Effects of a lipid lowering fibrate and hormone replacement therapy on serum lipids and lipoproteins in overweight postmenopausal women with elevated triglycerides.

Nerbrand, Christina; Nyberg, Per; Nordström, Lennart; Samsioe, Göran

Effects of a lipid lowering fibrate and hormone replacement therapy on serum lipids and lipoproteins in overweight postmenopausal women with elevated triglycerides.

Mark

Nerbrand, Christina ^LU ; Nyberg, Per ^LU ; Nordström, Lennart and Samsioe, Göran ^LU (2002) In Maturitas 42(1). p.55-62

Abstract: BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant further evaluation especially when combined with other lipid lowering drugs. STUDY DESIGN: Postmenopausal women were studied by an open randomised study during 9 months. Subjects were recruited from outpatient clinics in a rural area of Sweden. Major inclusive criteria comprised body mass index (BMI) >28, serum triglycerides >1.5 mmol/l. Participants were at least 12 months postmenopause with a concomitant serum Follicle... (More); BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant further evaluation especially when combined with other lipid lowering drugs. STUDY DESIGN: Postmenopausal women were studied by an open randomised study during 9 months. Subjects were recruited from outpatient clinics in a rural area of Sweden. Major inclusive criteria comprised body mass index (BMI) >28, serum triglycerides >1.5 mmol/l. Participants were at least 12 months postmenopause with a concomitant serum Follicle Stimulating Hormone (FSH) above 28 IU/l. After inclusion in the study patients were instructed to adhere to a low-fat and caloric diet for 3 months and after this period randomised into two groups of intervention; a lipidlowering fibrate (LLF) group and one hormone replacement therapy group (HRT). The LLF group was given gemfibrozil 600 mg orally twice daily and HRT group received 2 mg oestradiol in combination with 1 mg norethisterone acetate as a continuous combined therapy once daily. After 3 months, the LLF group added the HRT regimen and patients in the HRT group added gemfibrozil. Hence, all participants received the regimens combined for the last 6 months of the study. RESULTS: Serum s-cholesterol was markedly decreased in both groups during the first 3 months of single treatment (P<0.0001). This decrease reflected a reduction especially of calculated low density lipoprotein (LDL) s-cholesterol (P<0.001). High density lipoprotein (HDL) s-cholesterol was reduced in the HRT group (P<0.005) but increased (P<0.004) in the LLF group. Triglycerides were also decreased by both treatments but more marked in the LLF group (P<0.0001) than in the HRT group (P<0.02). After 9 months the reduction remained in both groups but no additive effects were encountered in any of the groups. CONCLUSION: The effects by gemfibrozil on s-cholesterol and triglycerides levels seem to be superior to continuous combined HRT in overweight women with elevated triglycerides. The combination of the two drugs did not seem to offer any additional benefit concerning the routine serum lipid or lipoprotein profile. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/108323

author

Nerbrand, Christina ^LU ; Nyberg, Per ^LU ; Nordström, Lennart and Samsioe, Göran ^LU

organization

publishing date

2002

type

Contribution to journal

publication status

published

subject

Obstetrics, Gynecology and Reproductive Medicine

keywords

Female, Estrogen Replacement Therapy, Estradiol : therapeutic use, Estradiol : administration & dosage, Cholesterol : blood, Cardiovascular Diseases : prevention & control, Antilipemic Agents : therapeutic use, Antilipemic Agents : administration & dosage, Oral, Administration, Lipoproteins, HDL Cholesterol : drug effects, LDL Cholesterol : blood, Middle Age, LDL Cholesterol : drug effects, Norethindrone : administration & dosage, Norethindrone : therapeutic use, Obesity : complications, Postmenopause, Triglycerides : blood, Treatment Outcome, Support, Non-U.S. Gov't, Gemfibrozil : administration & dosage, Gemfibrozil : therapeutic use, Human, Hyperlipidemia : complications, Hyperlipidemia : prevention & control, Lipoproteins : blood, Lipoproteins : drug effects, HDL Cholesterol : blood

in

Maturitas

volume

42

issue

1

pages

55 - 62

publisher

Elsevier

external identifiers

pmid:12020980
wos:000176531000007
scopus:0037140679

ISSN

1873-4111

DOI

10.1016/S0378-5122(01)00302-4

language

English

LU publication?

yes

id

3da4507e-9f0e-4407-b958-57059cb1446a (old id 108323)

alternative location

http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12020980&dopt=Abstract

date added to LUP

2016-04-01 11:56:35

date last changed

2022-01-26 20:32:48

@article{3da4507e-9f0e-4407-b958-57059cb1446a,
  abstract     = {{BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant further evaluation especially when combined with other lipid lowering drugs. STUDY DESIGN: Postmenopausal women were studied by an open randomised study during 9 months. Subjects were recruited from outpatient clinics in a rural area of Sweden. Major inclusive criteria comprised body mass index (BMI) &gt;28, serum triglycerides &gt;1.5 mmol/l. Participants were at least 12 months postmenopause with a concomitant serum Follicle Stimulating Hormone (FSH) above 28 IU/l. After inclusion in the study patients were instructed to adhere to a low-fat and caloric diet for 3 months and after this period randomised into two groups of intervention; a lipidlowering fibrate (LLF) group and one hormone replacement therapy group (HRT). The LLF group was given gemfibrozil 600 mg orally twice daily and HRT group received 2 mg oestradiol in combination with 1 mg norethisterone acetate as a continuous combined therapy once daily. After 3 months, the LLF group added the HRT regimen and patients in the HRT group added gemfibrozil. Hence, all participants received the regimens combined for the last 6 months of the study. RESULTS: Serum s-cholesterol was markedly decreased in both groups during the first 3 months of single treatment (P&lt;0.0001). This decrease reflected a reduction especially of calculated low density lipoprotein (LDL) s-cholesterol (P&lt;0.001). High density lipoprotein (HDL) s-cholesterol was reduced in the HRT group (P&lt;0.005) but increased (P&lt;0.004) in the LLF group. Triglycerides were also decreased by both treatments but more marked in the LLF group (P&lt;0.0001) than in the HRT group (P&lt;0.02). After 9 months the reduction remained in both groups but no additive effects were encountered in any of the groups. CONCLUSION: The effects by gemfibrozil on s-cholesterol and triglycerides levels seem to be superior to continuous combined HRT in overweight women with elevated triglycerides. The combination of the two drugs did not seem to offer any additional benefit concerning the routine serum lipid or lipoprotein profile.}},
  author       = {{Nerbrand, Christina and Nyberg, Per and Nordström, Lennart and Samsioe, Göran}},
  issn         = {{1873-4111}},
  keywords     = {{Female; Estrogen Replacement Therapy; Estradiol : therapeutic use; Estradiol : administration & dosage; Cholesterol : blood; Cardiovascular Diseases : prevention & control; Antilipemic Agents : therapeutic use; Antilipemic Agents : administration & dosage; Oral; Administration; Lipoproteins; HDL Cholesterol : drug effects; LDL Cholesterol : blood; Middle Age; LDL Cholesterol : drug effects; Norethindrone : administration & dosage; Norethindrone : therapeutic use; Obesity : complications; Postmenopause; Triglycerides : blood; Treatment Outcome; Support; Non-U.S. Gov't; Gemfibrozil : administration & dosage; Gemfibrozil : therapeutic use; Human; Hyperlipidemia : complications; Hyperlipidemia : prevention & control; Lipoproteins : blood; Lipoproteins : drug effects; HDL Cholesterol : blood}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{55--62}},
  publisher    = {{Elsevier}},
  series       = {{Maturitas}},
  title        = {{Effects of a lipid lowering fibrate and hormone replacement therapy on serum lipids and lipoproteins in overweight postmenopausal women with elevated triglycerides.}},
  url          = {{http://dx.doi.org/10.1016/S0378-5122(01)00302-4}},
  doi          = {{10.1016/S0378-5122(01)00302-4}},
  volume       = {{42}},
  year         = {{2002}},
}

Lund University Publications

LUND UNIVERSITY LIBRARIES

Effects of a lipid lowering fibrate and hormone replacement therapy on serum lipids and lipoproteins in overweight postmenopausal women with elevated triglycerides.