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The heritable determinants of cartilage oligomeric matrix protein

Williams, Frances M. K. ; Andrew, Toby ; Saxne, Tore LU ; Heinegård, Dick LU ; Spector, Tim D. and MacGregor, Alex J. (2006) In Arthritis and Rheumatism 54(7). p.2147-2151
Abstract
Objective. Cartilage oligomeric matrix protein (COMP) is a cartilage matrix macromolecule. The protein is detectable in serum and has been investigated as a biomarker of osteoarthritis (OA). An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear. The aim of this study was to determine whether genetic factors influence serum levels of COMP. Methods. A classic twin study was conducted using COMP levels in serum obtained from healthy female twin volunteers. COMP levels were determined by an inhibition enzyme-linked immunosorbent assay method. The heritability of COMP was determined by comparing correlation among 160 monozygotic and 349 dizygotic twin pairs. Data on potential... (More)
Objective. Cartilage oligomeric matrix protein (COMP) is a cartilage matrix macromolecule. The protein is detectable in serum and has been investigated as a biomarker of osteoarthritis (OA). An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear. The aim of this study was to determine whether genetic factors influence serum levels of COMP. Methods. A classic twin study was conducted using COMP levels in serum obtained from healthy female twin volunteers. COMP levels were determined by an inhibition enzyme-linked immunosorbent assay method. The heritability of COMP was determined by comparing correlation among 160 monozygotic and 349 dizygotic twin pairs. Data on potential confounding factors, including age, body mass index, and the presence of OA as assessed by hand, hip, and knee radiographs, were included in the analysis. Results. Serum levels of COMP showed a correlation of 0.72 (95% confidence interval [95% CI] 0.650.80) among monozygotic twin pairs and 0.47 (95% CI 0.39-0.55) in dizygotic pairs. This equated to an estimated heritability for COMP of 40% (95% CI 20-60%). Although age and body mass index were found to be significantly associated with COMP in regression analysis, taking the effects of these factors into account did not influence the estimate of heritability. Conclusion. This study showed that heritable factors influence serum levels of the cartilage matrix biomarker COMP. Together with other published data, the results suggest that genetic factors operate at an early stage in the etiologic pathways that influence the development of radiographically discernible OA. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis and Rheumatism
volume
54
issue
7
pages
2147 - 2151
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:16802351
  • wos:000238939000012
  • scopus:33745883565
ISSN
1529-0131
DOI
10.1002/art.21931
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Connective Tissue Biology (013230151)
id
2a608c01-0c7b-49ff-a093-12134604aecc (old id 402401)
date added to LUP
2016-04-01 12:29:33
date last changed
2020-03-11 02:58:46
@article{2a608c01-0c7b-49ff-a093-12134604aecc,
  abstract     = {Objective. Cartilage oligomeric matrix protein (COMP) is a cartilage matrix macromolecule. The protein is detectable in serum and has been investigated as a biomarker of osteoarthritis (OA). An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear. The aim of this study was to determine whether genetic factors influence serum levels of COMP. Methods. A classic twin study was conducted using COMP levels in serum obtained from healthy female twin volunteers. COMP levels were determined by an inhibition enzyme-linked immunosorbent assay method. The heritability of COMP was determined by comparing correlation among 160 monozygotic and 349 dizygotic twin pairs. Data on potential confounding factors, including age, body mass index, and the presence of OA as assessed by hand, hip, and knee radiographs, were included in the analysis. Results. Serum levels of COMP showed a correlation of 0.72 (95% confidence interval [95% CI] 0.650.80) among monozygotic twin pairs and 0.47 (95% CI 0.39-0.55) in dizygotic pairs. This equated to an estimated heritability for COMP of 40% (95% CI 20-60%). Although age and body mass index were found to be significantly associated with COMP in regression analysis, taking the effects of these factors into account did not influence the estimate of heritability. Conclusion. This study showed that heritable factors influence serum levels of the cartilage matrix biomarker COMP. Together with other published data, the results suggest that genetic factors operate at an early stage in the etiologic pathways that influence the development of radiographically discernible OA.},
  author       = {Williams, Frances M. K. and Andrew, Toby and Saxne, Tore and Heinegård, Dick and Spector, Tim D. and MacGregor, Alex J.},
  issn         = {1529-0131},
  language     = {eng},
  number       = {7},
  pages        = {2147--2151},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Arthritis and Rheumatism},
  title        = {The heritable determinants of cartilage oligomeric matrix protein},
  url          = {http://dx.doi.org/10.1002/art.21931},
  doi          = {10.1002/art.21931},
  volume       = {54},
  year         = {2006},
}