A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin
(2006) In Phytotherapy Research 20(3). p.178-183- Abstract
- Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C-Med-100, a Cat's Claw water extract, is the only documented natural source of components that can up-regulate simultaneously both DNA repair and antiinflammation, its ability to modulate DNA repair in human skin organ cultures was undertaken. For this purpose skin cultures were treated with or without 5 mg/mL C-Med-100, irradiated with 0-100 mJ/cm(2) UVB, and microscopically... (More)
- Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C-Med-100, a Cat's Claw water extract, is the only documented natural source of components that can up-regulate simultaneously both DNA repair and antiinflammation, its ability to modulate DNA repair in human skin organ cultures was undertaken. For this purpose skin cultures were treated with or without 5 mg/mL C-Med-100, irradiated with 0-100 mJ/cm(2) UVB, and microscopically analysed for necrosis as well as the level of pyrimidine dimers using immunofluorescent TT-dimer antibody staining. The data clearly demonstrated that co-incubation with C-Med-100 reduced skin cell death from UV exposure, and this protection was accounted for by a concomitant increase in DNA repair. Based on these results, it was concluded that C-Med-100 was a natural plant extract worthy of further consideration as a sunscreen product. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/414734
- author
- Mammone, T ; Silver, Christina LU ; Gan, D ; Giampapa, V and Pero, RW
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- quinic acid esters, C-Med-100, UV radiation protection, UV induced thymidine dimers, DNA repair
- in
- Phytotherapy Research
- volume
- 20
- issue
- 3
- pages
- 178 - 183
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000236482800003
- pmid:16521105
- scopus:33645466656
- pmid:16521105
- ISSN
- 1099-1573
- DOI
- 10.1002/ptr.1827
- language
- English
- LU publication?
- yes
- id
- 646ea5be-35e0-49aa-bfbd-d5802a2db9b9 (old id 414734)
- date added to LUP
- 2016-04-01 12:19:36
- date last changed
- 2022-04-13 17:28:02
@article{646ea5be-35e0-49aa-bfbd-d5802a2db9b9,
abstract = {{Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C-Med-100, a Cat's Claw water extract, is the only documented natural source of components that can up-regulate simultaneously both DNA repair and antiinflammation, its ability to modulate DNA repair in human skin organ cultures was undertaken. For this purpose skin cultures were treated with or without 5 mg/mL C-Med-100, irradiated with 0-100 mJ/cm(2) UVB, and microscopically analysed for necrosis as well as the level of pyrimidine dimers using immunofluorescent TT-dimer antibody staining. The data clearly demonstrated that co-incubation with C-Med-100 reduced skin cell death from UV exposure, and this protection was accounted for by a concomitant increase in DNA repair. Based on these results, it was concluded that C-Med-100 was a natural plant extract worthy of further consideration as a sunscreen product.}},
author = {{Mammone, T and Silver, Christina and Gan, D and Giampapa, V and Pero, RW}},
issn = {{1099-1573}},
keywords = {{quinic acid esters; C-Med-100; UV radiation protection; UV induced thymidine dimers; DNA repair}},
language = {{eng}},
number = {{3}},
pages = {{178--183}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Phytotherapy Research}},
title = {{A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin}},
url = {{http://dx.doi.org/10.1002/ptr.1827}},
doi = {{10.1002/ptr.1827}},
volume = {{20}},
year = {{2006}},
}