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Amorphous drug nanosuspensions. 2. Experimental determination of bulk monomer concentrations

Lindfors, L ; Forssen, S ; Skantze, P ; Skantze, U ; Zackrisson, A and Olsson, Ulf LU (2006) In Langmuir 22(3). p.911-916
Abstract
A simple turbidimetric method was developed to measure the bulk concentration of drug in nanosuspensions. The bulk concentrations measured were in the range from 1 mu M to 1 mM. The accuracy of the method was checked by determination of the bulk concentration of crystalline nanosuspensions, i.e., the crystalline solubility, which compared favorably to solubilities measured by a conventional method. Results obtained for amorphous nanosuspensions agreed with predictions using a theory describing the relative solubility between a supercooled liquid and a crystal. Further, it was found that the bulk concentration in Ostwald ripening inhibited amorphous nanosuspensions and could be lowered by incorporation of higher amounts of the inhibitor, in... (More)
A simple turbidimetric method was developed to measure the bulk concentration of drug in nanosuspensions. The bulk concentrations measured were in the range from 1 mu M to 1 mM. The accuracy of the method was checked by determination of the bulk concentration of crystalline nanosuspensions, i.e., the crystalline solubility, which compared favorably to solubilities measured by a conventional method. Results obtained for amorphous nanosuspensions agreed with predictions using a theory describing the relative solubility between a supercooled liquid and a crystal. Further, it was found that the bulk concentration in Ostwald ripening inhibited amorphous nanosuspensions and could be lowered by incorporation of higher amounts of the inhibitor, in agreement with predictions using the Bragg-Williams theory of nonideal solutions. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Langmuir
volume
22
issue
3
pages
911 - 916
publisher
The American Chemical Society (ACS)
external identifiers
  • wos:000235068100015
  • scopus:33244458483
ISSN
0743-7463
DOI
10.1021/la052367t
language
English
LU publication?
yes
id
a7fe77f6-a6ce-45f9-9294-75ad514ecd14 (old id 418112)
date added to LUP
2016-04-01 11:51:20
date last changed
2020-06-03 01:49:35
@article{a7fe77f6-a6ce-45f9-9294-75ad514ecd14,
  abstract     = {A simple turbidimetric method was developed to measure the bulk concentration of drug in nanosuspensions. The bulk concentrations measured were in the range from 1 mu M to 1 mM. The accuracy of the method was checked by determination of the bulk concentration of crystalline nanosuspensions, i.e., the crystalline solubility, which compared favorably to solubilities measured by a conventional method. Results obtained for amorphous nanosuspensions agreed with predictions using a theory describing the relative solubility between a supercooled liquid and a crystal. Further, it was found that the bulk concentration in Ostwald ripening inhibited amorphous nanosuspensions and could be lowered by incorporation of higher amounts of the inhibitor, in agreement with predictions using the Bragg-Williams theory of nonideal solutions.},
  author       = {Lindfors, L and Forssen, S and Skantze, P and Skantze, U and Zackrisson, A and Olsson, Ulf},
  issn         = {0743-7463},
  language     = {eng},
  number       = {3},
  pages        = {911--916},
  publisher    = {The American Chemical Society (ACS)},
  series       = {Langmuir},
  title        = {Amorphous drug nanosuspensions. 2. Experimental determination of bulk monomer concentrations},
  url          = {http://dx.doi.org/10.1021/la052367t},
  doi          = {10.1021/la052367t},
  volume       = {22},
  year         = {2006},
}