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Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence?

Eriksson, Mikael LU orcid ; Reichardt, Peter ; Sundby Hall, Kirsten ; Schütte, Jochen ; Cameron, Silke ; Hohenberger, Peter ; Bauer, Sebastian ; Leinonen, Mika ; Reichardt, Annette and Rejmyr Davis, Maria , et al. (2016) In European Journal of Cancer 59. p.128-133
Abstract

PURPOSE: Preoperative percutaneous transabdominal wall biopsy may be considered to diagnose gastrointestinal stromal tumour (GIST) and plan preoperative treatment with tyrosine kinase inhibitors when an endoscopic biopsy is not possible. Hypothetically, a transabdominal wall biopsy might lead to cell seeding and conversion of a local GIST to a disseminated one. We investigated the influence of preoperative needle biopsy on survival outcomes.

METHODS: We collected the clinical data from hospital case records of the 397 patients who participated in the Scandinavian Sarcoma Group (SSG) XVIII/Arbeitsgemeinschaft Internistische Onkologie (AIO) randomised trial and who had a transabdominal fine needle and/or core needle biopsy carried... (More)

PURPOSE: Preoperative percutaneous transabdominal wall biopsy may be considered to diagnose gastrointestinal stromal tumour (GIST) and plan preoperative treatment with tyrosine kinase inhibitors when an endoscopic biopsy is not possible. Hypothetically, a transabdominal wall biopsy might lead to cell seeding and conversion of a local GIST to a disseminated one. We investigated the influence of preoperative needle biopsy on survival outcomes.

METHODS: We collected the clinical data from hospital case records of the 397 patients who participated in the Scandinavian Sarcoma Group (SSG) XVIII/Arbeitsgemeinschaft Internistische Onkologie (AIO) randomised trial and who had a transabdominal fine needle and/or core needle biopsy carried out prior to study entry. The SSG XVIII/AIO trial compared 1 and 3 years of adjuvant imatinib in a patient population with a high risk of GIST recurrence after macroscopically radical surgery. The primary end-point was recurrence-free survival (RFS), and the secondary end-points included overall survival (OS).

RESULTS: A total of 47 (12.0%) out of the 393 patients with data available underwent a percutaneous biopsy. No significant difference in RFS or OS was found between the patients who underwent or did not undergo a percutaneous biopsy either in the entire series or in subpopulation analyses, except for a statistically significant RFS advantage for patients who had a percutaneous biopsy and a tumour ≥10 cm in diameter.

CONCLUSION: A preoperative diagnostic percutaneous biopsy of a suspected GIST may not increase the risk for GIST recurrence in a patient population who receive adjuvant imatinib after the biopsy.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer
volume
59
pages
6 pages
publisher
Elsevier
external identifiers
  • pmid:27033260
  • scopus:84961938321
  • wos:000375138200014
ISSN
1879-0852
DOI
10.1016/j.ejca.2016.02.021
language
English
LU publication?
yes
id
3fa0e764-4962-4dfc-922a-ae35d0beec75
date added to LUP
2016-04-26 09:49:40
date last changed
2025-01-26 04:18:11
@article{3fa0e764-4962-4dfc-922a-ae35d0beec75,
  abstract     = {{<p>PURPOSE: Preoperative percutaneous transabdominal wall biopsy may be considered to diagnose gastrointestinal stromal tumour (GIST) and plan preoperative treatment with tyrosine kinase inhibitors when an endoscopic biopsy is not possible. Hypothetically, a transabdominal wall biopsy might lead to cell seeding and conversion of a local GIST to a disseminated one. We investigated the influence of preoperative needle biopsy on survival outcomes.</p><p>METHODS: We collected the clinical data from hospital case records of the 397 patients who participated in the Scandinavian Sarcoma Group (SSG) XVIII/Arbeitsgemeinschaft Internistische Onkologie (AIO) randomised trial and who had a transabdominal fine needle and/or core needle biopsy carried out prior to study entry. The SSG XVIII/AIO trial compared 1 and 3 years of adjuvant imatinib in a patient population with a high risk of GIST recurrence after macroscopically radical surgery. The primary end-point was recurrence-free survival (RFS), and the secondary end-points included overall survival (OS).</p><p>RESULTS: A total of 47 (12.0%) out of the 393 patients with data available underwent a percutaneous biopsy. No significant difference in RFS or OS was found between the patients who underwent or did not undergo a percutaneous biopsy either in the entire series or in subpopulation analyses, except for a statistically significant RFS advantage for patients who had a percutaneous biopsy and a tumour ≥10 cm in diameter.</p><p>CONCLUSION: A preoperative diagnostic percutaneous biopsy of a suspected GIST may not increase the risk for GIST recurrence in a patient population who receive adjuvant imatinib after the biopsy.</p>}},
  author       = {{Eriksson, Mikael and Reichardt, Peter and Sundby Hall, Kirsten and Schütte, Jochen and Cameron, Silke and Hohenberger, Peter and Bauer, Sebastian and Leinonen, Mika and Reichardt, Annette and Rejmyr Davis, Maria and Alvegård, Thor and Joensuu, Heikki}},
  issn         = {{1879-0852}},
  language     = {{eng}},
  pages        = {{128--133}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Cancer}},
  title        = {{Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence?}},
  url          = {{http://dx.doi.org/10.1016/j.ejca.2016.02.021}},
  doi          = {{10.1016/j.ejca.2016.02.021}},
  volume       = {{59}},
  year         = {{2016}},
}