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Neuropsychological functions predict 1-and 3-year outcome in first-episode psychosis

Carlsson, Rickard LU ; Nyman, H ; Ganse, G and Cullberg, J (2006) In Acta Psychiatrica Scandinavica 113(2). p.102-111
Abstract
Objective: To examine neuropsychological performance as a possible predictor of course and outcome in first-episode psychotic (FEP) patients. Method: A group of consecutive FEP patients (n = 120) tested with Wechsler Adult Intelligence Scales-Revised (WAIS-R) at baseline was compared with a healthy group (n = 30) matched for age, education and gender. Relationship between WAIS-R and both Brief Psychiatric Rating Scale and Global Assessment of Function (GAF) ratings were studied at baseline and at 1- and 3-year follow-ups. Results: The performance of FEP patients was significantly lower (P < 0.001) than that of healthy comparison subjects on all WAIS-R subtests except for Information and Comprehension. The WAIS-R scores of patients with... (More)
Objective: To examine neuropsychological performance as a possible predictor of course and outcome in first-episode psychotic (FEP) patients. Method: A group of consecutive FEP patients (n = 120) tested with Wechsler Adult Intelligence Scales-Revised (WAIS-R) at baseline was compared with a healthy group (n = 30) matched for age, education and gender. Relationship between WAIS-R and both Brief Psychiatric Rating Scale and Global Assessment of Function (GAF) ratings were studied at baseline and at 1- and 3-year follow-ups. Results: The performance of FEP patients was significantly lower (P < 0.001) than that of healthy comparison subjects on all WAIS-R subtests except for Information and Comprehension. The WAIS-R scores of patients with schizophrenia syndromes (DSM-IV) were lower than those of patients with non-schizophrenia syndromes on Block Design. Low WAIS-R Full-Scale IQ scores in FEP patients predicted the presence of negative symptoms at 1-year follow-up and of low GAF ratings at 3-year follow-up. Conclusion: Neurocognitive performance at admission appears to predict various aspects of functional outcome in FEP. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
outcome, first-episode, cognitive functions, neuropsychology, episode psychosis, schizophrenia
in
Acta Psychiatrica Scandinavica
volume
113
issue
2
pages
102 - 111
publisher
Wiley-Blackwell
external identifiers
  • wos:000234662900005
  • pmid:16423161
  • scopus:33644758588
  • pmid:16423161
ISSN
1600-0447
DOI
10.1111/j.1600-0447.2005.00661.x
language
English
LU publication?
yes
id
c5a49942-882d-4468-8708-7407c684958b (old id 420017)
date added to LUP
2016-04-01 17:08:17
date last changed
2021-09-22 01:19:51
@article{c5a49942-882d-4468-8708-7407c684958b,
  abstract     = {Objective: To examine neuropsychological performance as a possible predictor of course and outcome in first-episode psychotic (FEP) patients. Method: A group of consecutive FEP patients (n = 120) tested with Wechsler Adult Intelligence Scales-Revised (WAIS-R) at baseline was compared with a healthy group (n = 30) matched for age, education and gender. Relationship between WAIS-R and both Brief Psychiatric Rating Scale and Global Assessment of Function (GAF) ratings were studied at baseline and at 1- and 3-year follow-ups. Results: The performance of FEP patients was significantly lower (P &lt; 0.001) than that of healthy comparison subjects on all WAIS-R subtests except for Information and Comprehension. The WAIS-R scores of patients with schizophrenia syndromes (DSM-IV) were lower than those of patients with non-schizophrenia syndromes on Block Design. Low WAIS-R Full-Scale IQ scores in FEP patients predicted the presence of negative symptoms at 1-year follow-up and of low GAF ratings at 3-year follow-up. Conclusion: Neurocognitive performance at admission appears to predict various aspects of functional outcome in FEP.},
  author       = {Carlsson, Rickard and Nyman, H and Ganse, G and Cullberg, J},
  issn         = {1600-0447},
  language     = {eng},
  number       = {2},
  pages        = {102--111},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Psychiatrica Scandinavica},
  title        = {Neuropsychological functions predict 1-and 3-year outcome in first-episode psychosis},
  url          = {http://dx.doi.org/10.1111/j.1600-0447.2005.00661.x},
  doi          = {10.1111/j.1600-0447.2005.00661.x},
  volume       = {113},
  year         = {2006},
}