A Pediatric Bone Mass Scan Has Poor Ability to Predict Adult Bone Mass: A 28-Year Prospective Study in 214 Children.
(2014) In Calcified Tissue International 94(2). p.232-239- Abstract
- As the correlation of bone mass from childhood to adulthood is unclear, we conducted a long-term prospective observational study to determine if a pediatric bone mass scan could predict adult bone mass. We measured cortical bone mineral content (BMC [g]), bone mineral density (BMD [g/cm(2)]), and bone width (cm) in the distal forearm by single photon absorptiometry in 120 boys and 94 girls with a mean age of 10 years (range 3-17) and mean 28 years (range 25-29) later. We calculated individual and age-specific bone mass Z scores, using the control cohort included at baseline as reference, and evaluated correlations between the two measurements with Pearson's correlation coefficient. Individual Z scores were also stratified in quartiles to... (More)
- As the correlation of bone mass from childhood to adulthood is unclear, we conducted a long-term prospective observational study to determine if a pediatric bone mass scan could predict adult bone mass. We measured cortical bone mineral content (BMC [g]), bone mineral density (BMD [g/cm(2)]), and bone width (cm) in the distal forearm by single photon absorptiometry in 120 boys and 94 girls with a mean age of 10 years (range 3-17) and mean 28 years (range 25-29) later. We calculated individual and age-specific bone mass Z scores, using the control cohort included at baseline as reference, and evaluated correlations between the two measurements with Pearson's correlation coefficient. Individual Z scores were also stratified in quartiles to register movements between quartiles from growth to adulthood. BMD Z scores in childhood and adulthood correlated in both boys (r = 0.35, p < 0.0001) and girls (r = 0.50, p < 0.0001) and in both children ≥10 years at baseline (boys r = 0.43 and girls r = 0.58, both p < 0.0001) and children <10 years at baseline (boys r = 0.26 and girls r = 0.40, both p < 0.05). Of the children in the lowest quartile of BMD, 58 % had left the lowest quartile in adulthood. A pediatric bone scan with a value in the lowest quartile had a sensitivity of 48 % (95 % confidence interval [CI] 27-69 %) and a specificity of 76 % (95 % CI 66-84 %) to identify individuals who would remain in the lowest quartile also in adulthood. Childhood forearm BMD explained 12 % of the variance in adult BMD in men and 25 % in women. A pediatric distal forearm BMD scan has poor ability to predict adult bone mass. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4143593
- author
- Buttazzoni, Christian LU ; Rosengren, Björn LU ; Tveit, Magnus LU ; Landin, Lennart LU ; Nilsson, Jan-Åke LU and Karlsson, Magnus LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Calcified Tissue International
- volume
- 94
- issue
- 2
- pages
- 232 - 239
- publisher
- Springer
- external identifiers
-
- pmid:24101230
- wos:000330827700012
- scopus:84893278568
- pmid:24101230
- ISSN
- 1432-0827
- DOI
- 10.1007/s00223-013-9802-y
- language
- English
- LU publication?
- yes
- id
- 0309daf1-86ba-4936-b896-aca26a160208 (old id 4143593)
- date added to LUP
- 2016-04-01 10:51:50
- date last changed
- 2024-02-22 12:40:13
@article{0309daf1-86ba-4936-b896-aca26a160208, abstract = {{As the correlation of bone mass from childhood to adulthood is unclear, we conducted a long-term prospective observational study to determine if a pediatric bone mass scan could predict adult bone mass. We measured cortical bone mineral content (BMC [g]), bone mineral density (BMD [g/cm(2)]), and bone width (cm) in the distal forearm by single photon absorptiometry in 120 boys and 94 girls with a mean age of 10 years (range 3-17) and mean 28 years (range 25-29) later. We calculated individual and age-specific bone mass Z scores, using the control cohort included at baseline as reference, and evaluated correlations between the two measurements with Pearson's correlation coefficient. Individual Z scores were also stratified in quartiles to register movements between quartiles from growth to adulthood. BMD Z scores in childhood and adulthood correlated in both boys (r = 0.35, p < 0.0001) and girls (r = 0.50, p < 0.0001) and in both children ≥10 years at baseline (boys r = 0.43 and girls r = 0.58, both p < 0.0001) and children <10 years at baseline (boys r = 0.26 and girls r = 0.40, both p < 0.05). Of the children in the lowest quartile of BMD, 58 % had left the lowest quartile in adulthood. A pediatric bone scan with a value in the lowest quartile had a sensitivity of 48 % (95 % confidence interval [CI] 27-69 %) and a specificity of 76 % (95 % CI 66-84 %) to identify individuals who would remain in the lowest quartile also in adulthood. Childhood forearm BMD explained 12 % of the variance in adult BMD in men and 25 % in women. A pediatric distal forearm BMD scan has poor ability to predict adult bone mass.}}, author = {{Buttazzoni, Christian and Rosengren, Björn and Tveit, Magnus and Landin, Lennart and Nilsson, Jan-Åke and Karlsson, Magnus}}, issn = {{1432-0827}}, language = {{eng}}, number = {{2}}, pages = {{232--239}}, publisher = {{Springer}}, series = {{Calcified Tissue International}}, title = {{A Pediatric Bone Mass Scan Has Poor Ability to Predict Adult Bone Mass: A 28-Year Prospective Study in 214 Children.}}, url = {{https://lup.lub.lu.se/search/files/2193919/4350744.pdf}}, doi = {{10.1007/s00223-013-9802-y}}, volume = {{94}}, year = {{2014}}, }