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Consensus guidelines for lumbar puncture in patients with neurological diseases

Engelborghs, Sebastiaan ; Niemantsverdriet, Ellis ; Struyfs, Hanne ; Blennow, Kaj LU ; Brouns, Raf ; Comabella, Manuel ; Dujmovic, Irena ; van der Flier, Wiesje ; Frölich, Lutz and Galimberti, Daniela , et al. (2017) In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 8. p.111-126
Abstract

Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers... (More)

Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Back pain, Cerebrospinal fluid, Consensus guidelines, Evidence-based guidelines, Headache, Lumbar puncture, Post-LP complications
in
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
volume
8
pages
16 pages
publisher
Elsevier
external identifiers
  • pmid:28603768
  • scopus:85020024963
ISSN
2352-8729
DOI
10.1016/j.dadm.2017.04.007
language
English
LU publication?
yes
id
3de64c8b-293d-4349-8281-84463a540f04
date added to LUP
2017-06-26 14:49:29
date last changed
2025-03-03 19:52:58
@article{3de64c8b-293d-4349-8281-84463a540f04,
  abstract     = {{<p>Introduction Cerebrospinal fluid collection by lumbar puncture (LP) is performed in the diagnostic workup of several neurological brain diseases. Reluctance to perform the procedure is among others due to a lack of standards and guidelines to minimize the risk of complications, such as post-LP headache or back pain. Methods We provide consensus guidelines for the LP procedure to minimize the risk of complications. The recommendations are based on (1) data from a large multicenter LP feasibility study (evidence level II-2), (2) systematic literature review on LP needle characteristics and post-LP complications (evidence level II-2), (3) discussion of best practice within the Joint Programme Neurodegenerative Disease Research Biomarkers for Alzheimer's disease and Parkinson's Disease and Biomarkers for Multiple Sclerosis consortia (evidence level III). Results Our consensus guidelines address contraindications, as well as patient-related and procedure-related risk factors that can influence the development of post-LP complications. Discussion When an LP is performed correctly, the procedure is well tolerated and accepted with a low complication rate.</p>}},
  author       = {{Engelborghs, Sebastiaan and Niemantsverdriet, Ellis and Struyfs, Hanne and Blennow, Kaj and Brouns, Raf and Comabella, Manuel and Dujmovic, Irena and van der Flier, Wiesje and Frölich, Lutz and Galimberti, Daniela and Gnanapavan, Sharmilee and Hemmer, Bernhard and Hoff, Erik I and Hort, Jakub and Iacobaeus, Ellen and Ingelsson, Martin and Jan de Jong, Frank and Jonsson, Michael and Khalil, Michael and Kuhle, Jens and Lleó, Alberto and de Mendonça, Alexandre and Molinuevo, José Luis and Nagels, Guy and Paquet, Claire and Parnetti, Lucilla and Roks, Gerwin and Rosa-Neto, Pedro and Scheltens, Philip and Skårsgard, Constance and Stomrud, Erik and Tumani, Hayrettin and Visser, Pieter Jelle and Wallin, Anders and Winblad, Bengt and Zetterberg, Henrik and Duits, Flora H and Teunissen, Charlotte E}},
  issn         = {{2352-8729}},
  keywords     = {{Back pain; Cerebrospinal fluid; Consensus guidelines; Evidence-based guidelines; Headache; Lumbar puncture; Post-LP complications}},
  language     = {{eng}},
  pages        = {{111--126}},
  publisher    = {{Elsevier}},
  series       = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}},
  title        = {{Consensus guidelines for lumbar puncture in patients with neurological diseases}},
  url          = {{http://dx.doi.org/10.1016/j.dadm.2017.04.007}},
  doi          = {{10.1016/j.dadm.2017.04.007}},
  volume       = {{8}},
  year         = {{2017}},
}