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Drug effect evaluation during permanent atrial fibrillation using an AV-node model

Sandberg, Frida LU ; Corino, Valentina D A; Ulimoen, Sara Reinvik; Enger, Steve; Tveit, Arnljot; Mainardi, Luca T.; Platonov, Pyotr LU and Sornmo, Leif LU (2013) 2013 40th Computing in Cardiology Conference, CinC 2013 40. p.1243-1246
Abstract

The purpose of the present study is to evaluate the effect of rate control drugs on the AV node characteristics during atrial fibrillation (AF) using a model-based approach. A statistical model of the AV nodal function is employed, defined by parameters which characterize the arrival rate of atrial impulses, the refractoriness of the fast and the slow AV-nodal pathway and the probability of atrial impulse to pass through either of the two pathways. The RATAF (RATe control in Atrial Fibrillation) study database consists of recordings from 60 patients with permanent AF at baseline and on treatment with metoprolol, verapamil, diltiazem and carvedilol, respectively. The resulting model parameter estimates indicate that the refractory period... (More)

The purpose of the present study is to evaluate the effect of rate control drugs on the AV node characteristics during atrial fibrillation (AF) using a model-based approach. A statistical model of the AV nodal function is employed, defined by parameters which characterize the arrival rate of atrial impulses, the refractoriness of the fast and the slow AV-nodal pathway and the probability of atrial impulse to pass through either of the two pathways. The RATAF (RATe control in Atrial Fibrillation) study database consists of recordings from 60 patients with permanent AF at baseline and on treatment with metoprolol, verapamil, diltiazem and carvedilol, respectively. The resulting model parameter estimates indicate that the refractory period of the slow pathway as well as that of the fast pathway increased significantly during treatment with all four drugs. The results suggest that the proposed AV-node model can be used for non-invasive evaluation of the effect of rate control drugs.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Computing in Cardiology 2013, CinC 2013
volume
40
pages
4 pages
conference name
2013 40th Computing in Cardiology Conference, CinC 2013
conference location
Zaragoza, Spain
conference dates
2013-09-22 - 2013-09-25
external identifiers
  • scopus:84894202923
ISBN
9781479908844
language
English
LU publication?
yes
id
4112c2ac-e98d-4efa-a6b0-b9813c130f10
alternative location
http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=6713609
date added to LUP
2017-08-09 15:17:35
date last changed
2019-02-20 10:46:14
@inproceedings{4112c2ac-e98d-4efa-a6b0-b9813c130f10,
  abstract     = {<p>The purpose of the present study is to evaluate the effect of rate control drugs on the AV node characteristics during atrial fibrillation (AF) using a model-based approach. A statistical model of the AV nodal function is employed, defined by parameters which characterize the arrival rate of atrial impulses, the refractoriness of the fast and the slow AV-nodal pathway and the probability of atrial impulse to pass through either of the two pathways. The RATAF (RATe control in Atrial Fibrillation) study database consists of recordings from 60 patients with permanent AF at baseline and on treatment with metoprolol, verapamil, diltiazem and carvedilol, respectively. The resulting model parameter estimates indicate that the refractory period of the slow pathway as well as that of the fast pathway increased significantly during treatment with all four drugs. The results suggest that the proposed AV-node model can be used for non-invasive evaluation of the effect of rate control drugs.</p>},
  author       = {Sandberg, Frida and Corino, Valentina D A and Ulimoen, Sara Reinvik and Enger, Steve and Tveit, Arnljot and Mainardi, Luca T. and Platonov, Pyotr and Sornmo, Leif},
  isbn         = {9781479908844},
  language     = {eng},
  location     = {Zaragoza, Spain},
  pages        = {1243--1246},
  title        = {Drug effect evaluation during permanent atrial fibrillation using an AV-node model},
  volume       = {40},
  year         = {2013},
}