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γ-Tubulin⁻γ-Tubulin Interactions as the Basis for the Formation of a Meshwork

Rosselló, Catalina Ana LU ; Lindström, Lisa LU ; Eklund, Greta LU ; Corvaisier, Matthieu LU and Kristensson, Maria Alvarado LU (2018) In International Journal of Molecular Sciences 19(10).
Abstract

In cytoplasm, protein γ-tubulin joins with various γ-tubulin complex proteins (GCPs) to form a heterotetramer γ-tubulin small complex (γ-TuSC) that can grow into a ring-shaped structure called the γ-tubulin ring complex (γ-TuRC). Both γ-TuSC and γ-TuRC are required for microtubule nucleation. Recent knowledge on γ-tubulin with regard to its cellular functions beyond participation in its creation of microtubules suggests that this protein forms a cellular meshwork. The present review summarizes the recognized functions of γ-tubulin and aims to unite the current views on this protein.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Molecular Sciences
volume
19
issue
10
publisher
MOLECULAR DIVERSITY PRESERVATION INT
external identifiers
  • scopus:85055183682
ISSN
1422-0067
DOI
10.3390/ijms19103245
language
English
LU publication?
yes
id
3fb22834-2aff-4f44-a777-7d3d130fc1c2
date added to LUP
2018-10-24 14:33:27
date last changed
2019-02-20 11:33:23
@article{3fb22834-2aff-4f44-a777-7d3d130fc1c2,
  abstract     = {<p>In cytoplasm, protein γ-tubulin joins with various γ-tubulin complex proteins (GCPs) to form a heterotetramer γ-tubulin small complex (γ-TuSC) that can grow into a ring-shaped structure called the γ-tubulin ring complex (γ-TuRC). Both γ-TuSC and γ-TuRC are required for microtubule nucleation. Recent knowledge on γ-tubulin with regard to its cellular functions beyond participation in its creation of microtubules suggests that this protein forms a cellular meshwork. The present review summarizes the recognized functions of γ-tubulin and aims to unite the current views on this protein.</p>},
  articleno    = {3245},
  author       = {Rosselló, Catalina Ana and Lindström, Lisa and Eklund, Greta and Corvaisier, Matthieu and Kristensson, Maria Alvarado},
  issn         = {1422-0067},
  language     = {eng},
  month        = {10},
  number       = {10},
  publisher    = {MOLECULAR DIVERSITY PRESERVATION INT},
  series       = {International Journal of Molecular Sciences},
  title        = {γ-Tubulin⁻γ-Tubulin Interactions as the Basis for the Formation of a Meshwork},
  url          = {http://dx.doi.org/10.3390/ijms19103245},
  volume       = {19},
  year         = {2018},
}