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RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5

Api, A M ; Belsito, D ; Botelho, D. ; Browne, D. ; Bruze, M. LU ; Burton, G. A. ; Buschmann, J. ; Calow, P. ; Dagli, M L and Date, M. , et al. (2017) In Food and Chemical Toxicology 110(Suppl. 1). p.234-241
Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental... (More)

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization
in
Food and Chemical Toxicology
volume
110
issue
Suppl. 1
pages
234 - 241
publisher
Elsevier
external identifiers
  • scopus:85020106945
  • pmid:28576467
ISSN
0278-6915
DOI
10.1016/j.fct.2017.05.066
language
English
LU publication?
no
id
3d7fd6de-b73c-465e-a75b-d03e4060d8a1
date added to LUP
2017-06-29 11:08:26
date last changed
2024-02-29 17:37:44
@article{3d7fd6de-b73c-465e-a75b-d03e4060d8a1,
  abstract     = {{<p>The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE &gt; 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.</p>}},
  author       = {{Api, A M and Belsito, D and Botelho, D. and Browne, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Calow, P. and Dagli, M L and Date, M. and Dekant, W. and Deodhar, C. and Fryer, A. D. and Joshi, K. D. and La Cava, S and Lapczynski, A and Liebler, D C and O'Brien, Kevin D. and Parakhia, R. and Patel, A. and Penning, T. M. and Ritacco, G and Romine, J. and Salvito, D and Schultz, T W and Sipes, I G and Thakkar, Y. and Tsang, Shui Lung and Wahler, J.}},
  issn         = {{0278-6915}},
  keywords     = {{Developmental and reproductive toxicity; Environmental safety; Genotoxicity; Local respiratory toxicity; Phototoxicity/photoallergenicity; Repeated dose; Skin sensitization}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{Suppl. 1}},
  pages        = {{234--241}},
  publisher    = {{Elsevier}},
  series       = {{Food and Chemical Toxicology}},
  title        = {{RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2017.05.066}},
  doi          = {{10.1016/j.fct.2017.05.066}},
  volume       = {{110}},
  year         = {{2017}},
}