Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang, Z. ; Schulz, C.-A. LU ; Sonestedt, E. LU
; Orho-Melander, M.
LU
and Hoed, M.
(2022)
In Nature Genetics
54(9).
p.1332-1344
- Abstract
- Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection... (More)
- Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. © 2022, The Author(s). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3ed8047d-6831-4b5c-acd0-5ca8bf379b56
- author
- Wang, Z.
; Schulz, C.-A.
LU
; Sonestedt, E.
LU
; Orho-Melander, M.
LU
and Hoed, M.
- author collaboration
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Genetics
- volume
- 54
- issue
- 9
- pages
- 13 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85137511928
- pmid:36071172
- ISSN
- 1061-4036
- DOI
- 10.1038/s41588-022-01165-1
- language
- English
- LU publication?
- yes
- id
- 3ed8047d-6831-4b5c-acd0-5ca8bf379b56
- date added to LUP
- 2022-12-19 14:20:56
- date last changed
- 2022-12-20 03:00:06
@article{3ed8047d-6831-4b5c-acd0-5ca8bf379b56,
abstract = {{Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention. © 2022, The Author(s).}},
author = {{Wang, Z. and Schulz, C.-A. and Sonestedt, E. and Orho-Melander, M. and Hoed, M.}},
issn = {{1061-4036}},
language = {{eng}},
number = {{9}},
pages = {{1332--1344}},
publisher = {{Nature Publishing Group}},
series = {{Nature Genetics}},
title = {{Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention}},
url = {{http://dx.doi.org/10.1038/s41588-022-01165-1}},
doi = {{10.1038/s41588-022-01165-1}},
volume = {{54}},
year = {{2022}},
}