Cerebral excitatory amino acids and Na+,K+-ATPase activity during resuscitation of severely hypoxic newborn piglets
(1998) In Acta Pædiatrica 87(8). p.889-895- Abstract
- We tested the hypothesis that early brain recovery in hypoxic newborn piglets is improved by resuscitating with an O2 supply close to the minimum level required by the newborn piglet brain. Severely hypoxic 2-5-d-old anaesthetized piglets were randomly divided into three resuscitation groups: hypoxaemic (n = 8), 21% O2 (n = 8), and 100% O2 groups (n = 8). The hypoxaemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%, mean +/- SEM). During the 2h resuscitation period, extracellular aspartate and glutamate concentrations in the cerebral striatum were higher during hypoxaemic resuscitation (p = 0.044 and p = 0.055, respectively) than during resuscitation with... (More)
- We tested the hypothesis that early brain recovery in hypoxic newborn piglets is improved by resuscitating with an O2 supply close to the minimum level required by the newborn piglet brain. Severely hypoxic 2-5-d-old anaesthetized piglets were randomly divided into three resuscitation groups: hypoxaemic (n = 8), 21% O2 (n = 8), and 100% O2 groups (n = 8). The hypoxaemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%, mean +/- SEM). During the 2h resuscitation period, extracellular aspartate and glutamate concentrations in the cerebral striatum were higher during hypoxaemic resuscitation (p = 0.044 and p = 0.055, respectively) than during resuscitation with 21% O2 or 100% O2, suggesting an unfavourable accumulation of potent excitotoxins during hypoxaemic resuscitation. The cell membrane Na+,K+-ATPase activity of cerebral cortical tissue after 2 h resuscitation was similar in the three groups (p = 0.30). In conclusion, hypoxaemic resuscitation did not normalize early cerebral metabolic recovery as efficiently as resuscitation with 21% O2 or 100% O2. Resuscitation with 21% O2 was as efficient as resuscitation with 100% O2 in this newborn piglet hypoxia model. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1112708
- author
- Feet, B A ; Gilland, E ; Groenendaal, F ; Brun, N C ; Hellström-Westas, Lena LU ; Hagberg, H and Saugstad, O D
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hypoxanthine, in vivo microdialysis, Asphyxia, oxygen, reoxygenation
- in
- Acta Pædiatrica
- volume
- 87
- issue
- 8
- pages
- 889 - 895
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:9736239
- scopus:0031683655
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.1998.tb01557.x
- language
- English
- LU publication?
- yes
- id
- 3fc4a31f-4cfa-4e41-86a3-c8256a8bb2c4 (old id 1112708)
- alternative location
- http://www3.interscience.wiley.com/cgi-bin/fulltext/119942684/PDFSTART
- date added to LUP
- 2016-04-01 15:46:28
- date last changed
- 2022-01-28 07:00:25
@article{3fc4a31f-4cfa-4e41-86a3-c8256a8bb2c4, abstract = {{We tested the hypothesis that early brain recovery in hypoxic newborn piglets is improved by resuscitating with an O2 supply close to the minimum level required by the newborn piglet brain. Severely hypoxic 2-5-d-old anaesthetized piglets were randomly divided into three resuscitation groups: hypoxaemic (n = 8), 21% O2 (n = 8), and 100% O2 groups (n = 8). The hypoxaemic group was mechanically ventilated with 12-18% O2 adjusted to achieve a cerebral venous O2 saturation of 17-23% (baseline; 45 +/- 1%, mean +/- SEM). During the 2h resuscitation period, extracellular aspartate and glutamate concentrations in the cerebral striatum were higher during hypoxaemic resuscitation (p = 0.044 and p = 0.055, respectively) than during resuscitation with 21% O2 or 100% O2, suggesting an unfavourable accumulation of potent excitotoxins during hypoxaemic resuscitation. The cell membrane Na+,K+-ATPase activity of cerebral cortical tissue after 2 h resuscitation was similar in the three groups (p = 0.30). In conclusion, hypoxaemic resuscitation did not normalize early cerebral metabolic recovery as efficiently as resuscitation with 21% O2 or 100% O2. Resuscitation with 21% O2 was as efficient as resuscitation with 100% O2 in this newborn piglet hypoxia model.}}, author = {{Feet, B A and Gilland, E and Groenendaal, F and Brun, N C and Hellström-Westas, Lena and Hagberg, H and Saugstad, O D}}, issn = {{1651-2227}}, keywords = {{hypoxanthine; in vivo microdialysis; Asphyxia; oxygen; reoxygenation}}, language = {{eng}}, number = {{8}}, pages = {{889--895}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Pædiatrica}}, title = {{Cerebral excitatory amino acids and Na+,K+-ATPase activity during resuscitation of severely hypoxic newborn piglets}}, url = {{http://dx.doi.org/10.1111/j.1651-2227.1998.tb01557.x}}, doi = {{10.1111/j.1651-2227.1998.tb01557.x}}, volume = {{87}}, year = {{1998}}, }