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Adrenal incidentaloma - follow-up results from a Swedish prospective study

Bulow, B ; Jansson, S ; Juhlin, C ; Steen, L ; Thoren, M ; Wahrenberg, L ; Valdemarsson, Stig LU ; Wangberg, B and Ahrén, Bo LU (2006) In European Journal of Endocrinology 154(3). p.419-423
Abstract
Objectives: To examine the risk of developing adrenal carcinomas and clinically overt hypersecreting tumours during short-term follow-up in patients with adrenal incidentalomas. Design: 229 (98 males and 131 females) patients with adrenal incidentalomas were investigated in a prospective follow-up study (median time 25 months; range 3-108 months). The patients were registered between January 1996 and July 2001 and followed until December 2004. Twenty-seven Swedish hospitals contributed with follow-up results. Methods: Diagnostic procedures were undertaken according to a protocol including reinvestigation with Computed tomography scans after 3-6 months. 15-18 months and 27-30 months, as well as hormonal evaluation at baseline and after... (More)
Objectives: To examine the risk of developing adrenal carcinomas and clinically overt hypersecreting tumours during short-term follow-up in patients with adrenal incidentalomas. Design: 229 (98 males and 131 females) patients with adrenal incidentalomas were investigated in a prospective follow-up study (median time 25 months; range 3-108 months). The patients were registered between January 1996 and July 2001 and followed until December 2004. Twenty-seven Swedish hospitals contributed with follow-up results. Methods: Diagnostic procedures were undertaken according to a protocol including reinvestigation with Computed tomography scans after 3-6 months. 15-18 months and 27-30 months, as well as hormonal evaluation at baseline and after 27-30 months of follow-up. Operation was recommended when the incidentaloma size increased or if there was a suspicion of a hypersecreting tumour. Results: The median age at diagnosis of the 229 patients included in the follow-up study was 64 years (range 28-84 years) and the median size of the adrenal incidentalomas when discovered was 2.5 cm (range 1-8 cm). During the follow-up period, an increase in incidentaloma size of >= 0.5 cm was reported in 17 (7.4%) and of >= 1.0 cm was reported in 12 (5.2%,) of the 229 patients. A decrease in size was seen in 12 patients (5.2%). A hypersecreting tumour was found in 2%, of the hormonally investigated patients: Cushing's syndrome (n = 2) and phaeochromocytoma (n = 1). Eleven patients underwent adrenalectomy, but no cases of primary adrenal malignancy were observed. Conclusions: Patients with adrenal incidentaloma had a low risk of developing malignancy or hormonal hypersecretion during a short-term follow-up period. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Endocrinology
volume
154
issue
3
pages
419 - 423
publisher
Society of the European Journal of Endocrinology
external identifiers
  • wos:000237134500009
  • pmid:16498055
  • scopus:33645235494
ISSN
1479-683X
DOI
10.1530/eje.1.02110
language
English
LU publication?
yes
id
e4fada32-0866-4d28-86b3-1ed30d758986 (old id 410847)
date added to LUP
2016-04-01 12:12:32
date last changed
2021-09-08 02:06:34
@article{e4fada32-0866-4d28-86b3-1ed30d758986,
  abstract     = {Objectives: To examine the risk of developing adrenal carcinomas and clinically overt hypersecreting tumours during short-term follow-up in patients with adrenal incidentalomas. Design: 229 (98 males and 131 females) patients with adrenal incidentalomas were investigated in a prospective follow-up study (median time 25 months; range 3-108 months). The patients were registered between January 1996 and July 2001 and followed until December 2004. Twenty-seven Swedish hospitals contributed with follow-up results. Methods: Diagnostic procedures were undertaken according to a protocol including reinvestigation with Computed tomography scans after 3-6 months. 15-18 months and 27-30 months, as well as hormonal evaluation at baseline and after 27-30 months of follow-up. Operation was recommended when the incidentaloma size increased or if there was a suspicion of a hypersecreting tumour. Results: The median age at diagnosis of the 229 patients included in the follow-up study was 64 years (range 28-84 years) and the median size of the adrenal incidentalomas when discovered was 2.5 cm (range 1-8 cm). During the follow-up period, an increase in incidentaloma size of >= 0.5 cm was reported in 17 (7.4%) and of >= 1.0 cm was reported in 12 (5.2%,) of the 229 patients. A decrease in size was seen in 12 patients (5.2%). A hypersecreting tumour was found in 2%, of the hormonally investigated patients: Cushing's syndrome (n = 2) and phaeochromocytoma (n = 1). Eleven patients underwent adrenalectomy, but no cases of primary adrenal malignancy were observed. Conclusions: Patients with adrenal incidentaloma had a low risk of developing malignancy or hormonal hypersecretion during a short-term follow-up period.},
  author       = {Bulow, B and Jansson, S and Juhlin, C and Steen, L and Thoren, M and Wahrenberg, L and Valdemarsson, Stig and Wangberg, B and Ahrén, Bo},
  issn         = {1479-683X},
  language     = {eng},
  number       = {3},
  pages        = {419--423},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology},
  title        = {Adrenal incidentaloma - follow-up results from a Swedish prospective study},
  url          = {http://dx.doi.org/10.1530/eje.1.02110},
  doi          = {10.1530/eje.1.02110},
  volume       = {154},
  year         = {2006},
}