Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, Catharina LU ; Gonzalez, Hugo ; Salari, Kiarash ; Wang, Chih Yang ; Lin, Charlene ; Robles, Isabella ; van Gogh, Merel ; Dejmek, Annika LU ; Jirström, Karin LU orcid and Werb, Zena (2019) In Proceedings of the National Academy of Sciences of the United States of America 116(43). p.21704-21714
Abstract

Metastatic behavior varies significantly among breast cancers. Mechanisms explaining why the majority of breast cancer patients never develop metastatic outgrowth are largely lacking but could underlie the development of novel immunotherapeutic target molecules. Here we show interplay between nonmetastatic primary breast cancer and innate immune response, acting together to control metastatic progression. The primary tumor systemically recruits IFNγ-producing immune effector monocytes to the lung. IFNγ up-regulates Tmem173/ STING in neutrophils and enhances their killing capacity. The immune effector monocytes and tumoricidal neutrophils target disseminated tumor cells in the lungs, preventing metastatic outgrowth. Importantly, our... (More)

Metastatic behavior varies significantly among breast cancers. Mechanisms explaining why the majority of breast cancer patients never develop metastatic outgrowth are largely lacking but could underlie the development of novel immunotherapeutic target molecules. Here we show interplay between nonmetastatic primary breast cancer and innate immune response, acting together to control metastatic progression. The primary tumor systemically recruits IFNγ-producing immune effector monocytes to the lung. IFNγ up-regulates Tmem173/ STING in neutrophils and enhances their killing capacity. The immune effector monocytes and tumoricidal neutrophils target disseminated tumor cells in the lungs, preventing metastatic outgrowth. Importantly, our findings could underlie the development of immunotherapeutic target molecules that augment the function of immune effector monocytes and neutrophils.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CCL2, CCR2, Immune effector monocytes, Metastatic breast cancer, STING
in
Proceedings of the National Academy of Sciences of the United States of America
volume
116
issue
43
pages
11 pages
publisher
National Academy of Sciences
external identifiers
  • scopus:85073708969
  • pmid:31591235
ISSN
0027-8424
DOI
10.1073/pnas.1907660116
language
English
LU publication?
yes
id
3e20ebd5-85be-4368-9b5b-d81e57f2fd93
date added to LUP
2019-10-30 08:06:35
date last changed
2024-02-16 00:42:30
@article{3e20ebd5-85be-4368-9b5b-d81e57f2fd93,
  abstract     = {{<p>Metastatic behavior varies significantly among breast cancers. Mechanisms explaining why the majority of breast cancer patients never develop metastatic outgrowth are largely lacking but could underlie the development of novel immunotherapeutic target molecules. Here we show interplay between nonmetastatic primary breast cancer and innate immune response, acting together to control metastatic progression. The primary tumor systemically recruits IFNγ-producing immune effector monocytes to the lung. IFNγ up-regulates Tmem173/ STING in neutrophils and enhances their killing capacity. The immune effector monocytes and tumoricidal neutrophils target disseminated tumor cells in the lungs, preventing metastatic outgrowth. Importantly, our findings could underlie the development of immunotherapeutic target molecules that augment the function of immune effector monocytes and neutrophils.</p>}},
  author       = {{Hagerling, Catharina and Gonzalez, Hugo and Salari, Kiarash and Wang, Chih Yang and Lin, Charlene and Robles, Isabella and van Gogh, Merel and Dejmek, Annika and Jirström, Karin and Werb, Zena}},
  issn         = {{0027-8424}},
  keywords     = {{CCL2; CCR2; Immune effector monocytes; Metastatic breast cancer; STING}},
  language     = {{eng}},
  number       = {{43}},
  pages        = {{21704--21714}},
  publisher    = {{National Academy of Sciences}},
  series       = {{Proceedings of the National Academy of Sciences of the United States of America}},
  title        = {{Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer}},
  url          = {{http://dx.doi.org/10.1073/pnas.1907660116}},
  doi          = {{10.1073/pnas.1907660116}},
  volume       = {{116}},
  year         = {{2019}},
}