Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Cell morphology and deformability in deterministic lateral displacement devices

Beech, Jason P. LU ; Adolfsson, Karl LU ; Holm, Stefan H. LU and Tegenfeldt, Jonas O. LU orcid (2011) 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 2. p.1355-1357
Abstract

Deterministic Lateral Displacement (DLD) devices have been used to separate particles based on size [1] and shape [2]. Here we show how DLD devices can also be used to separate particles based on their ability to deform under shear forces. Varying experimental conditions allows us to vary the relative contributions of size, morphology and deformability. The ability to distinguish between cells based on deformability with high resolution and throughput, in cheap and simple devices, could find highly interesting and relevant applications, for example in the detection of circulating tumor cells or malaria-infected blood cells.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Deformability, Deterministic lateral displacement, Morphology, Separation
host publication
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
volume
2
pages
3 pages
conference name
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
conference location
Seattle, WA, United States
conference dates
2011-10-02 - 2011-10-06
external identifiers
  • scopus:84883775989
ISBN
9781618395955
language
English
LU publication?
yes
id
3ed9e680-c253-4205-b15e-85963aee46c6
date added to LUP
2018-10-20 09:01:12
date last changed
2021-08-04 04:06:20
@inproceedings{3ed9e680-c253-4205-b15e-85963aee46c6,
  abstract     = {<p>Deterministic Lateral Displacement (DLD) devices have been used to separate particles based on size [1] and shape [2]. Here we show how DLD devices can also be used to separate particles based on their ability to deform under shear forces. Varying experimental conditions allows us to vary the relative contributions of size, morphology and deformability. The ability to distinguish between cells based on deformability with high resolution and throughput, in cheap and simple devices, could find highly interesting and relevant applications, for example in the detection of circulating tumor cells or malaria-infected blood cells.</p>},
  author       = {Beech, Jason P. and Adolfsson, Karl and Holm, Stefan H. and Tegenfeldt, Jonas O.},
  booktitle    = {15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011},
  isbn         = {9781618395955},
  language     = {eng},
  month        = {12},
  pages        = {1355--1357},
  title        = {Cell morphology and deformability in deterministic lateral displacement devices},
  volume       = {2},
  year         = {2011},
}