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High platelet count is associated with low bone mineral density : The MrOS Sweden cohort

Kristjansdottir, H. L. ; Mellström, D. ; Johansson, P. ; Karlsson, M. LU ; Vandenput, L. ; Lorentzon, M. ; Herlitz, H. ; Ohlsson, C. ; Lerner, U. H. and Lewerin, C. (2021) In Osteoporosis International 32(5). p.865-871
Abstract

Summary: In elderly ambulatory men, high platelet and high neutrophil counts are related to low bone mineral density (BMD), after adjustment for relevant covariates. Low hemoglobin (hgb) is even associated with low BMD, but this relationship seems to be dependent on estradiol and osteocalcin. Purpose: Blood and bone cells exist in close proximity to each other in the bone marrow. Accumulating evidence, from both preclinical and clinical studies, indicates that these cell types are interconnected. Our hypothesis was that BMD measurements are associated with blood count variables and bone remodeling markers. Methods: We analyzed blood count variables, bone remodeling markers, and BMD, in subjects from the MrOS cohort from Gothenburg,... (More)

Summary: In elderly ambulatory men, high platelet and high neutrophil counts are related to low bone mineral density (BMD), after adjustment for relevant covariates. Low hemoglobin (hgb) is even associated with low BMD, but this relationship seems to be dependent on estradiol and osteocalcin. Purpose: Blood and bone cells exist in close proximity to each other in the bone marrow. Accumulating evidence, from both preclinical and clinical studies, indicates that these cell types are interconnected. Our hypothesis was that BMD measurements are associated with blood count variables and bone remodeling markers. Methods: We analyzed blood count variables, bone remodeling markers, and BMD, in subjects from the MrOS cohort from Gothenburg, Sweden. Men with at least one blood count variable (hgb, white blood cell count, or platelet count) analyzed were included in the current analysis (n = 1005), median age 75.3 years (range 69–81 years). Results: Our results show that high platelet counts were related to low BMD at all sites (total hip BMD; r = − 0.11, P = 0.003). No statistically significant association was seen between platelet counts and bone remodeling markers. Neutrophil counts were negatively associated with total body BMD (r = − 0.09, P = 0.006) and total hip BMD (r = − 0.08, P = 0.010), and positively related to serum ALP (r = 0.15, P < 0.001). Hgb was positively related to total hip BMD (r = 0.16, P < 0.001), and negatively to serum osteocalcin (r = − 0.13, P < 0.001). The association between platelet and neutrophil counts and total hip BMD was statistically significant after adjustments for other covariates, but the association between hgb and total hip BMD was dependent on estradiol and osteocalcin. Conclusions: Our observations support the hypothesis of an interplay between blood and bone components.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Bone mineral density, Hematopoiesis, Hemoglobin, Platelet count, White blood cell count
in
Osteoporosis International
volume
32
issue
5
pages
865 - 871
publisher
Springer
external identifiers
  • scopus:85097508807
  • pmid:33313993
ISSN
0937-941X
DOI
10.1007/s00198-020-05766-6
language
English
LU publication?
yes
id
3f4f070c-ce6c-4861-8de2-5e14a9b985ca
date added to LUP
2020-12-23 09:04:55
date last changed
2024-03-05 16:19:12
@article{3f4f070c-ce6c-4861-8de2-5e14a9b985ca,
  abstract     = {{<p>Summary: In elderly ambulatory men, high platelet and high neutrophil counts are related to low bone mineral density (BMD), after adjustment for relevant covariates. Low hemoglobin (hgb) is even associated with low BMD, but this relationship seems to be dependent on estradiol and osteocalcin. Purpose: Blood and bone cells exist in close proximity to each other in the bone marrow. Accumulating evidence, from both preclinical and clinical studies, indicates that these cell types are interconnected. Our hypothesis was that BMD measurements are associated with blood count variables and bone remodeling markers. Methods: We analyzed blood count variables, bone remodeling markers, and BMD, in subjects from the MrOS cohort from Gothenburg, Sweden. Men with at least one blood count variable (hgb, white blood cell count, or platelet count) analyzed were included in the current analysis (n = 1005), median age 75.3 years (range 69–81 years). Results: Our results show that high platelet counts were related to low BMD at all sites (total hip BMD; r = − 0.11, P = 0.003). No statistically significant association was seen between platelet counts and bone remodeling markers. Neutrophil counts were negatively associated with total body BMD (r = − 0.09, P = 0.006) and total hip BMD (r = − 0.08, P = 0.010), and positively related to serum ALP (r = 0.15, P &lt; 0.001). Hgb was positively related to total hip BMD (r = 0.16, P &lt; 0.001), and negatively to serum osteocalcin (r = − 0.13, P &lt; 0.001). The association between platelet and neutrophil counts and total hip BMD was statistically significant after adjustments for other covariates, but the association between hgb and total hip BMD was dependent on estradiol and osteocalcin. Conclusions: Our observations support the hypothesis of an interplay between blood and bone components.</p>}},
  author       = {{Kristjansdottir, H. L. and Mellström, D. and Johansson, P. and Karlsson, M. and Vandenput, L. and Lorentzon, M. and Herlitz, H. and Ohlsson, C. and Lerner, U. H. and Lewerin, C.}},
  issn         = {{0937-941X}},
  keywords     = {{Aging; Bone mineral density; Hematopoiesis; Hemoglobin; Platelet count; White blood cell count}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{865--871}},
  publisher    = {{Springer}},
  series       = {{Osteoporosis International}},
  title        = {{High platelet count is associated with low bone mineral density : The MrOS Sweden cohort}},
  url          = {{http://dx.doi.org/10.1007/s00198-020-05766-6}},
  doi          = {{10.1007/s00198-020-05766-6}},
  volume       = {{32}},
  year         = {{2021}},
}