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A microwave-assisted solution combustion synthesis to produce europium-doped calcium phosphate nanowhiskers for bioimaging applications

Wagner, Darcy E. LU ; Eisenmann, Kathryn M.; Nestor-Kalinoski, Andrea L. and Bhaduri, Sarit B. (2013) In Acta Biomaterialia 9(9). p.8422-8432
Abstract

Biocompatible nanoparticles possessing fluorescent properties offer attractive possibilities for multifunctional bioimaging and/or drug and gene delivery applications. Many of the limitations with current imaging systems center on the properties of the optical probes in relation to equipment technical capabilities. Here we introduce a novel high aspect ratio and highly crystalline europium-doped calcium phosphate nanowhisker produced using a simple microwave-assisted solution combustion synthesis method for use as a multifunctional bioimaging probe. X-ray diffraction confirmed the material phase as europium-doped hydroxyapatite. Fluorescence emission and excitation spectra and their corresponding peaks were identified using... (More)

Biocompatible nanoparticles possessing fluorescent properties offer attractive possibilities for multifunctional bioimaging and/or drug and gene delivery applications. Many of the limitations with current imaging systems center on the properties of the optical probes in relation to equipment technical capabilities. Here we introduce a novel high aspect ratio and highly crystalline europium-doped calcium phosphate nanowhisker produced using a simple microwave-assisted solution combustion synthesis method for use as a multifunctional bioimaging probe. X-ray diffraction confirmed the material phase as europium-doped hydroxyapatite. Fluorescence emission and excitation spectra and their corresponding peaks were identified using spectrofluorimetry and validated with fluorescence, confocal and multiphoton microscopy. The nanowhiskers were found to exhibit red and far red wavelength fluorescence under ultraviolet excitation with an optimal peak emission of 696 nm achieved with a 350 nm excitation. Relatively narrow emission bands were observed, which may permit their use in multicolor imaging applications. Confocal and multiphoton microscopy confirmed that the nanoparticles provide sufficient intensity to be utilized in imaging applications.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Europium Calcium phosphate, Fluorescence, Inorganic nanoparticles, Microwave-assisted solution synthesis
in
Acta Biomaterialia
volume
9
issue
9
pages
8422 - 8432
publisher
Elsevier
external identifiers
  • scopus:84880921879
ISSN
1742-7061
DOI
10.1016/j.actbio.2013.05.033
language
English
LU publication?
no
id
3e4a1a95-aa34-4b32-8165-d1d098a033fe
date added to LUP
2017-08-15 14:48:39
date last changed
2018-05-29 12:00:55
@article{3e4a1a95-aa34-4b32-8165-d1d098a033fe,
  abstract     = {<p>Biocompatible nanoparticles possessing fluorescent properties offer attractive possibilities for multifunctional bioimaging and/or drug and gene delivery applications. Many of the limitations with current imaging systems center on the properties of the optical probes in relation to equipment technical capabilities. Here we introduce a novel high aspect ratio and highly crystalline europium-doped calcium phosphate nanowhisker produced using a simple microwave-assisted solution combustion synthesis method for use as a multifunctional bioimaging probe. X-ray diffraction confirmed the material phase as europium-doped hydroxyapatite. Fluorescence emission and excitation spectra and their corresponding peaks were identified using spectrofluorimetry and validated with fluorescence, confocal and multiphoton microscopy. The nanowhiskers were found to exhibit red and far red wavelength fluorescence under ultraviolet excitation with an optimal peak emission of 696 nm achieved with a 350 nm excitation. Relatively narrow emission bands were observed, which may permit their use in multicolor imaging applications. Confocal and multiphoton microscopy confirmed that the nanoparticles provide sufficient intensity to be utilized in imaging applications.</p>},
  author       = {Wagner, Darcy E. and Eisenmann, Kathryn M. and Nestor-Kalinoski, Andrea L. and Bhaduri, Sarit B.},
  issn         = {1742-7061},
  keyword      = {Europium Calcium phosphate,Fluorescence,Inorganic nanoparticles,Microwave-assisted solution synthesis},
  language     = {eng},
  number       = {9},
  pages        = {8422--8432},
  publisher    = {Elsevier},
  series       = {Acta Biomaterialia},
  title        = {A microwave-assisted solution combustion synthesis to produce europium-doped calcium phosphate nanowhiskers for bioimaging applications},
  url          = {http://dx.doi.org/10.1016/j.actbio.2013.05.033},
  volume       = {9},
  year         = {2013},
}