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Thiol-specific and nonspecific interactions between DNA and gold nanoparticles

Cárdenas, Marité LU ; Barauskas, Justas LU ; Schillén, Karin LU orcid ; Brennan, JL ; Brust, M and Nylander, Tommy LU (2006) In Langmuir 22(7). p.3294-3299
Abstract
The contribution of nonspecific interactions to the overall interactions of thiol-ssDNA and dsDNA macromolecules with gold nanoparticles was investigated. A systematic investigation utilizing dynamic light scattering and cryogenic transmission electron microscopy has been per-formed to directly measure and visualize the changes in particle size and appearance during functionalization of gold nanoparticles with thiol-ssDNA and nonthiolated dsDNA. The results show that both thiol-ssDNA and dsDNA do stabilize gold nanoparticle dispersions, but possible nonspecific interactions between the hydrophobic DNA bases and the gold surface promote interparticle interactions and cause aggregation within rather a short period of time. We also discuss... (More)
The contribution of nonspecific interactions to the overall interactions of thiol-ssDNA and dsDNA macromolecules with gold nanoparticles was investigated. A systematic investigation utilizing dynamic light scattering and cryogenic transmission electron microscopy has been per-formed to directly measure and visualize the changes in particle size and appearance during functionalization of gold nanoparticles with thiol-ssDNA and nonthiolated dsDNA. The results show that both thiol-ssDNA and dsDNA do stabilize gold nanoparticle dispersions, but possible nonspecific interactions between the hydrophobic DNA bases and the gold surface promote interparticle interactions and cause aggregation within rather a short period of time. We also discuss the adsorption mechanisms of dsDNA and thiol-ssDNA to gold particles. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
22
issue
7
pages
3294 - 3299
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000236843300060
  • scopus:33645499348
ISSN
0743-7463
DOI
10.1021/la0530438
language
English
LU publication?
yes
id
570ac30a-9627-4570-a5e0-59e19424d882 (old id 413990)
date added to LUP
2016-04-01 12:28:30
date last changed
2021-08-04 04:30:04
@article{570ac30a-9627-4570-a5e0-59e19424d882,
  abstract     = {The contribution of nonspecific interactions to the overall interactions of thiol-ssDNA and dsDNA macromolecules with gold nanoparticles was investigated. A systematic investigation utilizing dynamic light scattering and cryogenic transmission electron microscopy has been per-formed to directly measure and visualize the changes in particle size and appearance during functionalization of gold nanoparticles with thiol-ssDNA and nonthiolated dsDNA. The results show that both thiol-ssDNA and dsDNA do stabilize gold nanoparticle dispersions, but possible nonspecific interactions between the hydrophobic DNA bases and the gold surface promote interparticle interactions and cause aggregation within rather a short period of time. We also discuss the adsorption mechanisms of dsDNA and thiol-ssDNA to gold particles.},
  author       = {Cárdenas, Marité and Barauskas, Justas and Schillén, Karin and Brennan, JL and Brust, M and Nylander, Tommy},
  issn         = {0743-7463},
  language     = {eng},
  number       = {7},
  pages        = {3294--3299},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Langmuir},
  title        = {Thiol-specific and nonspecific interactions between DNA and gold nanoparticles},
  url          = {http://dx.doi.org/10.1021/la0530438},
  doi          = {10.1021/la0530438},
  volume       = {22},
  year         = {2006},
}