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A European multicentre survey of impulse control behaviours in Parkinson's disease patients treated with short- and long-acting dopamine agonists

Rizos, A. ; Sauerbier, A. ; Antonini, A. ; Weintraub, D. ; Martinez-Martin, P. ; Kessel, B. ; Henriksen, T. ; Falup-Pecurariu, C. ; Silverdale, M. and Durner, G. , et al. (2016) In European Journal of Neurology 23(8). p.1255-1261
Abstract

Background and purpose: Impulse control disorders (ICDs) in Parkinson's disease (PD) are associated primarily with dopamine agonist (DA) use. Comparative surveys of clinical occurrence of impulse control behaviours on longer acting/transdermal DA therapy across age ranges are lacking. The aim of this study was to assess the occurrence of ICDs in PD patients across several European centres treated with short- or long-acting [ropinirole (ROP); pramipexole (PPX)] and transdermal [rotigotine skin patch (RTG)] DAs, based on clinical survey as part of routine clinical care. Methods: A survey based on medical records and clinical interviews of patients initiating or initiated on DA treatment (both short- and long-acting, and transdermal)... (More)

Background and purpose: Impulse control disorders (ICDs) in Parkinson's disease (PD) are associated primarily with dopamine agonist (DA) use. Comparative surveys of clinical occurrence of impulse control behaviours on longer acting/transdermal DA therapy across age ranges are lacking. The aim of this study was to assess the occurrence of ICDs in PD patients across several European centres treated with short- or long-acting [ropinirole (ROP); pramipexole (PPX)] and transdermal [rotigotine skin patch (RTG)] DAs, based on clinical survey as part of routine clinical care. Methods: A survey based on medical records and clinical interviews of patients initiating or initiated on DA treatment (both short- and long-acting, and transdermal) across a broad range of disease stages and age groups was performed. Results: Four hundred and twenty-five cases were included [mean age 68.3 years (range 37-90), mean duration of disease 7.5 years (range 0-37)]. ICD frequencies (as assessed by clinical interview) were significantly lower with RTG (4.9%; P <0.05) compared with any other assessed DAs except for prolonged release PPX (PPX-PR). The rate of ICDs for PPX-PR (6.6%) was significantly lower than for immediate release PPX (PPX-IR) (19.0%; P <0.05). Discontinuation rates of DA therapy due to ICDs were low. Conclusion: Our data suggest a relatively low rate of ICDs with long-acting or transdermal DAs, however these preliminary observational data need to be confirmed with prospective studies controlling for possible confounding factors.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dopamine agonists, Dopamine dysregulation syndrome, Impulse control behaviours/disorders, Parkinson's disease
in
European Journal of Neurology
volume
23
issue
8
pages
1255 - 1261
publisher
Wiley-Blackwell
external identifiers
  • pmid:27170229
  • wos:000380102300010
  • scopus:84978498958
ISSN
1351-5101
DOI
10.1111/ene.13034
language
English
LU publication?
yes
id
40e099e3-4c96-4422-a8c4-3a6bff21bcfa
date added to LUP
2016-06-21 15:13:24
date last changed
2022-12-06 04:59:55
@article{40e099e3-4c96-4422-a8c4-3a6bff21bcfa,
  abstract     = {{<p>Background and purpose: Impulse control disorders (ICDs) in Parkinson's disease (PD) are associated primarily with dopamine agonist (DA) use. Comparative surveys of clinical occurrence of impulse control behaviours on longer acting/transdermal DA therapy across age ranges are lacking. The aim of this study was to assess the occurrence of ICDs in PD patients across several European centres treated with short- or long-acting [ropinirole (ROP); pramipexole (PPX)] and transdermal [rotigotine skin patch (RTG)] DAs, based on clinical survey as part of routine clinical care. Methods: A survey based on medical records and clinical interviews of patients initiating or initiated on DA treatment (both short- and long-acting, and transdermal) across a broad range of disease stages and age groups was performed. Results: Four hundred and twenty-five cases were included [mean age 68.3 years (range 37-90), mean duration of disease 7.5 years (range 0-37)]. ICD frequencies (as assessed by clinical interview) were significantly lower with RTG (4.9%; P &lt;0.05) compared with any other assessed DAs except for prolonged release PPX (PPX-PR). The rate of ICDs for PPX-PR (6.6%) was significantly lower than for immediate release PPX (PPX-IR) (19.0%; P &lt;0.05). Discontinuation rates of DA therapy due to ICDs were low. Conclusion: Our data suggest a relatively low rate of ICDs with long-acting or transdermal DAs, however these preliminary observational data need to be confirmed with prospective studies controlling for possible confounding factors.</p>}},
  author       = {{Rizos, A. and Sauerbier, A. and Antonini, A. and Weintraub, D. and Martinez-Martin, P. and Kessel, B. and Henriksen, T. and Falup-Pecurariu, C. and Silverdale, M. and Durner, G. and Røkenes Karlsen, K. and Grilo, M. and Odin, P. and Chaudhuri, K. Ray}},
  issn         = {{1351-5101}},
  keywords     = {{Dopamine agonists; Dopamine dysregulation syndrome; Impulse control behaviours/disorders; Parkinson's disease}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{1255--1261}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Neurology}},
  title        = {{A European multicentre survey of impulse control behaviours in Parkinson's disease patients treated with short- and long-acting dopamine agonists}},
  url          = {{http://dx.doi.org/10.1111/ene.13034}},
  doi          = {{10.1111/ene.13034}},
  volume       = {{23}},
  year         = {{2016}},
}