Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin

Mammone, T ; Silver, Christina LU ; Gan, D ; Giampapa, V and Pero, RW (2006) In Phytotherapy Research 20(3). p.178-183
Abstract
Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C-Med-100, a Cat's Claw water extract, is the only documented natural source of components that can up-regulate simultaneously both DNA repair and antiinflammation, its ability to modulate DNA repair in human skin organ cultures was undertaken. For this purpose skin cultures were treated with or without 5 mg/mL C-Med-100, irradiated with 0-100 mJ/cm(2) UVB, and microscopically... (More)
Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C-Med-100, a Cat's Claw water extract, is the only documented natural source of components that can up-regulate simultaneously both DNA repair and antiinflammation, its ability to modulate DNA repair in human skin organ cultures was undertaken. For this purpose skin cultures were treated with or without 5 mg/mL C-Med-100, irradiated with 0-100 mJ/cm(2) UVB, and microscopically analysed for necrosis as well as the level of pyrimidine dimers using immunofluorescent TT-dimer antibody staining. The data clearly demonstrated that co-incubation with C-Med-100 reduced skin cell death from UV exposure, and this protection was accounted for by a concomitant increase in DNA repair. Based on these results, it was concluded that C-Med-100 was a natural plant extract worthy of further consideration as a sunscreen product. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
quinic acid esters, C-Med-100, UV radiation protection, UV induced thymidine dimers, DNA repair
in
Phytotherapy Research
volume
20
issue
3
pages
178 - 183
publisher
John Wiley and Sons
external identifiers
  • wos:000236482800003
  • pmid:16521105
  • scopus:33645466656
  • pmid:16521105
ISSN
1099-1573
DOI
10.1002/ptr.1827
language
English
LU publication?
yes
id
646ea5be-35e0-49aa-bfbd-d5802a2db9b9 (old id 414734)
date added to LUP
2016-04-01 12:19:36
date last changed
2021-06-23 04:08:35
@article{646ea5be-35e0-49aa-bfbd-d5802a2db9b9,
  abstract     = {Cat's Claw (Uncaria tomentosa) water extracts, essentially free of oxindole alkaloids, have been shown to possess a broad spectrum of biological activity including DNA repair enhancement and antiinflammatory properties. These two biological mechanisms are key molecular targets to develop treatments that protect skin exposed to ultraviolet light from the sun. Because C-Med-100, a Cat's Claw water extract, is the only documented natural source of components that can up-regulate simultaneously both DNA repair and antiinflammation, its ability to modulate DNA repair in human skin organ cultures was undertaken. For this purpose skin cultures were treated with or without 5 mg/mL C-Med-100, irradiated with 0-100 mJ/cm(2) UVB, and microscopically analysed for necrosis as well as the level of pyrimidine dimers using immunofluorescent TT-dimer antibody staining. The data clearly demonstrated that co-incubation with C-Med-100 reduced skin cell death from UV exposure, and this protection was accounted for by a concomitant increase in DNA repair. Based on these results, it was concluded that C-Med-100 was a natural plant extract worthy of further consideration as a sunscreen product.},
  author       = {Mammone, T and Silver, Christina and Gan, D and Giampapa, V and Pero, RW},
  issn         = {1099-1573},
  language     = {eng},
  number       = {3},
  pages        = {178--183},
  publisher    = {John Wiley and Sons},
  series       = {Phytotherapy Research},
  title        = {A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin},
  url          = {http://dx.doi.org/10.1002/ptr.1827},
  doi          = {10.1002/ptr.1827},
  volume       = {20},
  year         = {2006},
}