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Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening

Lindfors, L ; Skantze, P ; Skantze, U ; Rasmusson, M ; Zackrisson, A and Olsson, Ulf LU (2006) In Langmuir 22(3). p.906-910
Abstract
Amorphous drug nanosuspensions are prone to particle growth due to Ostwald ripening. By incorporating a second component of extremely low aqueous solubility, Ostwald ripening can be inhibited. These studies indicate that to inhibit ripening, the drug/inhibitor mixture (in the particles) must form a single phase. The drug/inhibitor mixture can be characterized by the interaction parameter chi using the Bragg-Williams theory, in which single phase mixtures are obtained for chi < 2. The chi parameter can be calculated from the (crystalline) solubility of the drug in the inhibitor, provided the inhibitor is a liquid, and the melting entropy and temperature of the drug.
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
22
issue
3
pages
906 - 910
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000235068100014
  • scopus:33244462200
  • pmid:16430247
ISSN
0743-7463
DOI
10.1021/la0523661
language
English
LU publication?
yes
id
36d5b0ea-fa1f-4d97-a08e-8ae6aa000e85 (old id 418105)
date added to LUP
2016-04-01 12:37:00
date last changed
2020-12-22 02:08:13
@article{36d5b0ea-fa1f-4d97-a08e-8ae6aa000e85,
  abstract     = {Amorphous drug nanosuspensions are prone to particle growth due to Ostwald ripening. By incorporating a second component of extremely low aqueous solubility, Ostwald ripening can be inhibited. These studies indicate that to inhibit ripening, the drug/inhibitor mixture (in the particles) must form a single phase. The drug/inhibitor mixture can be characterized by the interaction parameter chi using the Bragg-Williams theory, in which single phase mixtures are obtained for chi &lt; 2. The chi parameter can be calculated from the (crystalline) solubility of the drug in the inhibitor, provided the inhibitor is a liquid, and the melting entropy and temperature of the drug.},
  author       = {Lindfors, L and Skantze, P and Skantze, U and Rasmusson, M and Zackrisson, A and Olsson, Ulf},
  issn         = {0743-7463},
  language     = {eng},
  number       = {3},
  pages        = {906--910},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Langmuir},
  title        = {Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening},
  url          = {http://dx.doi.org/10.1021/la0523661},
  doi          = {10.1021/la0523661},
  volume       = {22},
  year         = {2006},
}