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Acute effects of liver vein occlusion by stent-graft placed in transjugular intrahepatic portosystemic shunt channel: An experimental study

Keussen, Inger LU ; Bergqvist, Lennart LU ; Rissler, Pehr LU and Cwikiel, W (2006) In Cardiovascular and Interventional Radiology 29(1). p.120-123
Abstract
The purpose of this study was to evaluate the effects of hepatic vein occlusion by stent-graft used in transjugular intrahepatic portosystemic shunt (TIPS). The experiments were performed in six healthy pigs under general anesthesia. Following percutaneous transhepatic implantation of a port-a-cath in the right hepatic vein, TIPS was created with a stent-graft (Viatorr; W L Gore, Flagstaff, AZ, USA). The outflow from the hepatic vein, blocked by the stent-graft was documented by injection of contrast medium and repeated injections of 99Tc(m)-labeled human serum albumin through the port-a-cath. After 2 weeks, the outflow was re-evaluated, the pigs were sacrificed, and histopathologic examination of the liver was performed. Occlusion of the... (More)
The purpose of this study was to evaluate the effects of hepatic vein occlusion by stent-graft used in transjugular intrahepatic portosystemic shunt (TIPS). The experiments were performed in six healthy pigs under general anesthesia. Following percutaneous transhepatic implantation of a port-a-cath in the right hepatic vein, TIPS was created with a stent-graft (Viatorr; W L Gore, Flagstaff, AZ, USA). The outflow from the hepatic vein, blocked by the stent-graft was documented by injection of contrast medium and repeated injections of 99Tc(m)-labeled human serum albumin through the port-a-cath. After 2 weeks, the outflow was re-evaluated, the pigs were sacrificed, and histopathologic examination of the liver was performed. Occlusion of the hepatic vein by a stent-graft had a short and temporary effect on the outflow. Histopathological examination from the affected liver segment showed no divergent pattern. Stent-grafts used in TIPS block the outflow from the liver vein, but do not have a prolonged circulatory effect and do not affect the liver parenchyma. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
transjugular intrahepatic portosystemic shunt, portal hypertension, stent-graft, hepatic vein occlusion
in
Cardiovascular and Interventional Radiology
volume
29
issue
1
pages
120 - 123
publisher
Springer
external identifiers
  • wos:000234728900019
  • scopus:31144450019
  • pmid:16228855
ISSN
1432-086X
DOI
10.1007/s00270-004-0288-x
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Radiology Unit (013241410), Radiation Physics, Lund (013034000), Pathology, (Lund) (013030000), Division V (013230900)
id
0c121aac-369b-4476-8640-f54adf99c910 (old id 419934)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16228855&dopt=Abstract
date added to LUP
2016-04-01 11:49:42
date last changed
2021-06-23 02:01:15
@article{0c121aac-369b-4476-8640-f54adf99c910,
  abstract     = {The purpose of this study was to evaluate the effects of hepatic vein occlusion by stent-graft used in transjugular intrahepatic portosystemic shunt (TIPS). The experiments were performed in six healthy pigs under general anesthesia. Following percutaneous transhepatic implantation of a port-a-cath in the right hepatic vein, TIPS was created with a stent-graft (Viatorr; W L Gore, Flagstaff, AZ, USA). The outflow from the hepatic vein, blocked by the stent-graft was documented by injection of contrast medium and repeated injections of 99Tc(m)-labeled human serum albumin through the port-a-cath. After 2 weeks, the outflow was re-evaluated, the pigs were sacrificed, and histopathologic examination of the liver was performed. Occlusion of the hepatic vein by a stent-graft had a short and temporary effect on the outflow. Histopathological examination from the affected liver segment showed no divergent pattern. Stent-grafts used in TIPS block the outflow from the liver vein, but do not have a prolonged circulatory effect and do not affect the liver parenchyma.},
  author       = {Keussen, Inger and Bergqvist, Lennart and Rissler, Pehr and Cwikiel, W},
  issn         = {1432-086X},
  language     = {eng},
  number       = {1},
  pages        = {120--123},
  publisher    = {Springer},
  series       = {Cardiovascular and Interventional Radiology},
  title        = {Acute effects of liver vein occlusion by stent-graft placed in transjugular intrahepatic portosystemic shunt channel: An experimental study},
  url          = {https://lup.lub.lu.se/search/files/2659871/625011.pdf},
  doi          = {10.1007/s00270-004-0288-x},
  volume       = {29},
  year         = {2006},
}