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Tumour marking properties of different haematoporphyrins and tetrasulfonated phthalocyanine - A comparison

Andersson-Engels, Stefan LU ; Ankerst, J LU orcid ; Johansson, Jonas LU ; Svanberg, Katarina LU and Svanberg, Sune LU (1989) In Lasers in Medical Science 4(2). p.115-123
Abstract
Several photosensitizers were screened for their tumour-marking ability using laserinduced fluorescence in Wistar/Furth rats bearing subcutaneous adenocarcinomas inoculated in muscle. Of the studied photosensitizers, dihaematoporphyrin ether appeared to exhibit the best tumour-demarcation properties. Polyhaematoporphyrin ester and tetrasulfonated phthalocyanine were almost as good although the fluorescence yield was much lower. Monomeric haematoporphyrin also showed some tumour-marking qualities. By forming fluorescence intensity ratios, information from both the blue and the red spectral regions were used to provide the highest tumour-to-muscle contrast. Two excitation wavelengths were used, of which 337 nm rather than 405 nm excitation... (More)
Several photosensitizers were screened for their tumour-marking ability using laserinduced fluorescence in Wistar/Furth rats bearing subcutaneous adenocarcinomas inoculated in muscle. Of the studied photosensitizers, dihaematoporphyrin ether appeared to exhibit the best tumour-demarcation properties. Polyhaematoporphyrin ester and tetrasulfonated phthalocyanine were almost as good although the fluorescence yield was much lower. Monomeric haematoporphyrin also showed some tumour-marking qualities. By forming fluorescence intensity ratios, information from both the blue and the red spectral regions were used to provide the highest tumour-to-muscle contrast. Two excitation wavelengths were used, of which 337 nm rather than 405 nm excitation light seemed to yield a better tumour demarcation, due to a greater difference in the superimposing autofluorescence between tumour and surrounding tissue. The study included measurements on many inner organs in an attempt to gain a better understanding of the interaction between the drugs and various kinds of tissue. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Medicine
in
Lasers in Medical Science
volume
4
issue
2
pages
115 - 123
publisher
Springer Science and Business Media B.V.
external identifiers
  • scopus:0024357269
ISSN
0268-8921
DOI
10.1007/BF02032608
language
English
LU publication?
yes
id
403dd5d0-4f2b-4060-97ed-cd1b3305f5cf (old id 2257245)
date added to LUP
2016-04-01 16:46:33
date last changed
2025-10-14 10:45:55
@article{403dd5d0-4f2b-4060-97ed-cd1b3305f5cf,
  abstract     = {{Several photosensitizers were screened for their tumour-marking ability using laserinduced fluorescence in Wistar/Furth rats bearing subcutaneous adenocarcinomas inoculated in muscle. Of the studied photosensitizers, dihaematoporphyrin ether appeared to exhibit the best tumour-demarcation properties. Polyhaematoporphyrin ester and tetrasulfonated phthalocyanine were almost as good although the fluorescence yield was much lower. Monomeric haematoporphyrin also showed some tumour-marking qualities. By forming fluorescence intensity ratios, information from both the blue and the red spectral regions were used to provide the highest tumour-to-muscle contrast. Two excitation wavelengths were used, of which 337 nm rather than 405 nm excitation light seemed to yield a better tumour demarcation, due to a greater difference in the superimposing autofluorescence between tumour and surrounding tissue. The study included measurements on many inner organs in an attempt to gain a better understanding of the interaction between the drugs and various kinds of tissue.}},
  author       = {{Andersson-Engels, Stefan and Ankerst, J and Johansson, Jonas and Svanberg, Katarina and Svanberg, Sune}},
  issn         = {{0268-8921}},
  keywords     = {{Medicine}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{115--123}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{Lasers in Medical Science}},
  title        = {{Tumour marking properties of different haematoporphyrins and tetrasulfonated phthalocyanine - A comparison}},
  url          = {{https://lup.lub.lu.se/search/files/4776925/2365650.pdf}},
  doi          = {{10.1007/BF02032608}},
  volume       = {{4}},
  year         = {{1989}},
}