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3-D Monte Carlo-based scatter compensation in quantitative I-131SPECT reconstruction

Dewaraja, YK ; Ljungberg, Michael LU and Fessler, JA (2006) In IEEE Transactions on Nuclear Science 53(1). p.181-188
Abstract
We have implemented highly accurate Monte Carlo based scatter modeling (MCS) with 3-D ordered subsets expectation maximization (OSEM) reconstruction for I-131 single photon emission computed tomography (SPECT). The scatter is included in the statistical model as an additive term and attenuation and detector response are included in the forward/backprojector. In the present implementation of MCS, a simple multiple window-based estimate is used for the initial iterations and in the later iterations the Monte Carlo estimate is used for several iterations before it is updated. For I-131, MCS was evaluated and compared with triple energy window (TEW) scatter compensation using simulation studies of a mathematical phantom and a clinically... (More)
We have implemented highly accurate Monte Carlo based scatter modeling (MCS) with 3-D ordered subsets expectation maximization (OSEM) reconstruction for I-131 single photon emission computed tomography (SPECT). The scatter is included in the statistical model as an additive term and attenuation and detector response are included in the forward/backprojector. In the present implementation of MCS, a simple multiple window-based estimate is used for the initial iterations and in the later iterations the Monte Carlo estimate is used for several iterations before it is updated. For I-131, MCS was evaluated and compared with triple energy window (TEW) scatter compensation using simulation studies of a mathematical phantom and a clinically realistic voxel-phantom. Even after just two Monte Carlo updates, excellent agreement was found between the MCS estimate and the true scatter distribution. Accuracy and noise of the reconstructed images were superior with MCS compared to TEW. However, the improvement was not large, and in some cases may not justify the large computational requirements of MCS. Furthermore, it was shown that the TEW correction could be improved for most of the targets investigated here by applying a suitably chosen scaling factor to the scatter estimate. Finally clinical application of MCS was demonstrated by applying the method to an I-131 radioimmunotherapy (RIT) patient study. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
SPECT quantification, scatter correction, Monte Carlo, I-131SPECT, image reconstruction
in
IEEE Transactions on Nuclear Science
volume
53
issue
1
pages
181 - 188
publisher
IEEE - Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • wos:000236473800030
  • scopus:33645662166
  • pmid:20104252
ISSN
0018-9499
DOI
10.1109/TNS.2005.862956
language
English
LU publication?
yes
id
f8b1f595-8177-4412-b3ae-7fc8e466dc7b (old id 414857)
date added to LUP
2016-04-01 16:37:39
date last changed
2020-04-22 03:32:28
@article{f8b1f595-8177-4412-b3ae-7fc8e466dc7b,
  abstract     = {We have implemented highly accurate Monte Carlo based scatter modeling (MCS) with 3-D ordered subsets expectation maximization (OSEM) reconstruction for I-131 single photon emission computed tomography (SPECT). The scatter is included in the statistical model as an additive term and attenuation and detector response are included in the forward/backprojector. In the present implementation of MCS, a simple multiple window-based estimate is used for the initial iterations and in the later iterations the Monte Carlo estimate is used for several iterations before it is updated. For I-131, MCS was evaluated and compared with triple energy window (TEW) scatter compensation using simulation studies of a mathematical phantom and a clinically realistic voxel-phantom. Even after just two Monte Carlo updates, excellent agreement was found between the MCS estimate and the true scatter distribution. Accuracy and noise of the reconstructed images were superior with MCS compared to TEW. However, the improvement was not large, and in some cases may not justify the large computational requirements of MCS. Furthermore, it was shown that the TEW correction could be improved for most of the targets investigated here by applying a suitably chosen scaling factor to the scatter estimate. Finally clinical application of MCS was demonstrated by applying the method to an I-131 radioimmunotherapy (RIT) patient study.},
  author       = {Dewaraja, YK and Ljungberg, Michael and Fessler, JA},
  issn         = {0018-9499},
  language     = {eng},
  number       = {1},
  pages        = {181--188},
  publisher    = {IEEE - Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Nuclear Science},
  title        = {3-D Monte Carlo-based scatter compensation in quantitative I-131SPECT reconstruction},
  url          = {http://dx.doi.org/10.1109/TNS.2005.862956},
  doi          = {10.1109/TNS.2005.862956},
  volume       = {53},
  year         = {2006},
}