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Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

Schaar, Viveka LU ; Uddbäck, Ida; Nordström, Therése LU and Riesbeck, Kristian LU (2014) In Journal of Antimicrobial Chemotherapy 69(1). p.117-120
Abstract
Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Antimicrobial Chemotherapy
volume
69
issue
1
pages
117 - 120
publisher
Oxford University Press
external identifiers
  • wos:000328425400018
  • pmid:23912886
  • scopus:84890407646
ISSN
1460-2091
DOI
10.1093/jac/dkt307
language
English
LU publication?
yes
id
8cb8ac7f-c2bd-4059-a0b6-c1974cef8b5b (old id 4006182)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23912886?dopt=Abstract
date added to LUP
2013-09-03 14:02:08
date last changed
2017-11-12 03:10:16
@article{8cb8ac7f-c2bd-4059-a0b6-c1974cef8b5b,
  abstract     = {Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.},
  author       = {Schaar, Viveka and Uddbäck, Ida and Nordström, Therése and Riesbeck, Kristian},
  issn         = {1460-2091},
  language     = {eng},
  number       = {1},
  pages        = {117--120},
  publisher    = {Oxford University Press},
  series       = {Journal of Antimicrobial Chemotherapy},
  title        = {Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.},
  url          = {http://dx.doi.org/10.1093/jac/dkt307},
  volume       = {69},
  year         = {2014},
}