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Hypertension prevalence in obstructive sleep apnoea and sex: a population-based case-control study

Hedner, J ; Bengtsson Boström, Kristina LU ; Peker, Y ; Grote, L ; Rastam, L and Lindblad, Ulf LU (2006) In European Respiratory Journal 27(3). p.564-570
Abstract
Obstructive sleep apnoea (OSA) is a recognised risk factor for hypertension (HT). The current authors investigated confounders of this association in a sex-balanced community-based sample of patients with HT (n=161) from the Skaraborg Hypertension and Diabetes Project (n=1,149) and normotensive controls (n=183) from an age and sex stratified community-based population sample (n=1,109). All participants underwent ambulatory home polysomnography. Severe OSA (apnoea-plus-hypopnoea index (AHI) >= 30 events center dot h(-1)) was found in 47 and 25% of hypertensive and normotensive males, respectively. The corresponding numbers in females were 26 and 24%, respectively. The odds ratio (OR) for HT increased across AHI tertiles from 1.0 to 2.1... (More)
Obstructive sleep apnoea (OSA) is a recognised risk factor for hypertension (HT). The current authors investigated confounders of this association in a sex-balanced community-based sample of patients with HT (n=161) from the Skaraborg Hypertension and Diabetes Project (n=1,149) and normotensive controls (n=183) from an age and sex stratified community-based population sample (n=1,109). All participants underwent ambulatory home polysomnography. Severe OSA (apnoea-plus-hypopnoea index (AHI) >= 30 events center dot h(-1)) was found in 47 and 25% of hypertensive and normotensive males, respectively. The corresponding numbers in females were 26 and 24%, respectively. The odds ratio (OR) for HT increased across AHI tertiles from 1.0 to 2.1 (95% confidence interval: 0.9-4.5) and 1.0 to 3.7 (95% CI: 1.7-8.2) in males, but not in females where the OR increased from 1.0 to 1.8 (95% CI: 0.8-3.9) and 1.0 to 1.6 (95% CI: 0.7-3.5). Regression analysis correcting for age, body mass index (or waist-hip ratio) and smoking did not eliminate the association between OSA and HT in males. The present data suggest that obstructive sleep apnoea is highly prevalent in both the general population and in patients with known hypertension. The contribution of obstructive sleep apnoea to hypertension risk may be sex dependent and higher in males than in females. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
females, males, population-based study, sex, sleep apnoea, hypertension
in
European Respiratory Journal
volume
27
issue
3
pages
564 - 570
publisher
European Respiratory Society
external identifiers
  • wos:000235962200018
  • pmid:16507857
  • scopus:33644867188
ISSN
1399-3003
DOI
10.1183/09031936.06.00042105
language
English
LU publication?
yes
id
37ad1eea-61d3-43e0-b284-651f5c0c34b8 (old id 416498)
alternative location
http://erj.ersjournals.com/cgi/content/abstract/27/3/564
date added to LUP
2016-04-01 11:47:07
date last changed
2021-09-22 03:09:34
@article{37ad1eea-61d3-43e0-b284-651f5c0c34b8,
  abstract     = {Obstructive sleep apnoea (OSA) is a recognised risk factor for hypertension (HT). The current authors investigated confounders of this association in a sex-balanced community-based sample of patients with HT (n=161) from the Skaraborg Hypertension and Diabetes Project (n=1,149) and normotensive controls (n=183) from an age and sex stratified community-based population sample (n=1,109). All participants underwent ambulatory home polysomnography. Severe OSA (apnoea-plus-hypopnoea index (AHI) >= 30 events center dot h(-1)) was found in 47 and 25% of hypertensive and normotensive males, respectively. The corresponding numbers in females were 26 and 24%, respectively. The odds ratio (OR) for HT increased across AHI tertiles from 1.0 to 2.1 (95% confidence interval: 0.9-4.5) and 1.0 to 3.7 (95% CI: 1.7-8.2) in males, but not in females where the OR increased from 1.0 to 1.8 (95% CI: 0.8-3.9) and 1.0 to 1.6 (95% CI: 0.7-3.5). Regression analysis correcting for age, body mass index (or waist-hip ratio) and smoking did not eliminate the association between OSA and HT in males. The present data suggest that obstructive sleep apnoea is highly prevalent in both the general population and in patients with known hypertension. The contribution of obstructive sleep apnoea to hypertension risk may be sex dependent and higher in males than in females.},
  author       = {Hedner, J and Bengtsson Boström, Kristina and Peker, Y and Grote, L and Rastam, L and Lindblad, Ulf},
  issn         = {1399-3003},
  language     = {eng},
  number       = {3},
  pages        = {564--570},
  publisher    = {European Respiratory Society},
  series       = {European Respiratory Journal},
  title        = {Hypertension prevalence in obstructive sleep apnoea and sex: a population-based case-control study},
  url          = {http://dx.doi.org/10.1183/09031936.06.00042105},
  doi          = {10.1183/09031936.06.00042105},
  volume       = {27},
  year         = {2006},
}