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Identification and Characterization of New Mechanisms in Vascular Estrogen Signalling.

Holm, Anders LU and Nilsson, Bengt-Olof LU (2013) In Basic & Clinical Pharmacology & Toxicology2004-01-01+01:002014-01-01+01:00 113(5). p.287-293
Abstract
Estrogen exerts vasculoprotective effects in different experimental settings through inhibition of vascular smooth muscle cell proliferation, stimulation of nitric oxide production and attenuation of inflammation. Although these estrogen-evoked beneficial effects have been attributed to estrogen receptor α (ERα), also ERβ and the novel ER GPR30/GPER1 probably play significant roles in vascular estrogen signalling. Estrogen-evoked vasculoprotective effects are well documented in various experimental models, but the underlying mechanisms are still incompletely understood. The age hypothesis represents an interesting and promising model to explain the discrepancy between experimental data showing beneficial vascular effects of estrogen... (More)
Estrogen exerts vasculoprotective effects in different experimental settings through inhibition of vascular smooth muscle cell proliferation, stimulation of nitric oxide production and attenuation of inflammation. Although these estrogen-evoked beneficial effects have been attributed to estrogen receptor α (ERα), also ERβ and the novel ER GPR30/GPER1 probably play significant roles in vascular estrogen signalling. Estrogen-evoked vasculoprotective effects are well documented in various experimental models, but the underlying mechanisms are still incompletely understood. The age hypothesis represents an interesting and promising model to explain the discrepancy between experimental data showing beneficial vascular effects of estrogen treatment and the clinical findings on hormone replacement therapy obtained in big epidemiology surveys, where no protective effect from supplementation with estrogen is observed. Identification of novel ERs expressed also in the vascular system offers exciting opportunities for the future to find and characterize the mechanisms behind estrogen-evoked beneficial effects in vascular health and disease. Importantly, some vascular effects of pharmacological concentrations of estrogen are ER-independent, suggesting that estrogen besides its specific effects through ERα, ERβ and GPR30 also affects vascular function via ER-independent mechanisms probably reflecting interaction of the hydrophobic estrogen molecule with cell membrane properties. In this MiniReview, we focus on the importance of these different vascular ER subtypes in health and disease. This article is protected by copyright. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Basic & Clinical Pharmacology & Toxicology2004-01-01+01:002014-01-01+01:00
volume
113
issue
5
pages
287 - 293
publisher
Wiley-Blackwell
external identifiers
  • wos:000325465200001
  • pmid:23953673
  • scopus:84885483209
ISSN
1742-7843
DOI
10.1111/bcpt.12118
language
English
LU publication?
yes
id
ea2406e4-bad9-4b41-9181-e9c76ef7c9fe (old id 4005571)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23953673?dopt=Abstract
date added to LUP
2013-09-04 18:08:47
date last changed
2019-07-02 01:31:18
@article{ea2406e4-bad9-4b41-9181-e9c76ef7c9fe,
  abstract     = {Estrogen exerts vasculoprotective effects in different experimental settings through inhibition of vascular smooth muscle cell proliferation, stimulation of nitric oxide production and attenuation of inflammation. Although these estrogen-evoked beneficial effects have been attributed to estrogen receptor α (ERα), also ERβ and the novel ER GPR30/GPER1 probably play significant roles in vascular estrogen signalling. Estrogen-evoked vasculoprotective effects are well documented in various experimental models, but the underlying mechanisms are still incompletely understood. The age hypothesis represents an interesting and promising model to explain the discrepancy between experimental data showing beneficial vascular effects of estrogen treatment and the clinical findings on hormone replacement therapy obtained in big epidemiology surveys, where no protective effect from supplementation with estrogen is observed. Identification of novel ERs expressed also in the vascular system offers exciting opportunities for the future to find and characterize the mechanisms behind estrogen-evoked beneficial effects in vascular health and disease. Importantly, some vascular effects of pharmacological concentrations of estrogen are ER-independent, suggesting that estrogen besides its specific effects through ERα, ERβ and GPR30 also affects vascular function via ER-independent mechanisms probably reflecting interaction of the hydrophobic estrogen molecule with cell membrane properties. In this MiniReview, we focus on the importance of these different vascular ER subtypes in health and disease. This article is protected by copyright. All rights reserved.},
  author       = {Holm, Anders and Nilsson, Bengt-Olof},
  issn         = {1742-7843},
  language     = {eng},
  number       = {5},
  pages        = {287--293},
  publisher    = {Wiley-Blackwell},
  series       = {Basic & Clinical Pharmacology & Toxicology2004-01-01+01:002014-01-01+01:00},
  title        = {Identification and Characterization of New Mechanisms in Vascular Estrogen Signalling.},
  url          = {http://dx.doi.org/10.1111/bcpt.12118},
  volume       = {113},
  year         = {2013},
}