Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study
(2011) In Cancer Causes and Control 22(2). p.291-299- Abstract
- To assess the association between serum triglyceride levels and cancer risk. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio. Relative risk for top... (More)
- To assess the association between serum triglyceride levels and cancer risk. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio. Relative risk for top quintile versus bottom quintile of triglycerides of overall cancer was 1.16 (95% confidence interval 1.06-1.26) in men and 1.15 (1.05-1.27) in women. For specific cancers, significant increases for top quintile versus bottom quintile of triglycerides among men were found for cancers of the colon, respiratory tract, the kidney, melanoma and thyroid and among women, for respiratory, cervical, and non-melanoma skin cancers. Data from our study provided evidence for a possible role of serum triglycerides in cancer development. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1790825
- author
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Lipids, Prospective study, Cancer incidence
- in
- Cancer Causes and Control
- volume
- 22
- issue
- 2
- pages
- 291 - 299
- publisher
- Springer
- external identifiers
-
- wos:000286465000014
- scopus:79951725594
- pmid:21140204
- ISSN
- 1573-7225
- DOI
- 10.1007/s10552-010-9697-0
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Surgery Research Unit (013242220)
- id
- 3e4b953a-34ab-4d88-8eed-586fed6cc26c (old id 1790825)
- date added to LUP
- 2016-04-01 10:26:52
- date last changed
- 2022-04-20 02:17:13
@article{3e4b953a-34ab-4d88-8eed-586fed6cc26c, abstract = {{To assess the association between serum triglyceride levels and cancer risk. The metabolic syndrome and cancer project (Me-Can) includes cohorts from Norway, Austria, and Sweden; the current study included data on 257,585 men and 256,512 women. The mean age at study entry was 43.8 years for men and 44.2 years for women. The mean follow-up time was 13.4 years (SD = 8.5) for men and 11.9 years (SD = 7.2) for women. Excluding the first year of follow-up, 23,060 men and 15,686 women were diagnosed with cancer. Cox regression models were used to calculate relative risk (RR) of cancer for triglyceride levels in quintiles and as a continuous variable. RRs were corrected for random error by use of regression dilution ratio. Relative risk for top quintile versus bottom quintile of triglycerides of overall cancer was 1.16 (95% confidence interval 1.06-1.26) in men and 1.15 (1.05-1.27) in women. For specific cancers, significant increases for top quintile versus bottom quintile of triglycerides among men were found for cancers of the colon, respiratory tract, the kidney, melanoma and thyroid and among women, for respiratory, cervical, and non-melanoma skin cancers. Data from our study provided evidence for a possible role of serum triglycerides in cancer development.}}, author = {{Borena, Wegene and Stocks, Tanja and Jonsson, Hakan and Strohmaier, Susanne and Nagel, Gabriele and Bjorge, Tone and Manjer, Jonas and Hallmans, Goeran and Selmer, Randi and Almquist, Martin and Haggstrom, Christel and Engeland, Anders and Tretli, Steinar and Concin, Hans and Strasak, Alexander and Stattin, Paer and Ulmer, Hanno}}, issn = {{1573-7225}}, keywords = {{Lipids; Prospective study; Cancer incidence}}, language = {{eng}}, number = {{2}}, pages = {{291--299}}, publisher = {{Springer}}, series = {{Cancer Causes and Control}}, title = {{Serum triglycerides and cancer risk in the metabolic syndrome and cancer (Me-Can) collaborative study}}, url = {{http://dx.doi.org/10.1007/s10552-010-9697-0}}, doi = {{10.1007/s10552-010-9697-0}}, volume = {{22}}, year = {{2011}}, }