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RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5

Api, A M; Belsito, D; Botelho, D.; Browne, D.; Bruze, M. LU ; Burton, G. A.; Buschmann, J.; Calow, P.; Dagli, M L and Date, M., et al. (2017) In Food and Chemical Toxicology
Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental... (More)

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

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@article{3d7fd6de-b73c-465e-a75b-d03e4060d8a1,
  abstract     = {<p>The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE &gt; 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.</p>},
  author       = {Api, A M and Belsito, D and Botelho, D. and Browne, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Calow, P. and Dagli, M L and Date, M. and Dekant, W. and Deodhar, C. and Fryer, A. D. and Joshi, K. D. and La Cava, S and Lapczynski, A and Liebler, D C and O'Brien, Kevin D. and Parakhia, R. and Patel, A. and Penning, T. M. and Ritacco, G and Romine, J. and Salvito, D and Schultz, T W and Sipes, I G and Thakkar, Y. and Tsang, Shui Lung and Wahler, J.},
  issn         = {0278-6915},
  keyword      = {Developmental and reproductive toxicity,Environmental safety,Genotoxicity,Local respiratory toxicity,Phototoxicity/photoallergenicity,Repeated dose,Skin sensitization},
  language     = {eng},
  month        = {05},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5},
  url          = {http://dx.doi.org/10.1016/j.fct.2017.05.066},
  year         = {2017},
}