Low vitamin d levels and frailty status in older adults : A systematic review and meta-analysis
(2020) In Nutrients 12(8).- Abstract
Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried’s phenotype to identify frailty. Twenty-six... (More)
Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried’s phenotype to identify frailty. Twenty-six studies were considered in the qualitative synthesis, and thirteen studies were included in the meta-analyses. Quantitative analyses showed significant differences in the comparisons of frail (standardized mean difference (SMD)—1.31, 95% confidence interval (CI) (−2.47, −0.15), p = 0.0271) and pre-frail (SMD—0.79, 95% CI (−1.58, −0.003), p = 0.0491) subjects vs. non-frail subjects. Sensitivity analyses reduced heterogeneity, resulting in a smaller but still highly significant between-groups difference. Results obtained indicate that lower 25(OH)D levels are significantly associated with increasing frailty severity. Future challenges include interventional studies testing the possible benefits of vitamin D supplementation in older adults to prevent/palliate frailty and its associated outcomes.
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- author
- Marcos-Pérez, Diego ; Sánchez-Flores, María ; Proietti, Stefania ; Bonassi, Stefano ; Costa, Solange ; Teixeira, Joao Paulo ; Fernández-Tajes, Juan LU ; Pásaro, Eduardo ; Valdiglesias, Vanessa and Laffon, Blanca
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Frailty, Meta-analysis, Older adults, Systematic review, Vitamin D
- in
- Nutrients
- volume
- 12
- issue
- 8
- article number
- 2286
- pages
- 20 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85088941046
- pmid:32751730
- ISSN
- 2072-6643
- DOI
- 10.3390/nu12082286
- language
- English
- LU publication?
- yes
- id
- 3dc56d33-c716-435e-9d63-bcb14e4dbbe7
- date added to LUP
- 2020-08-12 10:13:06
- date last changed
- 2024-03-05 00:41:10
@article{3dc56d33-c716-435e-9d63-bcb14e4dbbe7,
abstract = {{<p>Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried’s phenotype to identify frailty. Twenty-six studies were considered in the qualitative synthesis, and thirteen studies were included in the meta-analyses. Quantitative analyses showed significant differences in the comparisons of frail (standardized mean difference (SMD)—1.31, 95% confidence interval (CI) (−2.47, −0.15), p = 0.0271) and pre-frail (SMD—0.79, 95% CI (−1.58, −0.003), p = 0.0491) subjects vs. non-frail subjects. Sensitivity analyses reduced heterogeneity, resulting in a smaller but still highly significant between-groups difference. Results obtained indicate that lower 25(OH)D levels are significantly associated with increasing frailty severity. Future challenges include interventional studies testing the possible benefits of vitamin D supplementation in older adults to prevent/palliate frailty and its associated outcomes.</p>}},
author = {{Marcos-Pérez, Diego and Sánchez-Flores, María and Proietti, Stefania and Bonassi, Stefano and Costa, Solange and Teixeira, Joao Paulo and Fernández-Tajes, Juan and Pásaro, Eduardo and Valdiglesias, Vanessa and Laffon, Blanca}},
issn = {{2072-6643}},
keywords = {{Frailty; Meta-analysis; Older adults; Systematic review; Vitamin D}},
language = {{eng}},
number = {{8}},
publisher = {{MDPI AG}},
series = {{Nutrients}},
title = {{Low vitamin d levels and frailty status in older adults : A systematic review and meta-analysis}},
url = {{http://dx.doi.org/10.3390/nu12082286}},
doi = {{10.3390/nu12082286}},
volume = {{12}},
year = {{2020}},
}