Long-term assessment of striatal dopamine transporters in parkinsonian patients with intrastriatal embryonic mesencephalic grafts
(2006) In European Journal of Nuclear Medicine and Molecular Imaging 33(4). p.407-411- Abstract
- Purpose: Single-photon emission computed tomography (SPECT) of striatal dopamine transporters (DAT) has been used to demonstrate presynaptic dopaminergic dysfunction and to monitor the progression of Parkinson's disease. In parkinsonian patients who were implanted with embryonic mesencephalic tissue in the striatum, positron emission tomography (PET) has shown an increase in striatal [F-18]dopa uptake as an indicator of graft survival and striatal reinnervation. The aim of this study was to investigate two patients who had undergone bilateral intrastriatal transplantation of human embryonic mesencephalic tissue using SPECT and the I-123-labelled DAT ligand N-(3-iodopropen-2-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl) tropane (IPT).... (More)
- Purpose: Single-photon emission computed tomography (SPECT) of striatal dopamine transporters (DAT) has been used to demonstrate presynaptic dopaminergic dysfunction and to monitor the progression of Parkinson's disease. In parkinsonian patients who were implanted with embryonic mesencephalic tissue in the striatum, positron emission tomography (PET) has shown an increase in striatal [F-18]dopa uptake as an indicator of graft survival and striatal reinnervation. The aim of this study was to investigate two patients who had undergone bilateral intrastriatal transplantation of human embryonic mesencephalic tissue using SPECT and the I-123-labelled DAT ligand N-(3-iodopropen-2-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl) tropane (IPT). Methods: Two patients were subjected to [I-123]IPT SPECT according to a standardised protocol prospectively and repeatedly up to 8 years after transplantation. Results: From baseline to year 3 after transplantation, mean striatal DAT availability increased by a mean of 61% (93% and 29% in patients 1 and 2, respectively). It then remained relatively stable up to 8 years in patient 2, but increased further by another 77% of baseline values in patient 1. Clinically, both patients experienced a moderate improvement in motor performance but developed moderate (patient 2) to severe (patient 1) off-medication dyskinesias. Conclusion: Our data indicate that DAT imaging using IPT and SPECT can be used to demonstrate graft survival following dopaminergic tissue implantation. Because SPECT with DAT ligands is widely available in the routine clinical setting, this methodology may be a useful alternative to [F-18]dopa PET for repeated scanning of grafted parkinsonian patients. The relevance of the long-term increase in DAT binding for the development of off-medication dyskinesias remains to be elucidated further. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/411206
- author
- Pogarell, O ; Koch, W ; Gildehaus, F ; Kupsch, A ; Lindvall, Olle LU ; Oertel, W and Tatsch, K
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dopamine transporter, SPECT, Parkinson's disease, striatal grafts
- in
- European Journal of Nuclear Medicine and Molecular Imaging
- volume
- 33
- issue
- 4
- pages
- 407 - 411
- publisher
- Springer
- external identifiers
-
- wos:000236913100002
- pmid:16447045
- scopus:33645860519
- ISSN
- 1619-7070
- DOI
- 10.1007/s00259-005-0032-z
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160)
- id
- 6c20b630-7aac-4e2a-a895-10c90a3dfa0c (old id 411206)
- date added to LUP
- 2016-04-01 12:25:19
- date last changed
- 2022-01-27 03:32:54
@article{6c20b630-7aac-4e2a-a895-10c90a3dfa0c,
abstract = {{Purpose: Single-photon emission computed tomography (SPECT) of striatal dopamine transporters (DAT) has been used to demonstrate presynaptic dopaminergic dysfunction and to monitor the progression of Parkinson's disease. In parkinsonian patients who were implanted with embryonic mesencephalic tissue in the striatum, positron emission tomography (PET) has shown an increase in striatal [F-18]dopa uptake as an indicator of graft survival and striatal reinnervation. The aim of this study was to investigate two patients who had undergone bilateral intrastriatal transplantation of human embryonic mesencephalic tissue using SPECT and the I-123-labelled DAT ligand N-(3-iodopropen-2-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl) tropane (IPT). Methods: Two patients were subjected to [I-123]IPT SPECT according to a standardised protocol prospectively and repeatedly up to 8 years after transplantation. Results: From baseline to year 3 after transplantation, mean striatal DAT availability increased by a mean of 61% (93% and 29% in patients 1 and 2, respectively). It then remained relatively stable up to 8 years in patient 2, but increased further by another 77% of baseline values in patient 1. Clinically, both patients experienced a moderate improvement in motor performance but developed moderate (patient 2) to severe (patient 1) off-medication dyskinesias. Conclusion: Our data indicate that DAT imaging using IPT and SPECT can be used to demonstrate graft survival following dopaminergic tissue implantation. Because SPECT with DAT ligands is widely available in the routine clinical setting, this methodology may be a useful alternative to [F-18]dopa PET for repeated scanning of grafted parkinsonian patients. The relevance of the long-term increase in DAT binding for the development of off-medication dyskinesias remains to be elucidated further.}},
author = {{Pogarell, O and Koch, W and Gildehaus, F and Kupsch, A and Lindvall, Olle and Oertel, W and Tatsch, K}},
issn = {{1619-7070}},
keywords = {{dopamine transporter; SPECT; Parkinson's disease; striatal grafts}},
language = {{eng}},
number = {{4}},
pages = {{407--411}},
publisher = {{Springer}},
series = {{European Journal of Nuclear Medicine and Molecular Imaging}},
title = {{Long-term assessment of striatal dopamine transporters in parkinsonian patients with intrastriatal embryonic mesencephalic grafts}},
url = {{http://dx.doi.org/10.1007/s00259-005-0032-z}},
doi = {{10.1007/s00259-005-0032-z}},
volume = {{33}},
year = {{2006}},
}