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Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

Schaar, Viveka LU ; Uddbäck, Ida ; Nordström, Therése LU and Riesbeck, Kristian LU orcid (2014) In Journal of Antimicrobial Chemotherapy 69(1). p.117-120
Abstract
Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Antimicrobial Chemotherapy
volume
69
issue
1
pages
117 - 120
publisher
Oxford University Press
external identifiers
  • wos:000328425400018
  • pmid:23912886
  • scopus:84890407646
ISSN
1460-2091
DOI
10.1093/jac/dkt307
language
English
LU publication?
yes
id
8cb8ac7f-c2bd-4059-a0b6-c1974cef8b5b (old id 4006182)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23912886?dopt=Abstract
date added to LUP
2016-04-01 10:38:20
date last changed
2022-03-27 18:07:18
@article{8cb8ac7f-c2bd-4059-a0b6-c1974cef8b5b,
  abstract     = {{Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.}},
  author       = {{Schaar, Viveka and Uddbäck, Ida and Nordström, Therése and Riesbeck, Kristian}},
  issn         = {{1460-2091}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{117--120}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Antimicrobial Chemotherapy}},
  title        = {{Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.}},
  url          = {{https://lup.lub.lu.se/search/files/2015664/4402390.pdf}},
  doi          = {{10.1093/jac/dkt307}},
  volume       = {{69}},
  year         = {{2014}},
}