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A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy : Design, Dosimetry and Biological Pilot Study

Breslin, Thomas LU ; Paino, Jason ; Wegner, Marie ; Engels, Elette ; Fiedler, Stefan ; Forrester, Helen ; Rennau, Hannes ; Bustillo, John ; Cameron, Matthew and Häusermann, Daniel , et al. (2023) In Biomimetics 8(2).
Abstract

The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT)... (More)

The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anthropomorphic phantom, CT scan, dosimetry, experimental radiotherapy, microbeam radiotherapy (MRT), therapy planning, tissue-equivalent materials
in
Biomimetics
volume
8
issue
2
article number
230
publisher
MDPI AG
external identifiers
  • pmid:37366825
  • scopus:85163844776
ISSN
2313-7673
DOI
10.3390/biomimetics8020230
language
English
LU publication?
yes
id
4109dddd-2c8d-4817-9dd9-a6deb17c0cc5
date added to LUP
2023-09-18 12:55:12
date last changed
2024-04-19 02:17:13
@article{4109dddd-2c8d-4817-9dd9-a6deb17c0cc5,
  abstract     = {{<p>The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.</p>}},
  author       = {{Breslin, Thomas and Paino, Jason and Wegner, Marie and Engels, Elette and Fiedler, Stefan and Forrester, Helen and Rennau, Hannes and Bustillo, John and Cameron, Matthew and Häusermann, Daniel and Hall, Christopher and Krause, Dieter and Hildebrandt, Guido and Lerch, Michael and Schültke, Elisabeth}},
  issn         = {{2313-7673}},
  keywords     = {{anthropomorphic phantom; CT scan; dosimetry; experimental radiotherapy; microbeam radiotherapy (MRT); therapy planning; tissue-equivalent materials}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{MDPI AG}},
  series       = {{Biomimetics}},
  title        = {{A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy : Design, Dosimetry and Biological Pilot Study}},
  url          = {{http://dx.doi.org/10.3390/biomimetics8020230}},
  doi          = {{10.3390/biomimetics8020230}},
  volume       = {{8}},
  year         = {{2023}},
}