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Prospective study of merkel cell polyomavirus and risk of merkel cell carcinoma.

Faust, Helena LU ; Andersson, Kristin LU ; Ekström, Johanna LU ; Hortlund, Maria LU ; Robsahm, Trude Eid and Dillner, Joakim LU (2014) In International Journal of Cancer 134(4). p.844-848
Abstract
Merkel cell carcinoma (MCC) is a rare type of skin cancer that has a characteristically increased incidence among immunosuppressed subjects. The DNA of Merkel cell polyomavirus (MCV) is regularly found in most MCC tumors. We investigated whether Merkel cell polyomavirus (MCV) infection increases the risk for future Merkel cell carcinoma (MCC). Two large biobank cohorts (Southern Sweden Microbiology Biobank and the Janus Biobank), containing samples from 856,000 healthy donors, were linked to the Cancer Registries in Sweden and Norway to identify cases of MCC occurring up to 30 years after donation of a serum sample. For each of the 22 cases (9 males and 13 females), four matched controls were included. The serum samples were analysed with... (More)
Merkel cell carcinoma (MCC) is a rare type of skin cancer that has a characteristically increased incidence among immunosuppressed subjects. The DNA of Merkel cell polyomavirus (MCV) is regularly found in most MCC tumors. We investigated whether Merkel cell polyomavirus (MCV) infection increases the risk for future Merkel cell carcinoma (MCC). Two large biobank cohorts (Southern Sweden Microbiology Biobank and the Janus Biobank), containing samples from 856,000 healthy donors, were linked to the Cancer Registries in Sweden and Norway to identify cases of MCC occurring up to 30 years after donation of a serum sample. For each of the 22 cases (9 males and 13 females), four matched controls were included. The serum samples were analysed with an MCV neutralization assay and for IgG antibodies to MCV pseudovirions, using JC polyomavirus and cutaneous Human papillomaviruses as control antigens. An increased risk for future MCC was associated both with high levels of MCV antibodies (OR 4.4, 95% CI 1.3-17.4) and with MCV neutralizing activity (OR 5.3, 95% CI 1.3-32.3). In males, MCV seropositivity was not associated to MCC risk, whereas the risk was strongly increased in females, both for high levels of MCV antibodies (OR 7.0, 95% CI 1.6-42.8) and for MCV neutralizing activity (OR 14.3, 95% CI 1.7-677). In conclusion, we found prospective evidence that MCV infection is associated with an increased risk for future MCC, in particular among females. © 2013 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
134
issue
4
pages
844 - 848
publisher
John Wiley & Sons
external identifiers
  • wos:000327889700012
  • pmid:23922031
  • scopus:84890126116
ISSN
0020-7136
DOI
10.1002/ijc.28419
language
English
LU publication?
yes
id
c47ed4ad-ce0b-4441-b7b5-1dd0274c58fc (old id 4006081)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23922031?dopt=Abstract
date added to LUP
2013-09-03 14:27:04
date last changed
2017-05-14 03:24:03
@article{c47ed4ad-ce0b-4441-b7b5-1dd0274c58fc,
  abstract     = {Merkel cell carcinoma (MCC) is a rare type of skin cancer that has a characteristically increased incidence among immunosuppressed subjects. The DNA of Merkel cell polyomavirus (MCV) is regularly found in most MCC tumors. We investigated whether Merkel cell polyomavirus (MCV) infection increases the risk for future Merkel cell carcinoma (MCC). Two large biobank cohorts (Southern Sweden Microbiology Biobank and the Janus Biobank), containing samples from 856,000 healthy donors, were linked to the Cancer Registries in Sweden and Norway to identify cases of MCC occurring up to 30 years after donation of a serum sample. For each of the 22 cases (9 males and 13 females), four matched controls were included. The serum samples were analysed with an MCV neutralization assay and for IgG antibodies to MCV pseudovirions, using JC polyomavirus and cutaneous Human papillomaviruses as control antigens. An increased risk for future MCC was associated both with high levels of MCV antibodies (OR 4.4, 95% CI 1.3-17.4) and with MCV neutralizing activity (OR 5.3, 95% CI 1.3-32.3). In males, MCV seropositivity was not associated to MCC risk, whereas the risk was strongly increased in females, both for high levels of MCV antibodies (OR 7.0, 95% CI 1.6-42.8) and for MCV neutralizing activity (OR 14.3, 95% CI 1.7-677). In conclusion, we found prospective evidence that MCV infection is associated with an increased risk for future MCC, in particular among females. © 2013 Wiley Periodicals, Inc.},
  author       = {Faust, Helena and Andersson, Kristin and Ekström, Johanna and Hortlund, Maria and Robsahm, Trude Eid and Dillner, Joakim},
  issn         = {0020-7136},
  language     = {eng},
  number       = {4},
  pages        = {844--848},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Prospective study of merkel cell polyomavirus and risk of merkel cell carcinoma.},
  url          = {http://dx.doi.org/10.1002/ijc.28419},
  volume       = {134},
  year         = {2014},
}