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AN INTERNAL RADIATION DOSIMETRY COMPUTER PROGRAM, IDAC 2.0, FOR ESTIMATION OF PATIENT DOSES FROM RADIOPHARMACEUTICALS.

Andersson, Martin LU ; Johansson, L; Minarik, David LU ; Mattsson, Sören LU and Leide Svegborn, Sigrid LU (2014) In Radiation Protection Dosimetry 162(3). p.299-305
Abstract
The internal dosimetry computer program internal dose assessment by computer (IDAC) for calculations of absorbed doses to organs and tissues as well as effective doses to patients from examinations with radiopharmaceuticals has been developed. The new version, IDAC2.0, incorporates the International Commission on Radiation Protection (ICRP)/ICRU computational adult male and female voxel phantoms and decay data from the ICRP publication 107. Instead of only 25 source and target regions, calculation can now be made with 63 source regions to 73 target regions. The major advantage of having the new phantom is that the calculations of the effective doses can be made with the latest tissue weighting factors of ICRP publication 103. IDAC2.0 uses... (More)
The internal dosimetry computer program internal dose assessment by computer (IDAC) for calculations of absorbed doses to organs and tissues as well as effective doses to patients from examinations with radiopharmaceuticals has been developed. The new version, IDAC2.0, incorporates the International Commission on Radiation Protection (ICRP)/ICRU computational adult male and female voxel phantoms and decay data from the ICRP publication 107. Instead of only 25 source and target regions, calculation can now be made with 63 source regions to 73 target regions. The major advantage of having the new phantom is that the calculations of the effective doses can be made with the latest tissue weighting factors of ICRP publication 103. IDAC2.0 uses the ICRP human alimentary tract (HAT) model for orally administrated activity and for excretion through the gastrointestinal tract and effective doses have been recalculated for radiopharmaceuticals that are orally administered. The results of the program are consistent with published data using the same specific absorption fractions and also compared with published data from the same computational phantoms but with segmentation of organs leading to another set of specific absorption fractions. The effective dose is recalculated for all the 34 radiopharmaceuticals that are administered orally and has been published by the ICRP. Using the new HAT model, new tissue weighting factors and the new adult computational voxel phantoms lead to an average effective dose of half of its earlier estimated value. The reduction mainly depends on electron transport simulations to walled organs and the transition from the stylised phantom with unrealistic interorgan distances to more realistic voxel phantoms. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
162
issue
3
pages
299 - 305
publisher
Nuclear Technology Publishing
external identifiers
  • pmid:24353030
  • wos:000347733600015
  • scopus:84928671224
ISSN
1742-3406
DOI
10.1093/rpd/nct337
language
English
LU publication?
yes
id
2adefea6-5d94-4842-bbf0-aefc4a8952fb (old id 4223511)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24353030?dopt=Abstract
date added to LUP
2014-01-05 19:20:29
date last changed
2017-11-19 03:11:09
@article{2adefea6-5d94-4842-bbf0-aefc4a8952fb,
  abstract     = {The internal dosimetry computer program internal dose assessment by computer (IDAC) for calculations of absorbed doses to organs and tissues as well as effective doses to patients from examinations with radiopharmaceuticals has been developed. The new version, IDAC2.0, incorporates the International Commission on Radiation Protection (ICRP)/ICRU computational adult male and female voxel phantoms and decay data from the ICRP publication 107. Instead of only 25 source and target regions, calculation can now be made with 63 source regions to 73 target regions. The major advantage of having the new phantom is that the calculations of the effective doses can be made with the latest tissue weighting factors of ICRP publication 103. IDAC2.0 uses the ICRP human alimentary tract (HAT) model for orally administrated activity and for excretion through the gastrointestinal tract and effective doses have been recalculated for radiopharmaceuticals that are orally administered. The results of the program are consistent with published data using the same specific absorption fractions and also compared with published data from the same computational phantoms but with segmentation of organs leading to another set of specific absorption fractions. The effective dose is recalculated for all the 34 radiopharmaceuticals that are administered orally and has been published by the ICRP. Using the new HAT model, new tissue weighting factors and the new adult computational voxel phantoms lead to an average effective dose of half of its earlier estimated value. The reduction mainly depends on electron transport simulations to walled organs and the transition from the stylised phantom with unrealistic interorgan distances to more realistic voxel phantoms.},
  author       = {Andersson, Martin and Johansson, L and Minarik, David and Mattsson, Sören and Leide Svegborn, Sigrid},
  issn         = {1742-3406},
  language     = {eng},
  number       = {3},
  pages        = {299--305},
  publisher    = {Nuclear Technology Publishing},
  series       = {Radiation Protection Dosimetry},
  title        = {AN INTERNAL RADIATION DOSIMETRY COMPUTER PROGRAM, IDAC 2.0, FOR ESTIMATION OF PATIENT DOSES FROM RADIOPHARMACEUTICALS.},
  url          = {http://dx.doi.org/10.1093/rpd/nct337},
  volume       = {162},
  year         = {2014},
}