High Familial Risk of Atrial Fibrillation/Atrial Flutter in Multiplex Families: A Nationwide Family Study in Sweden
(2013) In Journal of the American Heart Association 2(1). p.003384-003384- Abstract
- Background-Although the heritability of atrial fibrillation/atrial flutter (AF/AFl) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of AF/AFl in multiplex families. Methods and Results-We examined the familial risk of AF/AFl in the entire Swedish population. We linked Multigeneration Register data on individuals aged 0 to 76 years with Hospital Discharge Register data for 1987-2008 and Outpatient Register data for 2001-2008 to compare AF/AFl risk among relatives of all 300 586 individuals with AF/AFl with that among relatives of unaffected individuals. We used conditional logistic regression to investigate differences in exposure between cases... (More)
- Background-Although the heritability of atrial fibrillation/atrial flutter (AF/AFl) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of AF/AFl in multiplex families. Methods and Results-We examined the familial risk of AF/AFl in the entire Swedish population. We linked Multigeneration Register data on individuals aged 0 to 76 years with Hospital Discharge Register data for 1987-2008 and Outpatient Register data for 2001-2008 to compare AF/AFl risk among relatives of all 300 586 individuals with AF/AFl with that among relatives of unaffected individuals. We used conditional logistic regression to investigate differences in exposure between cases and controls. Parents (odds ratio [OR] 1.95 [95% CI 1.89 to 2.00]) and siblings (OR=3.08 [3.00 to 3.16]) of cases had higher odds of AF/AFl than did parents and siblings of controls. AF/AFl ORs were increased in both sexes. For 2% of cases, both parents had AF/AFl, compared with only 0.7% of controls (OR= 3.60 [3.30 to 3.92]). Moreover, 3% of cases had >= 2 siblings with AF/AFl, compared with 1% of controls (OR= 5.72 [5.28 to 6.19]). In premature cases (diagnosed at age < 50 years), the ORs were 5.04 (4.36 to 5.82) and 8.51 (6.49 to 11.15) for AF/AFl in both parents and AF/AFl in >= 2 siblings, respectively. The overall spouse OR was 1.16 (1.13 to 1.19). Conclusions-Family history of AF/AFl increases the odds of AF/AFl in first-degree relatives. High familial risks were observed in multiplex families. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4212466
- author
- Zöller, Bengt LU ; Ohlsson, Henrik LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- atrial fibrillation, atrial flutter, family history, risk factors, genetics
- in
- Journal of the American Heart Association
- volume
- 2
- issue
- 1
- pages
- 003384 - 003384
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000326336800042
- scopus:84884175582
- pmid:23525409
- ISSN
- 2047-9980
- DOI
- 10.1161/JAHA.112.003384
- language
- English
- LU publication?
- yes
- id
- 7e987b48-62dc-4fc8-89cb-ada1fff5677e (old id 4212466)
- date added to LUP
- 2016-04-01 13:41:06
- date last changed
- 2022-04-14 02:26:58
@article{7e987b48-62dc-4fc8-89cb-ada1fff5677e, abstract = {{Background-Although the heritability of atrial fibrillation/atrial flutter (AF/AFl) has been determined, the familial risk in multiplex families is unclear. The main aim of this nationwide study was to determine the familial risk of AF/AFl in multiplex families. Methods and Results-We examined the familial risk of AF/AFl in the entire Swedish population. We linked Multigeneration Register data on individuals aged 0 to 76 years with Hospital Discharge Register data for 1987-2008 and Outpatient Register data for 2001-2008 to compare AF/AFl risk among relatives of all 300 586 individuals with AF/AFl with that among relatives of unaffected individuals. We used conditional logistic regression to investigate differences in exposure between cases and controls. Parents (odds ratio [OR] 1.95 [95% CI 1.89 to 2.00]) and siblings (OR=3.08 [3.00 to 3.16]) of cases had higher odds of AF/AFl than did parents and siblings of controls. AF/AFl ORs were increased in both sexes. For 2% of cases, both parents had AF/AFl, compared with only 0.7% of controls (OR= 3.60 [3.30 to 3.92]). Moreover, 3% of cases had >= 2 siblings with AF/AFl, compared with 1% of controls (OR= 5.72 [5.28 to 6.19]). In premature cases (diagnosed at age < 50 years), the ORs were 5.04 (4.36 to 5.82) and 8.51 (6.49 to 11.15) for AF/AFl in both parents and AF/AFl in >= 2 siblings, respectively. The overall spouse OR was 1.16 (1.13 to 1.19). Conclusions-Family history of AF/AFl increases the odds of AF/AFl in first-degree relatives. High familial risks were observed in multiplex families.}}, author = {{Zöller, Bengt and Ohlsson, Henrik and Sundquist, Jan and Sundquist, Kristina}}, issn = {{2047-9980}}, keywords = {{atrial fibrillation; atrial flutter; family history; risk factors; genetics}}, language = {{eng}}, number = {{1}}, pages = {{003384--003384}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of the American Heart Association}}, title = {{High Familial Risk of Atrial Fibrillation/Atrial Flutter in Multiplex Families: A Nationwide Family Study in Sweden}}, url = {{http://dx.doi.org/10.1161/JAHA.112.003384}}, doi = {{10.1161/JAHA.112.003384}}, volume = {{2}}, year = {{2013}}, }