaur, Lakshmi K and D'Amico, Susana and Iyer, Dinakar and Hammerle, Lisa P and Bolgiano, Douglas and Rodriguez, Lucille and Rajan, Arun and Lernmark, Åke and Balasubramanyam, Ashok},
  issn         = {1945-7197},
  language     = {eng},
  number       = {11},
  pages        = {5090--5098},
  publisher    = {The Endocrine Society},
  series       = {Journal of Clinical Endocrinology and Metabolism},
  title        = {Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes},
  url          = {http://dx.doi.org/10.1210/jc.2003-030180},
  doi          = {10.1210/jc.2003-030180},
  volume       = {88},
  year         = {2003},
}