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Gender effects in familial cancer

Hemminki, Kari LU and Li, Xinjun LU (2002) In International Journal of Cancer 102(2). p.7-184
Abstract

Very limited data are available on sex ratios in familial cancer. Such data would be valuable in the assessment of sex chromosome effects and of interactions between background and familial rates. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and over 1 million neoplasms to analyze familial risks for male and female offspring by paternal and maternal concordant cancer. Sex ratios for familial cancer were derived for cancer at 15 sites shared by men and women. At 14 sites the sex ratio (male/female) for familial relative risk ranged between 0.78 and 1.41, with no evidence of sex preference, suggesting that sex chromosomes do not contribute to a noticeable extent to familial risks. Furthermore, in... (More)

Very limited data are available on sex ratios in familial cancer. Such data would be valuable in the assessment of sex chromosome effects and of interactions between background and familial rates. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and over 1 million neoplasms to analyze familial risks for male and female offspring by paternal and maternal concordant cancer. Sex ratios for familial cancer were derived for cancer at 15 sites shared by men and women. At 14 sites the sex ratio (male/female) for familial relative risk ranged between 0.78 and 1.41, with no evidence of sex preference, suggesting that sex chromosomes do not contribute to a noticeable extent to familial risks. Furthermore, in cancers where the background incidence varied extensively by sex, such as bladder cancer (sex ratio 2.82) and nonthyroid endocrine tumors (0.65), the familial effect was proportionate to the background incidence and the familial sex ratio was close to unity. In thyroid cancer, the familial sex ratio was 2.48 (1.54-3.98) and the background incidence ratio was 0.31. This was the first evidence of an inverse sex ratio in primary cancer, i.e., higher familial risk in the gender of low background risk. The high familial ratio, 2.85 (95% CI: 1.35-6.03), was due to thyroid adenocarcinoma, encompassing both papillary and follicular types.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adenocarcinoma/genetics, Female, Humans, Male, Neoplasms/genetics, Sex Ratio, Thyroid Neoplasms/genetics
in
International Journal of Cancer
volume
102
issue
2
pages
4 pages
publisher
John Wiley & Sons
external identifiers
  • pmid:12385016
  • scopus:0037058311
ISSN
0020-7136
DOI
10.1002/ijc.10676
language
English
LU publication?
no
id
3f7d0bd8-5564-437a-b506-734f2d68eba6
date added to LUP
2019-01-30 11:58:50
date last changed
2019-11-27 03:01:44
@article{3f7d0bd8-5564-437a-b506-734f2d68eba6,
  abstract     = {<p>Very limited data are available on sex ratios in familial cancer. Such data would be valuable in the assessment of sex chromosome effects and of interactions between background and familial rates. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and over 1 million neoplasms to analyze familial risks for male and female offspring by paternal and maternal concordant cancer. Sex ratios for familial cancer were derived for cancer at 15 sites shared by men and women. At 14 sites the sex ratio (male/female) for familial relative risk ranged between 0.78 and 1.41, with no evidence of sex preference, suggesting that sex chromosomes do not contribute to a noticeable extent to familial risks. Furthermore, in cancers where the background incidence varied extensively by sex, such as bladder cancer (sex ratio 2.82) and nonthyroid endocrine tumors (0.65), the familial effect was proportionate to the background incidence and the familial sex ratio was close to unity. In thyroid cancer, the familial sex ratio was 2.48 (1.54-3.98) and the background incidence ratio was 0.31. This was the first evidence of an inverse sex ratio in primary cancer, i.e., higher familial risk in the gender of low background risk. The high familial ratio, 2.85 (95% CI: 1.35-6.03), was due to thyroid adenocarcinoma, encompassing both papillary and follicular types.</p>},
  author       = {Hemminki, Kari and Li, Xinjun},
  issn         = {0020-7136},
  language     = {eng},
  month        = {11},
  number       = {2},
  pages        = {7--184},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Gender effects in familial cancer},
  url          = {http://dx.doi.org/10.1002/ijc.10676},
  doi          = {10.1002/ijc.10676},
  volume       = {102},
  year         = {2002},
}