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On neural plasticity, new neurons and the postischemic milieu: An integrated view on experimental rehabilitation

Komitova, Mila ; Johansson, Barbro and Eriksson, Peter S. (2006) In Experimental Neurology 199(1). p.42-55
Abstract
This review discusses actual and potential contributors to functional improvement after stroke injuries. Topics that will be covered are neuronal re-organization and sprouting, neural stem/progenitor cell,activation and neuronal replacement, as well as the neuronal milieu defined by glia, inflammatory cells and blood vessel supply. It is well established that different types of neuronal plasticity ultimately lead to post-stroke recovery. However, an untapped potential which only recently has started to be extensively explored is neuronal replacement through endogenous or exogenous resources. Major experimental efforts are needed to achieve progress in this burgeoning area. The review stresses the importance of applying neurodevelopmental... (More)
This review discusses actual and potential contributors to functional improvement after stroke injuries. Topics that will be covered are neuronal re-organization and sprouting, neural stem/progenitor cell,activation and neuronal replacement, as well as the neuronal milieu defined by glia, inflammatory cells and blood vessel supply. It is well established that different types of neuronal plasticity ultimately lead to post-stroke recovery. However, an untapped potential which only recently has started to be extensively explored is neuronal replacement through endogenous or exogenous resources. Major experimental efforts are needed to achieve progress in this burgeoning area. The review stresses the importance of applying neurodevelopmental principles as well as performing a characterization of the role of the postischemic milieu when studying adult brain neural stem/progenitor cells. Integrated and multifaceted experimentation, incorporating actual and possible poststroke function modulators, will be necessary in order to determine future strategies that will ultimately enable considerable progress in the field of neurorehabilitation. (c) 2006 Elsevier Inc. All rights reserved. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
sprouting, gliogenesis, neurogenesis, neural stem cells, neural plasticity, rehabilitation, recovery, stroke, brain ischemia
in
Experimental Neurology
volume
199
issue
1
pages
42 - 55
publisher
Elsevier
external identifiers
  • pmid:16631168
  • wos:000238800700009
  • scopus:33745212184
ISSN
0014-4886
DOI
10.1016/j.expneurol.2006.03.010
language
English
LU publication?
yes
id
f813378a-ab39-427d-ba64-c958f7bb8a8e (old id 404161)
date added to LUP
2016-04-01 11:42:29
date last changed
2021-02-17 08:12:50
@article{f813378a-ab39-427d-ba64-c958f7bb8a8e,
  abstract     = {This review discusses actual and potential contributors to functional improvement after stroke injuries. Topics that will be covered are neuronal re-organization and sprouting, neural stem/progenitor cell,activation and neuronal replacement, as well as the neuronal milieu defined by glia, inflammatory cells and blood vessel supply. It is well established that different types of neuronal plasticity ultimately lead to post-stroke recovery. However, an untapped potential which only recently has started to be extensively explored is neuronal replacement through endogenous or exogenous resources. Major experimental efforts are needed to achieve progress in this burgeoning area. The review stresses the importance of applying neurodevelopmental principles as well as performing a characterization of the role of the postischemic milieu when studying adult brain neural stem/progenitor cells. Integrated and multifaceted experimentation, incorporating actual and possible poststroke function modulators, will be necessary in order to determine future strategies that will ultimately enable considerable progress in the field of neurorehabilitation. (c) 2006 Elsevier Inc. All rights reserved.},
  author       = {Komitova, Mila and Johansson, Barbro and Eriksson, Peter S.},
  issn         = {0014-4886},
  language     = {eng},
  number       = {1},
  pages        = {42--55},
  publisher    = {Elsevier},
  series       = {Experimental Neurology},
  title        = {On neural plasticity, new neurons and the postischemic milieu: An integrated view on experimental rehabilitation},
  url          = {http://dx.doi.org/10.1016/j.expneurol.2006.03.010},
  doi          = {10.1016/j.expneurol.2006.03.010},
  volume       = {199},
  year         = {2006},
}