Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization

Vaccaro, Mauro LU ; Accardo, Antonella ; Tesauro, Diego ; Mangiapia, Gaetano ; Löf, David LU ; Schillén, Karin LU orcid ; Söderman, Olle LU ; Morelli, Giancarlo and Paduano, Luigi (2006) In Langmuir 22(15). p.6635-6643
Abstract
In this paper, we present the development of a new potential blood pool contrast agent for magnetic resonance imaging applications (MRA/MRI) based on gadolinium complexes containing amphiphilic supramolecular aggregates. A novel amphiphilic unimer, containing the DTPAGlu chelating agent covalently bound to two C18 alkylic chains, has been synthesized. DTPAGlu is a well-known chelating agent for a wide number of ions such as the paramagnetic metal ion Gd3+ used as contrast agent in MRA/MRI. The wide aggregation behavior of this surfactant, as free base or as gadolinium complex, has been studied and compared by means of dynamic light scattering, small-angle neutron scattering and cryogenic transmission electron microscopy techniques. Near... (More)
In this paper, we present the development of a new potential blood pool contrast agent for magnetic resonance imaging applications (MRA/MRI) based on gadolinium complexes containing amphiphilic supramolecular aggregates. A novel amphiphilic unimer, containing the DTPAGlu chelating agent covalently bound to two C18 alkylic chains, has been synthesized. DTPAGlu is a well-known chelating agent for a wide number of ions such as the paramagnetic metal ion Gd3+ used as contrast agent in MRA/MRI. The wide aggregation behavior of this surfactant, as free base or as gadolinium complex, has been studied and compared by means of dynamic light scattering, small-angle neutron scattering and cryogenic transmission electron microscopy techniques. Near neutral pH in both cases, the dominant aggregates are micelles. The high negative actual charge of the surfactant headgroup causes a strong headgroups repulsion, promoting the formation of large and high curvature aggregates. By decreasing pH and less markedly increasing the ionic strength, we observe a micelle-to-vesicle transition driven by a decreased electrostatic repulsion. A straightforward switch between different aggregation states can be particularly useful in the development of pH-responsive MRA/MRI contrast agents. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
22
issue
15
pages
6635 - 6643
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000238926000026
  • scopus:33746615073
  • pmid:16831007
ISSN
0743-7463
DOI
10.1021/la053500k
language
English
LU publication?
yes
id
d2a7b70d-cf71-4188-bd1b-d5aeef801d37 (old id 403982)
date added to LUP
2016-04-01 11:53:32
date last changed
2022-01-26 19:48:16
@article{d2a7b70d-cf71-4188-bd1b-d5aeef801d37,
  abstract     = {{In this paper, we present the development of a new potential blood pool contrast agent for magnetic resonance imaging applications (MRA/MRI) based on gadolinium complexes containing amphiphilic supramolecular aggregates. A novel amphiphilic unimer, containing the DTPAGlu chelating agent covalently bound to two C18 alkylic chains, has been synthesized. DTPAGlu is a well-known chelating agent for a wide number of ions such as the paramagnetic metal ion Gd3+ used as contrast agent in MRA/MRI. The wide aggregation behavior of this surfactant, as free base or as gadolinium complex, has been studied and compared by means of dynamic light scattering, small-angle neutron scattering and cryogenic transmission electron microscopy techniques. Near neutral pH in both cases, the dominant aggregates are micelles. The high negative actual charge of the surfactant headgroup causes a strong headgroups repulsion, promoting the formation of large and high curvature aggregates. By decreasing pH and less markedly increasing the ionic strength, we observe a micelle-to-vesicle transition driven by a decreased electrostatic repulsion. A straightforward switch between different aggregation states can be particularly useful in the development of pH-responsive MRA/MRI contrast agents.}},
  author       = {{Vaccaro, Mauro and Accardo, Antonella and Tesauro, Diego and Mangiapia, Gaetano and Löf, David and Schillén, Karin and Söderman, Olle and Morelli, Giancarlo and Paduano, Luigi}},
  issn         = {{0743-7463}},
  language     = {{eng}},
  number       = {{15}},
  pages        = {{6635--6643}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Langmuir}},
  title        = {{Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization}},
  url          = {{http://dx.doi.org/10.1021/la053500k}},
  doi          = {{10.1021/la053500k}},
  volume       = {{22}},
  year         = {{2006}},
}