Photobleaching-Insensitive Fluorescence Diagnostics in Skin and Brain Tissue
(2011) In IEEE Photonics Journal 3(3). p.407-421- Abstract
- In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-based fluorescence spectroscopy system. We have developed an effective method for the parameterization of sequences of bleaching spectra. We analyze convergence and decay rates with respect to initial conditions and excitation irradiance. We also discuss the consequences and the potential for bleaching-insensitive measurements and their... (More)
- In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-based fluorescence spectroscopy system. We have developed an effective method for the parameterization of sequences of bleaching spectra. We analyze convergence and decay rates with respect to initial conditions and excitation irradiance. We also discuss the consequences and the potential for bleaching-insensitive measurements and their applicability in a few examples from in vivo open brain surgery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1987844
- author
- Brydegaard, Mikkel LU ; Haj-Hosseini, N. ; Wardell, K. and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fluorescence-guided resection, FGR, 5-ALA, PpIX, protoporphyrin, photobleaching, laser-induced fluorescence spectroscopy, LIF, optical, diagnostics, tissue optics, skin, brain, dynamic models, system, identification, state space models
- in
- IEEE Photonics Journal
- volume
- 3
- issue
- 3
- pages
- 407 - 421
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- external identifiers
-
- wos:000290429400001
- scopus:79955871701
- ISSN
- 1943-0655
- DOI
- 10.1109/JPHOT.2011.2141656
- language
- English
- LU publication?
- yes
- id
- 3ffbaa10-9a9c-450c-bc40-a65ee2f389bd (old id 1987844)
- date added to LUP
- 2016-04-01 14:32:26
- date last changed
- 2022-01-28 01:08:29
@article{3ffbaa10-9a9c-450c-bc40-a65ee2f389bd, abstract = {{In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-based fluorescence spectroscopy system. We have developed an effective method for the parameterization of sequences of bleaching spectra. We analyze convergence and decay rates with respect to initial conditions and excitation irradiance. We also discuss the consequences and the potential for bleaching-insensitive measurements and their applicability in a few examples from in vivo open brain surgery.}}, author = {{Brydegaard, Mikkel and Haj-Hosseini, N. and Wardell, K. and Andersson-Engels, Stefan}}, issn = {{1943-0655}}, keywords = {{Fluorescence-guided resection; FGR; 5-ALA; PpIX; protoporphyrin; photobleaching; laser-induced fluorescence spectroscopy; LIF; optical; diagnostics; tissue optics; skin; brain; dynamic models; system; identification; state space models}}, language = {{eng}}, number = {{3}}, pages = {{407--421}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, series = {{IEEE Photonics Journal}}, title = {{Photobleaching-Insensitive Fluorescence Diagnostics in Skin and Brain Tissue}}, url = {{https://lup.lub.lu.se/search/files/4029977/2368942.pdf}}, doi = {{10.1109/JPHOT.2011.2141656}}, volume = {{3}}, year = {{2011}}, }