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Inflammatory plasma markers and risk for venous thromboembolism.

Sveinsdottir, Signy LU ; Svensson, Peter LU and Engström, Gunnar LU (2014) In Journal of Thrombosis and Thrombolysis 38(2). p.190-195
Abstract
Venous thromboembolism (VTE) and arterial thrombosis have been thought to result from two different mechanisms. Recent data indicate that the two diseases may share some common risk factors, such as the activity of inflammation on haemostasis. In this population-based study we explored whether raised levels of inflammation-sensitive plasma markers (ISPs) increase the risk for venous thromboembolism. Measurements of five ISPs (fibrinogen, haptoglobin, ceruloplasmin, α1-antitrypsin and orosomucoid) were performed in 6,068 subjects from "the Malmö Preventive Study". These apparently healthy men from the city of Malmö in Sweden, were included in the study between 1974 and 1982 and followed up until 2008. We calculated the hazard ratio (HR) for... (More)
Venous thromboembolism (VTE) and arterial thrombosis have been thought to result from two different mechanisms. Recent data indicate that the two diseases may share some common risk factors, such as the activity of inflammation on haemostasis. In this population-based study we explored whether raised levels of inflammation-sensitive plasma markers (ISPs) increase the risk for venous thromboembolism. Measurements of five ISPs (fibrinogen, haptoglobin, ceruloplasmin, α1-antitrypsin and orosomucoid) were performed in 6,068 subjects from "the Malmö Preventive Study". These apparently healthy men from the city of Malmö in Sweden, were included in the study between 1974 and 1982 and followed up until 2008. We calculated the hazard ratio (HR) for VTE in relation to the number of raised ISPs as well as individual ISPs in the fourth quartile. Mean follow-up time was 26.2 years. Out of the cohort (n = 6,068), 398 (6.6 %) had a venous thromboembolism during the follow-up. The number of raised ISPs was significantly associated with age, BMI and smoking. Age, BMI and diabetes mellitus type 2 were also significant risk factors for developing a VTE (HR = 1.05 with p < 0.01 and 95 % CI 1.01-1.08, HR = 1.10 with p < 0.001 and 95 % CI 1.06-1.14 and HR = 1.78 with p < 0.05 and 95 % CI 1.13-2.81, respectively). Incidence of venous thromboembolism was not significantly related to number of raised inflammatory proteins (p for trend = 0.37) or any of the individual ISPs. Age and BMI is significantly associated with the risk for developing VTE. Incidence of VTE was not associated with any of the inflammatory proteins. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Thrombosis and Thrombolysis
volume
38
issue
2
pages
190 - 195
publisher
Springer
external identifiers
  • pmid:24307292
  • wos:000338706400008
  • scopus:84904722879
ISSN
1573-742X
DOI
10.1007/s11239-013-1033-6
language
English
LU publication?
yes
id
4b1861df-9c8a-4b01-b1cc-e42ab875131f (old id 4225218)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24307292?dopt=Abstract
date added to LUP
2014-01-03 11:30:15
date last changed
2017-01-01 03:30:01
@article{4b1861df-9c8a-4b01-b1cc-e42ab875131f,
  abstract     = {Venous thromboembolism (VTE) and arterial thrombosis have been thought to result from two different mechanisms. Recent data indicate that the two diseases may share some common risk factors, such as the activity of inflammation on haemostasis. In this population-based study we explored whether raised levels of inflammation-sensitive plasma markers (ISPs) increase the risk for venous thromboembolism. Measurements of five ISPs (fibrinogen, haptoglobin, ceruloplasmin, α1-antitrypsin and orosomucoid) were performed in 6,068 subjects from "the Malmö Preventive Study". These apparently healthy men from the city of Malmö in Sweden, were included in the study between 1974 and 1982 and followed up until 2008. We calculated the hazard ratio (HR) for VTE in relation to the number of raised ISPs as well as individual ISPs in the fourth quartile. Mean follow-up time was 26.2 years. Out of the cohort (n = 6,068), 398 (6.6 %) had a venous thromboembolism during the follow-up. The number of raised ISPs was significantly associated with age, BMI and smoking. Age, BMI and diabetes mellitus type 2 were also significant risk factors for developing a VTE (HR = 1.05 with p &lt; 0.01 and 95 % CI 1.01-1.08, HR = 1.10 with p &lt; 0.001 and 95 % CI 1.06-1.14 and HR = 1.78 with p &lt; 0.05 and 95 % CI 1.13-2.81, respectively). Incidence of venous thromboembolism was not significantly related to number of raised inflammatory proteins (p for trend = 0.37) or any of the individual ISPs. Age and BMI is significantly associated with the risk for developing VTE. Incidence of VTE was not associated with any of the inflammatory proteins.},
  author       = {Sveinsdottir, Signy and Svensson, Peter and Engström, Gunnar},
  issn         = {1573-742X},
  language     = {eng},
  number       = {2},
  pages        = {190--195},
  publisher    = {Springer},
  series       = {Journal of Thrombosis and Thrombolysis},
  title        = {Inflammatory plasma markers and risk for venous thromboembolism.},
  url          = {http://dx.doi.org/10.1007/s11239-013-1033-6},
  volume       = {38},
  year         = {2014},
}