Effects of Dopamine Signaling on Recovery and Inflammation after Ischemic Stroke
(2014) In Lund University Faculty of Medicine Doctoral Dissertation Series 2014:4.- Abstract
- Ischemic stroke, resulting from occlusion of a brain artery is the most common type of stroke
with a prevalence of 15 million people and the leading cause of long-term disability worldwide.
Importantly, partial spontaneous recovery of lost neurological functions occurs mainly during the
first months after stroke onset, albeit to a limited extent. Recovery has been attributed to mechanisms
of compensation but also by activation of endogenous repair processes. The area surrounding the
infarct has been extensively studied and revealed functional and structural changes, however, the
exact mechanisms underlying functional recovery have not been elucidated. The focus of the present
... (More) - Ischemic stroke, resulting from occlusion of a brain artery is the most common type of stroke
with a prevalence of 15 million people and the leading cause of long-term disability worldwide.
Importantly, partial spontaneous recovery of lost neurological functions occurs mainly during the
first months after stroke onset, albeit to a limited extent. Recovery has been attributed to mechanisms
of compensation but also by activation of endogenous repair processes. The area surrounding the
infarct has been extensively studied and revealed functional and structural changes, however, the
exact mechanisms underlying functional recovery have not been elucidated. The focus of the present
study has been to investigate if levodopa/benserazide treatment, a common medication used as
symptomatic treatment in Parkinson’s disease, affects processes enhancing recovery after stroke.
Importantly levodopa/benserazide treatment also enhanced motor recovery and motor learning in
preliminary stroke trials.
In a reverse translational approach we have demonstrated an improved functional recovery by
levodopa/benserazide treatment in a rat stroke model. We identified astrocytes and immune cells
to respond to the treatment and to be involved in recovery enhancing effects. Among the processes
affected by dopamine signaling were increased levels of the astrocyte derived neurotrophic factor,
glial cell line-derived neurotrophic factor. In addition, we also demonstrated for the first time that
dopamine signaling modulates inflammatory processes in the postischemic brain and periphery
involving T-cells.
Overall this investigation presents novel data regarding the role of dopamine signaling in the
postischemic brain of relevance for recovery after stroke. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4195965
- author
- Kuric, Enida LU
- supervisor
- opponent
-
- Professor Planas, Anna Maria, Department of Brain Ischemia and Neurodegeneration, Institute for Biomedical Research, Barcelona, Spain
- organization
- publishing date
- 2014
- type
- Thesis
- publication status
- published
- subject
- in
- Lund University Faculty of Medicine Doctoral Dissertation Series
- volume
- 2014:4
- pages
- 138 pages
- publisher
- Laboratory for Experimental Brain Research
- defense location
- Segerfalksalen, BMC, Sölvegatan 17, Lund
- defense date
- 2014-01-17 09:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-87651-25-0
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Faculty of Medicine (000022000), Neurosurgery (013026000), Laboratory for Experimental Brain Research (013041000)
- id
- a7c7ac88-6d03-4878-a070-d795312d0ed4 (old id 4195965)
- date added to LUP
- 2016-04-01 14:07:03
- date last changed
- 2020-09-16 16:25:02
@phdthesis{a7c7ac88-6d03-4878-a070-d795312d0ed4,
abstract = {{Ischemic stroke, resulting from occlusion of a brain artery is the most common type of stroke<br/><br>
with a prevalence of 15 million people and the leading cause of long-term disability worldwide.<br/><br>
Importantly, partial spontaneous recovery of lost neurological functions occurs mainly during the<br/><br>
first months after stroke onset, albeit to a limited extent. Recovery has been attributed to mechanisms<br/><br>
of compensation but also by activation of endogenous repair processes. The area surrounding the<br/><br>
infarct has been extensively studied and revealed functional and structural changes, however, the<br/><br>
exact mechanisms underlying functional recovery have not been elucidated. The focus of the present<br/><br>
study has been to investigate if levodopa/benserazide treatment, a common medication used as<br/><br>
symptomatic treatment in Parkinson’s disease, affects processes enhancing recovery after stroke.<br/><br>
Importantly levodopa/benserazide treatment also enhanced motor recovery and motor learning in<br/><br>
preliminary stroke trials.<br/><br>
In a reverse translational approach we have demonstrated an improved functional recovery by<br/><br>
levodopa/benserazide treatment in a rat stroke model. We identified astrocytes and immune cells<br/><br>
to respond to the treatment and to be involved in recovery enhancing effects. Among the processes<br/><br>
affected by dopamine signaling were increased levels of the astrocyte derived neurotrophic factor,<br/><br>
glial cell line-derived neurotrophic factor. In addition, we also demonstrated for the first time that<br/><br>
dopamine signaling modulates inflammatory processes in the postischemic brain and periphery<br/><br>
involving T-cells.<br/><br>
Overall this investigation presents novel data regarding the role of dopamine signaling in the<br/><br>
postischemic brain of relevance for recovery after stroke.}},
author = {{Kuric, Enida}},
isbn = {{978-91-87651-25-0}},
issn = {{1652-8220}},
language = {{eng}},
publisher = {{Laboratory for Experimental Brain Research}},
school = {{Lund University}},
series = {{Lund University Faculty of Medicine Doctoral Dissertation Series}},
title = {{Effects of Dopamine Signaling on Recovery and Inflammation after Ischemic Stroke}},
url = {{https://lup.lub.lu.se/search/files/3793812/4195974.pdf}},
volume = {{2014:4}},
year = {{2014}},
}