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Ultrasound screening for fetal anomalies in Southern Sweden: a population-based study

Nikkilä, Annamari LU ; Rydhstrom, H ; Källén, Bengt LU and Jorgensen, C (2006) In Acta Obstetricia et Gynecologica Scandinavica 85(6). p.688-693
Abstract
Background. The accuracy of ultrasound in the diagnosis of congenital malformations has been the subject of many studies. Most of these are hospital-based studies over a limited period of years presenting high detection rates and also relatively high incidence of major malformations. We present here a large population-based study over a long period of years. Methods. The prenatal diagnoses are compared with the diagnoses of the newborns and aborted fetuses, including autopsy results. The detection rate of some common structural malformations is studied. Results. The overall detection rate of malformations in our study was 28.4%. We noticed an improved detection rate of heart defects and cleft lip during the study period. The prevalence of... (More)
Background. The accuracy of ultrasound in the diagnosis of congenital malformations has been the subject of many studies. Most of these are hospital-based studies over a limited period of years presenting high detection rates and also relatively high incidence of major malformations. We present here a large population-based study over a long period of years. Methods. The prenatal diagnoses are compared with the diagnoses of the newborns and aborted fetuses, including autopsy results. The detection rate of some common structural malformations is studied. Results. The overall detection rate of malformations in our study was 28.4%. We noticed an improved detection rate of heart defects and cleft lip during the study period. The prevalence of malformations in the population was 2.6%. The false positive diagnoses were few, 54 cases, and mainly of a mild nature. Conclusions. Ultrasound screening of fetal malformations in our population has a low false positive rate and even though the overall sensitivity is low, 28.4%, the detection rate for many common structural malformations is relatively good. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
congenital malformations, detection rate, screening, ultrasound
in
Acta Obstetricia et Gynecologica Scandinavica
volume
85
issue
6
pages
688 - 693
publisher
Wiley-Blackwell
external identifiers
  • pmid:16752260
  • wos:000238188100008
  • scopus:33745714428
ISSN
1600-0412
DOI
10.1080/00016340600676474
language
English
LU publication?
yes
id
7161eaaf-bb45-4e88-acf8-4c14bbf817f1 (old id 406927)
date added to LUP
2016-04-01 17:13:41
date last changed
2021-02-17 05:01:16
@article{7161eaaf-bb45-4e88-acf8-4c14bbf817f1,
  abstract     = {Background. The accuracy of ultrasound in the diagnosis of congenital malformations has been the subject of many studies. Most of these are hospital-based studies over a limited period of years presenting high detection rates and also relatively high incidence of major malformations. We present here a large population-based study over a long period of years. Methods. The prenatal diagnoses are compared with the diagnoses of the newborns and aborted fetuses, including autopsy results. The detection rate of some common structural malformations is studied. Results. The overall detection rate of malformations in our study was 28.4%. We noticed an improved detection rate of heart defects and cleft lip during the study period. The prevalence of malformations in the population was 2.6%. The false positive diagnoses were few, 54 cases, and mainly of a mild nature. Conclusions. Ultrasound screening of fetal malformations in our population has a low false positive rate and even though the overall sensitivity is low, 28.4%, the detection rate for many common structural malformations is relatively good.},
  author       = {Nikkilä, Annamari and Rydhstrom, H and Källén, Bengt and Jorgensen, C},
  issn         = {1600-0412},
  language     = {eng},
  number       = {6},
  pages        = {688--693},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Ultrasound screening for fetal anomalies in Southern Sweden: a population-based study},
  url          = {http://dx.doi.org/10.1080/00016340600676474},
  doi          = {10.1080/00016340600676474},
  volume       = {85},
  year         = {2006},
}