Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.
(2014) In Journal of Antimicrobial Chemotherapy 69(1). p.117-120- Abstract
- Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4006182
- author
- Schaar, Viveka LU ; Uddbäck, Ida ; Nordström, Therése LU and Riesbeck, Kristian LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Antimicrobial Chemotherapy
- volume
- 69
- issue
- 1
- pages
- 117 - 120
- publisher
- Oxford University Press
- external identifiers
-
- wos:000328425400018
- pmid:23912886
- scopus:84890407646
- ISSN
- 1460-2091
- DOI
- 10.1093/jac/dkt307
- language
- English
- LU publication?
- yes
- id
- 8cb8ac7f-c2bd-4059-a0b6-c1974cef8b5b (old id 4006182)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23912886?dopt=Abstract
- date added to LUP
- 2016-04-01 10:38:20
- date last changed
- 2022-03-27 18:07:18
@article{8cb8ac7f-c2bd-4059-a0b6-c1974cef8b5b, abstract = {{Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.}}, author = {{Schaar, Viveka and Uddbäck, Ida and Nordström, Therése and Riesbeck, Kristian}}, issn = {{1460-2091}}, language = {{eng}}, number = {{1}}, pages = {{117--120}}, publisher = {{Oxford University Press}}, series = {{Journal of Antimicrobial Chemotherapy}}, title = {{Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.}}, url = {{https://lup.lub.lu.se/search/files/2015664/4402390.pdf}}, doi = {{10.1093/jac/dkt307}}, volume = {{69}}, year = {{2014}}, }