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Measurement Techniques for Respiratory Tract Deposition of Airborne Nanoparticles: A Critical Review.

Löndahl, Jakob LU ; Möller, Winfried; Pagels, Joakim LU ; Kreyling, Wolfgang G; Swietlicki, Erik LU and Schmid, Otmar (2014) In Journal of Aerosol Medicine and Pulmonary Drug Delivery 27(4). p.229-254
Abstract
Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicine. Over the last century, around 50 studies have presented experimental data on lung deposition of nanoparticles (typical diameter≤100 nm, but here≤300 nm). These data show a considerable variability, partly due to differences in the applied methodologies. In this study, we review the experimental techniques for measuring respiratory tract... (More)
Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicine. Over the last century, around 50 studies have presented experimental data on lung deposition of nanoparticles (typical diameter≤100 nm, but here≤300 nm). These data show a considerable variability, partly due to differences in the applied methodologies. In this study, we review the experimental techniques for measuring respiratory tract deposition of nano-sized particles, analyze critical experimental design aspects causing measurement uncertainties, and suggest methodologies for future studies. It is shown that, although particle detection techniques have developed with time, the overall methodology in respiratory tract deposition experiments has not seen similar progress. Available experience from previous research has often not been incorporated, and some methodological design aspects that were overlooked in 30-70% of all studies may have biased the experimental data. This has contributed to a significant uncertainty on the absolute value of the lung deposition fraction of nanoparticles. We estimate the impact of the design aspects on obtained data, discuss solutions to minimize errors, and highlight gaps in the available experimental set of data. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aerosol, engineered nanoparticles, dosimetry, health, inhalation, NSAM, ultrafine particles, pulmonary, lung deposition
in
Journal of Aerosol Medicine and Pulmonary Drug Delivery
volume
27
issue
4
pages
229 - 254
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:24151837
  • wos:000340520400082
  • scopus:84905443848
ISSN
1941-2703
DOI
10.1089/jamp.2013.1044
language
English
LU publication?
yes
id
0faba5ba-7ae3-466b-8da0-feb9c5b22c8d (old id 4143063)
date added to LUP
2013-11-08 13:49:39
date last changed
2017-09-10 03:20:24
@article{0faba5ba-7ae3-466b-8da0-feb9c5b22c8d,
  abstract     = {Abstract Determination of the respiratory tract deposition of airborne particles is critical for risk assessment of air pollution, inhaled drug delivery, and understanding of respiratory disease. With the advent of nanotechnology, there has been an increasing interest in the measurement of pulmonary deposition of nanoparticles because of their unique properties in inhalation toxicology and medicine. Over the last century, around 50 studies have presented experimental data on lung deposition of nanoparticles (typical diameter≤100 nm, but here≤300 nm). These data show a considerable variability, partly due to differences in the applied methodologies. In this study, we review the experimental techniques for measuring respiratory tract deposition of nano-sized particles, analyze critical experimental design aspects causing measurement uncertainties, and suggest methodologies for future studies. It is shown that, although particle detection techniques have developed with time, the overall methodology in respiratory tract deposition experiments has not seen similar progress. Available experience from previous research has often not been incorporated, and some methodological design aspects that were overlooked in 30-70% of all studies may have biased the experimental data. This has contributed to a significant uncertainty on the absolute value of the lung deposition fraction of nanoparticles. We estimate the impact of the design aspects on obtained data, discuss solutions to minimize errors, and highlight gaps in the available experimental set of data.},
  author       = {Löndahl, Jakob and Möller, Winfried and Pagels, Joakim and Kreyling, Wolfgang G and Swietlicki, Erik and Schmid, Otmar},
  issn         = {1941-2703},
  keyword      = {aerosol,engineered nanoparticles,dosimetry,health,inhalation,NSAM,ultrafine particles,pulmonary,lung deposition},
  language     = {eng},
  number       = {4},
  pages        = {229--254},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Journal of Aerosol Medicine and Pulmonary Drug Delivery},
  title        = {Measurement Techniques for Respiratory Tract Deposition of Airborne Nanoparticles: A Critical Review.},
  url          = {http://dx.doi.org/10.1089/jamp.2013.1044},
  volume       = {27},
  year         = {2014},
}